DOSAGE AND ADMINISTRATION
Adult
For obstetric amnesia or preoperative sedation, 0.32 to 0.65 mg (320 to 650 mcg).
For sedation or tranquilization, 0.6 mg (600 mcg) 3 or 4 times a day.
Subcutaneous, as an antiemetic, 0.6 to 1 mg.
Pediatric
Age 6 mo. to 3 yr., 0.1 to 0.15 mg (100 to 150 mcg). Age 3 to 6 yr., 0.2 to 0.3 mg (200 to 300 mcg).
Subcutaneous, as antiemetic, 0.006 mg (6 mcg) per kg.
Dosage Equivalents
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1 mg (1000 mcg)/mL
|
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1 mg
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(1000 mcg)
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1 mL
|
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0.8 mg
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(800 mcg)
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0.8 mL
|
|
0.6 mg
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(600 mcg)
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0.6 mL
|
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0.5 mg
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(500 mcg)
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0.5 mL
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0.4 mg
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(400 mcg)
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0.4 mL
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0.3 mg
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(300 mcg)
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0.3 mL
|
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0.2 mg
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(200 mcg)
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0.2 mL
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0.1 mg
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(100 mcg)
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0.1 mL
|
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0.4 mg (400 mcg)/mL
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0.4 mg
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(400 mcg)
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1 mL
|
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0.3 mg
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(300 mcg)
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0.75 mL
|
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0.25 mg
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(250 mcg)
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0.63 mL
|
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0.2 mg
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(200 mcg)
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0.50 mL
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0.15 mg
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(150 mcg)
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0.38 mL
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Belladonna alkaloids provide a therapeutic effect in about 1 or 2 hours with a duration of about 4 hours.
Geriatric and debilitated patients may respond to the usual doses with excitement, agitation, drowsiness or confusion; lower doses may be required in such patients.
Close supervision is recommended for infants, blondes, mongoloids and children with spastic paralysis or brain damage, since an increased responsiveness to belladonna alkaloids has been reported in these patients and dosage adjustments are often required.
Administration of belladonna alkaloids and barbiturates 30 to 60 minutes before meals is recommended to maximize absorption and, when issued for reducing stomach acid formation, to allow its effect to coincide better with antacid administration following the meal.
Parenteral drug products should be inspected visually for particulate matter prior to administration, whenever solution and container permit.
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