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Scopolamine (Scopolamine Hydrobromide) - Drug Interactions, Contraindications, Overdosage, etc



SCOPOLAMINE drug label information in our database does not contain a dedicated section on drug interactions. Please check subsections of WARNINGS AND PRECAUTIONS as well as other sources.


Serious systemic intoxication can occur even from topical ophthalmologic application, especially in children, since both local absorption and nasolacrimal drainage into the gut can deliver considerable amounts to the circulation.  In serious intoxication, hyperpyrexia, flushing, nausea, vomiting, drowsiness, disorientation, stupor, hallucinations, leukocytosis, nonallergenic rashes, circulatory or respiratory collapse, even death, in addition to all aforenamed effects, may occur.  Children, especially infants and children with mongolism, spastic paralysis or brain damage, are more sensitive than adults to the toxic effects.

If marked excitement is present and more specific treatment is not available, diazepam is most suitable for sedation and for control of convulsions.  Large doses should be avoided because the central depressant action may coincide with the depression occurring late in belladonna poisoning.  Phenothiazines should not be used because their antimuscuranic action is likely to intensify toxicity and may plunge the patient into coma.  Artificial respiration with oxygen may be necessary.  Ice bags and alcohol sponges help to reduce fever, especially in children.


Scopolamine hydrobromide is contraindicated in patients with narrow-angle glaucoma, since administration of the drug could raise the intraocular pressure to dangerous levels.  However, this will not happen for side-angle glaucoma patients.  Repeated administration of scopolamine to a patient with chronic lung disease is considered to be potentially hazardous.  Patients hypersensitive to belladonna or to barbiturates may be hypersensitive to scopolamine hydrobromide.

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