ROBAXIN SUMMARY
ROBAXIN Injectable (methocarbamol injection, USP)
Rx only
ROBAXIN (methocarbamol injection, USP) Injectable, a carbamate derivative of guaifenesin, is a central nervous system (CNS) depressant with sedative and musculoskeletal relaxant properties. It is a sterile, pyrogen-free solution intended for intramuscular or intravenous administration. Each mL contains: methocarbamol, USP 100 mg, polyethylene glycol 300, NF 0.5 mL, Water for Injection, USP q. s. The pH is adjusted, when necessary, with hydrochloric acid and/or sodium hydroxide.
The injectable form of methocarbamol is indicated as an adjunct to rest, physical therapy, and other measures for the relief of discomfort associated with acute, painful musculoskeletal conditions. The mode of action of this drug has not been clearly identified, but may be related to its sedative properties. Methocarbamol does not directly relax tense skeletal muscles in man.
|
NEWS HIGHLIGHTS
Published Studies Related to Robaxin (Methocarbamol)
Bioequivalence study with two different oral formulations of methocarbamol in healthy subjects. A mono-centre, comparative, randomized, open-label, single-dose, 2-way crossover study. [2009]
CONCLUSION: In this study bioequivalence could be demonstrated with respect to rate and extent of methocarbamol exposure.
Subjective and behavioral effects of diphenhydramine, lorazepam and methocarbamol: evaluation of abuse liability. [1992.08]
The effects of orally administered placebo, diphenhydramine, lorazepam, methocarbamol and placebo were studied in volunteers with histories of recreational substance abuse including sedative/hypnotics. Placebo, diphenhydramine (100, 200 and 400 mg), lorazepam (1 and 4 mg) and methocarbamol (2.25 and 9 g) were tested in a randomized, double-blind crossover study using 14 subjects...
Antagonist effects of nalbuphine in opioid-dependent human volunteers. [1989.03]
The subjective, physiological and behavioral effects of nalbuphine, an opioid mixed agonist/antagonist analgesic, naloxone and hydromorphone were studied on adult, male, methadone-dependent volunteers living on a clinical research ward. The purpose was to assess nalbuphine's agonist properties vs.The withdrawal syndrome precipitated by nalbuphine was indistinguishable from that produced by naloxone.
Does methocarbamol affect fatigue markers in the low-back electromyogram? [1998.12]
Many low-back patients undergo electromyography (EMG)-based evaluations of muscle performance but present to the clinic after being prescribed muscle relaxants. The question that needed to be addressed was, do centrally acting muscle relaxants (methocarbamol; Robaxin) affect the EMG spectral indices of muscle fatigue that are often used to assess muscle performance...
Pain reduction in breast augmentation using methocarbamol. [1997.01]
Submuscular placement of breast implants produces significant postoperative pain and discomfort... Significant pain relief was achieved.
Clinical Trials Related to Robaxin (Methocarbamol)
A Pilot Study of Recombinant Human Relaxin (rhRlx) in Compensated Congestive Heart Failure [Completed]
This trial is a single center, open-label, dose-finding study of recombinant human relaxin
(rhRlx) given intravenously (IV) to patients with stable, compensated CHF.
Recombinant Human Relaxin for the Treatment of Decompensated CHF [Active, not recruiting]
Two doses of relaxin will be compared to placebo for the treatment of patients with
decompensated CHF
Efficacy and Safety of Relaxin for the Treatment of Acute Heart Failure [Recruiting]
Different doses of relaxin will be compared to placebo to determine efficacy and safety for
the treatment of patients hospitalized with acute heart failure
Evaluation of the Safety of Relaxin in Preeclampsia [Recruiting]
The purpose of this study is to determine whether different doses of recombinant human
relaxin is safe when given to women with severe preeclampsia
Recombinant Human Relaxin (rhRlx) in Pregnant Women Scheduled for Induction of Labor [Completed]
The purpose of this study is to assess the safety and efficacy of rhRlx for cervical
ripening, when compared to a placebo.
|
|
|
|
Page last updated: 2009-10-20
|
