NEWS HIGHLIGHTSMedia Articles Related to Roxicodone (Oxycodone)
Oxycodone May Reduce Shingles Pain
Source: MedicineNet Chickenpox (Varicella) Specialty [2009.04.13]
Title: Oxycodone May Reduce Shingles Pain
Category: Health News
Created: 4/11/2009 2:00:00 AM
Last Editorial Review: 4/13/2009
Yoga May Be Effective For Chronic Low Back Pain In Minority Populations
Source: Health News from Medical News Today [2009.11.05]
Researchers from Boston University School of Medicine (BUSM) and Boston Medical Center found that yoga may be more effective than standard treatment for reducing chronic low back pain in minority populations. This study appears in the November issue of Alternative Therapies in Health and Medicine.
Radiation Therapy Technique Successfully Treats Pain In Patients With Advanced Cancer
Source: Cancer / Oncology News From Medical News Today [2009.11.05]
Stereotactic radiosurgery (SRS), a radiation therapy procedure pioneered at the University of Pittsburgh Cancer Institute (UPCI) that precisely delivers a large dose of radiation to tumors, effectively controls pain in patients with cancer that has spread to the spine, according to researchers from UPCI. The results of the research were presented this week during the American Society for Radiation Oncology (ASTRO) annual meeting in Chicago, being held November 1 - 5, 2009.
Common Pain Relievers May Dilute Power Of Flu Shots
Source: Biology / Biochemistry News From Medical News Today [2009.11.04]
With flu vaccination season in full swing, research from the University of Rochester Medical Center cautions that use of many common pain killers -- Advil, Tylenol, aspirin -- at the time of injection may blunt the effect of the shot and have a negative effect on the immune system. Richard P. Phipps, Ph.D.
Cancer, Pain Relief And Immunity Research Supported By ARC
Source: Breast Cancer News From Medical News Today [2009.11.04]
Research at the Walter and Eliza Hall Institute into the genes involved in breast cancer development, new drugs for chronic pain, and the proteins involved in inflammatory diseases has received funding in this year's round of Australian Research Council (ARC) Discovery Project grants. Seven projects proposed by institute researchers have received ARC support.
Published Studies Related to Roxicodone (Oxycodone)
Dexamethasone decreases oxycodone consumption following osteotomy of the first metatarsal bone: a randomized controlled trial in day surgery. [2009.10.10]
Background: Dexamethasone may improve multimodal pain management following painful orthopedic day surgery procedures, and decrease the need for post-operative opioids. We hypothesized that dexamethasone would reduce the need for oxycodone after surgical correction of hallux valgus... Conclusion: Oral dexamethasone combined with paracetamol significantly reduced total oxycodone consumption following surgical correction of hallux valgus.
A comparison of intravenous oxycodone and intravenous morphine in patient-controlled postoperative analgesia after laparoscopic hysterectomy. [2009.10]
INTRODUCTION: In this study, we investigated the dose requirements, pain relief, and side effects of oxycodone versus morphine after surgery with visceral pain... CONCLUSIONS: Oxycodone was more potent than morphine for visceral pain relief but not for sedation.
Analgesic efficacy of peripheral kappa-opioid receptor agonist CR665 compared to oxycodone in a multi-modal, multi-tissue experimental human pain model: selective effect on visceral pain. [2009.09]
BACKGROUND: Peripherally selective opioids may be beneficial in visceral pain management due to absence of centrally mediated side effects. The objectives of this study were: (1) to assess the effects of a peripherally selective tetrapeptide kappa-opioid receptor agonist, CR665, on experimental pain from multi-modal stimulation of skin, muscle, and viscera, and (2) contrast these effects with those of oxycodone (centrally acting opioid)... CONCLUSION: CR665 had a selective effect on visceral pain. Oxycodone exhibited a generalized effect, elevating thresholds for cutaneous, deep somatic, and visceral pain stimulation.
Relationship between rate of infusion and reinforcing strength of oxycodone in humans. [2009.07]
The rate of drug delivery to the central nervous system is believed to be an important predictor of the reinforcing strength of a drug. However, only a few studies have directly examined the relationship between drug-taking behavior and rate of drug administration... Specifically, these "abuse-deterrent formulations" could prevent patients from tampering with their medications to enhance their euphoric and reinforcing effects.
Rifampin greatly reduces the plasma concentrations of intravenous and oral oxycodone. [2009.06]
BACKGROUND: Oxycodone is a mu-opioid receptor agonist that is metabolized mainly in the liver by cytochrome P450 3A and 2D6 enzymes. Rifampin is a strong inducer of several drug-metabolizing enzymes. The authors studied the interaction of rifampin with oxycodone. Their hypothesis was that rifampin enhances the CYP3A-mediated metabolism of oxycodone and attenuates its pharmacologic effect... CONCLUSIONS: Induction of cytochrome P450 3A by rifampin reduced the area under the oxycodone concentration-time curve of intravenous and oral oxycodone. The pharmacologic effects of oxycodone were modestly attenuated. To maintain adequate analgesia, dose adjustment of oxycodone may be necessary, when used concomitantly with rifampin.
Clinical Trials Related to Roxicodone (Oxycodone)
Oxycodone-Naloxone Prolonged Release Tablets in Relieving Opioid-Related Constipation [Active, not recruiting]
Oxycodone-Naloxone in Relieving Opioid-Related Constipation [Active, not recruiting]
The primary objective of this study is to demonstrate that subjects with moderate to severe
non-malignant pain taking oxycodone/naloxone prolonged release tablets have improvement in
symptoms of constipation compared to subjects taking oxycodone prolonged release tablets
alone.
Morphine vs. Oxycodone for Postoperative Pain Management [Recruiting]
The purpose of this study is to determine whether oxycodone provides better analgesia
compared to morphine after laparoscopic hysterectomy or myomectomy.
OXY-1: The Pharmacogenetics of Oxycodone Analgesia in Postoperative Pain [Completed]
Patients undergoing surgery (thyroidectomy and hysterectomy) will postoperatively receive
oxycodone intravenously (IV) as pain management with morphine as an escape medicine, if there
is insufficient pain relief with oxycodone. Patients' pain and side effects will be
registered and after 24 hours they will answer a questionnaire. All included patients will be
genotyped accordingly to CYP2D6 and relevant single nucleotide polymorphisms (SNPs), and
measures of plasma levels of oxycodone will be performed.
Study of the Abuse Liability of Oxycodone HCl/Niacin in Subjects With a History of Opioid Abuse [Recruiting]
The purpose of this study is: (1) to assess the effect of oxycodone HCl on niacin-induced
dysphoric effects when oxycodone HCl is administered in combination with niacin in subjects
with a history of opioid abuse; (2) to assess the abuse liability of 4 times the usual
recommended dose of Acurox (oxycodone HCl 40 mg plus niacin 240 mg) versus oxycodone HCL 40
mg alone in subjects with a history of opioid abuse.
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