Sanctura (Trospium Chloride) - Drug Interactions, Contraindications, Overdosage

DRUG-DRUG INTERACTIONS

No in vivo drug-drug interaction studies have been performed to assess the effect of concomitant medications on the pharmacokinetics of Sanctura or to assess the effect of Sanctura on the pharmacokinetics of other drugs. Sanctura is metabolized by esterases and excreted by the kidneys by a combination of tubular secretion and glomerular filtration. Based on in vitro data, no clinically relevant interactions with the metabolism of trospium are expected. However, drugs which are actively secreted may interact with trospium by competing for renal tubular secretion. (See PRECAUTIONS: Drug Interactions).

OVERDOSAGE

MANAGEMENT OF OVERDOSAGE

Overdosage with Sanctura may result in severe anticholinergic effects. Treatment should be provided according to symptoms and supportive. In the event of overdosage, ECG monitoring is recommended.

A 7-month-old baby experienced tachycardia and mydriasis after administration of a single dose of trospium 10 mg given by a sibling. The baby's weight was reported as 5 kg. Following admission into the hospital and about 1 hour after ingestion of the trospium, medicinal charcoal was administered for detoxification. While hospitalized, the baby experienced mydriasis and tachycardia up to 230 beats/minute. Therapeutic intervention was not deemed necessary. The baby was discharged as completely recovered the following day.

CONTRAINDICATIONS

Sanctura is contraindicated in patients with urinary retention, gastric retention, or uncontrolled narrow-angle glaucoma and in patients who are at risk for these conditions. Sanctura is also contraindicated in patients who have demonstrated hypersensitivity to the drug or its ingredients.