SANCTURA XR SUMMARY
SANCTURA XR is an extended-release formulation of trospium chloride, a quaternary ammonium compound. Trospium chloride is an antispasmodic, antimuscarinic agent.
SANCTURA® XR is indicated for the treatment of overactive bladder (OAB) with symptoms of urge urinary incontinence, urgency, and urinary frequency.
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NEWS HIGHLIGHTS
Published Studies Related to Sanctura XR (Trospium)
Once-daily trospium chloride 60 mg extended release in subjects with overactive bladder syndrome who use multiple concomitant medications: Post hoc analysis of pooled data from two randomized, placebo-controlled trials. [2011.02.01]
BACKGROUND: Overactive bladder syndrome (OAB) is associated with various co-morbidities; treatment of these frequently results in multiple medication use (MMU) and the potential for drug-drug interactions, which may lead to adverse events and altered efficacy... The data support the conclusion that trospium chloride XR is safe and effective in patients with OAB taking multiple concomitant medications.
Trospium chloride once-daily extended release is efficacious and tolerated in elderly subjects (aged >/= 75 years) with overactive bladder syndrome. [2011.02]
CONCLUSIONS: * Once-daily trospium chloride 60 mg ER demonstrated efficacy vs placebo and was tolerated in subjects aged >/= 75 years with OAB. * For subjects who continued into the open-label treatment period, efficacy and tolerability were observed for up to 1 year. (c) 2010 THE AUTHORS. JOURNAL COMPILATION (c) 2010 BJU INTERNATIONAL.
Safety and efficacy of once-daily trospium chloride extended-release in male patients with overactive bladder. [2011.01]
OBJECTIVES: This study used pooled data from 2 large, phase III, double-blind, randomized, placebo-controlled studies for a subgroup analysis of the safety and efficacy of trospium chloride extended-release (XR) in men with overactive bladder (OAB)... CONCLUSIONS: Trospium XR is safe and effective in men with OAB. The risk of urinary retention is low and may be further decreased by careful patient selection. Copyright A(c) 2011 Elsevier Inc. All rights reserved.
Once-daily trospium chloride 60 mg extended-release provides effective, long-term
relief of overactive bladder syndrome symptoms. [2011]
tolerability of trospium XR... CONCLUSIONS: Long-term treatment of OAB with once-daily trospium 60 mg XR is
Comparison of intravaginal electrical stimulation and trospium hydrochloride in women with overactive bladder syndrome: a randomized controlled study. [2010.04]
OBJECTIVE: To compare the effects of trospium hydrochloride and electrical stimulation on urodynamic parameters, bladder diary, quality of life and psychological symptoms in female patients with overactive bladder syndrome... CONCLUSION: No difference was detected between trospium hydrochloride and intravaginal electrical stimulation in the treatment of female overactive bladder syndrome. Discontinuation of both treatments caused deterioration in most of the objective and subjective symptoms of overactive bladder syndrome.
Clinical Trials Related to Sanctura XR (Trospium)
Efficacy of Sanctura XR (Trospium Chloride) for Reducing Overactive Bladder Symptoms in Female Subjects Refractory to Detrol LA (Tolterodine Tartrate Extended Release) Daily [Recruiting]
This study will investigate the safety and efficacy of Sanctura XR (trospium chloride) daily
in reducing urgency, urinary frequency and urinary urge incontinence in female patients with
the incontinence refractory to Detrol LA (tolterodine tartrate extended release) 4 mg
therapy.
Safety and Tolerability of Trospium Chloride and Metformin Hydrochloride in Healthy Subjects [Not yet recruiting]
The purpose of this study is to investigate the safety and tolerability of trospium chloride
(Sanctura XRâ„¢) and metformin hydrochloride (Glucophage) when co-administered.
Trospium Chloride XR in Obese Female Patients With Overactive Bladder [Recruiting]
This study evaluates the effectiveness of trospium XR in obese female patients with
overactive bladder. The study will have a 2-week placebo run-in followed by randomization
to trospium XR or placebo. The study will assess the change from baseline in urinary
frequency, urgency, and incontinence for trospium XR versus a placebo-pill. The study will
be of 14 weeks duration.
Sanctura Muscarinic Receptor Antagonist Resists Transport (SMART-II) Trial [Recruiting]
This study will evaluate the cerebrospinal fluid levels of trospium chloride and oxybutynin
on memory performance in patients with overactive bladder and age associated memory
impairment.
Sanctura Muscarinic Receptor Antagonist Resists Transport (SMART) Trial [Not yet recruiting]
This study evaluates the penetration through the blood-brain-barrier of trospium chloride at
plasma steady state (Day 10) in elderly subjects with overactive bladder symptoms. Trospium
levels in cerebrospinal fluid (CSF) and peak and trough plasma levels will be measured.
Baseline and day 10 post-dose neurocognitive testing will be compared using a reliable
change index to assess if any study subject shows evidence of a clinically and statistically
significant change in memory.
Reports of Suspected Sanctura XR (Trospium) Side Effects
Constipation (13),
DRY Mouth (9),
Drug Ineffective (8),
Urinary Retention (5),
Vomiting (5),
Headache (4),
Nausea (4),
Arthralgia (4),
Diarrhoea (4),
Flatulence (3), more >>
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PATIENT REVIEWS / RATINGS / COMMENTSBased on a total of 1 ratings/reviews, Sanctura XR has an overall score of 10. The effectiveness score is 8 and the side effect score is 8. The scores are on ten point scale: 10 - best, 1 - worst.
| | Sanctura XR review by 60 year old female patient | | | Rating |
| Overall rating: | |  |
| Effectiveness: | | Considerably Effective |
| Side effects: | | Mild Side Effects | | |
Treatment Info |
| Condition / reason: | | overactive bladder |
| Dosage & duration: | | 60mg taken 1 a day for the period of taken it for 4 months |
| Other conditions: | | rapid pulse |
| Other drugs taken: | | toperol | | |
Reported Results |
| Benefits: | | With OAB there was the urge to urinate frequently which felt like a constant mild bladder infection. There was some relief after a couple of days on this drug. However, some days I felt as poorly as I did without them. But after approximately 8 weeks almost all of the discomfort was gone. I feel pretty normal. One key to making this work is to deliberately not urinate too often. I have noticed that now I sometimes need to remind myself to go. I probably feel the urge less than I did before I had this problem. |
| Side effects: | | Dry mouth if I fast from food. If I eat normally this does not happen. Other than that, no side effects. |
| Comments: | | Take one capsule in the morning before eating breakfast - on an empty stomache. |
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Page last updated: 2013-02-10
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