SCANDONEST® 3% PLAIN
(Mepivacaine hydrochloride injection, USP)
SCANDONEST® 2% L
(WITH LEVONORDEFRIN 1:20,000)
(Mepivacaine hydrochloride and Levonordefrin injection, USP)
Rx only
THESE SOLUTIONS ARE INTENDED FOR DENTAL USE ONLY.
Description
Mepivacaine hydrochloride, a tertiary amide used as a local anesthetic, is 1-methyl-2', 6'-pipecoloxylidide monohydrochloride with the following structural formula:
C15 H22 N2O. HCL M.W. 282.81
It is a white, crystalline, odorless powder soluble in water, but very resistant to both acid and alkaline hydrolysis.
Levonordefrin, a sympathomimetic amine used as a vasoconstrictor in local anesthetic solutions, is (-)-a-(1- Aminoethyl)- 3, 4-dihydroxybenzyl alcohol with the following structural formula:
C9 H13 NO3 M.W. 183.21
It is a white or buff-colored crystalline solid, freely soluble in aqueous solutions of mineral acids, but practically insoluble in water;
DENTAL CARTRIDGES MAY NOT BE AUTOCLAVED.
SCANDONEST 3% PLAIN (mepivacaine hydrochloride injection 3%) and SCANDONEST 2% L (mepivacaine hydrochloride 2% with levonordefrin 1:20,000 injection) are sterile solutions for injection.
Composition
| Cartridge |
|---|
| Each mL contains: | 2% | 3% |
|---|
| Mepivacaine hydrochloride | 20 mg | 30 mg |
| Levonordefrin | 0.05 mg | - |
| Sodium chloride | 4 mg | 6 mg |
| Potassium metabisulfite | 1.2 mg | |
| Edetate disodium | 0.25 mg | |
Sodium hydroxide q.s. ad pH
Hydrochloric acid | 0.5 mg | |
| Water for injections q.s. ad | 1 mL | 1 mL |
The pH of the 2% cartridge solution is adjusted between 3.3 and 5.5 with NaOH.
The pH of the 3% cartridge solution is adjusted between 4.5 and 6.8 with NaOH.
|
