NEWS HIGHLIGHTSMedia Articles Related to Rituxan (Rituximab)
Genentech And Biogen Idec Receive A Complete Response From The FDA For Rituxan For Chronic Lymphocytic Leukemia
Source: Health News from Medical News Today [2009.11.19]
Genentech, Inc., a wholly-owned member of the Roche Group (SIX: RO, ROG; OTCQX: RHHBY), and Biogen Idec (Nasdaq: BIIB) announced today that the U.S.
Third PML Case Reported with Rituximab
Source: MedPage Today Rheumatology [2009.10.24]
A case of progressive multifocal leukoencephalopathy has been reported in a rheumatoid arthritis patient taking rituximab (Rituxan) who had not previously received anti-tumor necrosis factor therapy, according to the drug's manufacturer.
Researchers Find New Way To Attack Inflammation In Graves' Eye Disease
Source: Eye Health / Blindness News From Medical News Today [2009.11.07]
A small group of patients with severe Graves' eye disease experienced rapid improvement of their symptoms and improved vision following treatment with the drug rituximab. Inflammation around their eyes and damage to the optic nerve were significantly reduced. The same patients had not previously responded to steroids, a common treatment for Graves' eye disease. Raymond S. Douglas, M.D., Ph.D.
Pivotal Data Published In The Journal Cancer Demonstrate That TREANDA Induced Durable Responses In Relapsed Indolent Non-Hodgkin's Lymphoma
Source: Lymphoma / Leukemia / Myeloma News From Medical News Today [2009.11.06]
Cephalon, Inc. (Nasdaq: CEPH) announced the journal Cancer has published a pivotal study demonstrating that TREANDA® (bendamustine HCl) for Injection induced durable responses in patients with indolent B-cell non-Hodgkin's lymphoma (NHL) whose disease had progressed during or within six months of treatment with rituximab.
New Data On Bendamustine Offers Hope To Non-Hodgkin's Lymphoma Patients Resistant To Standard Therapy
Source: Lymphoma / Leukemia / Myeloma News From Medical News Today [2009.11.06]
New data published today in the journal, Cancer, reveals that three quarters (75%) of patients with indolent B-cell non-Hodgkin's lymphoma (iNHL), responded to treatment with Bendamustine following a single-arm, multicentre study. Significantly, all patients participating in the study had become resistant or were unresponsive to rituximab (the standard treatment for the disease) when used either as a single agent or in combination with other therapies. Professor Brad S.
Published Studies Related to Rituxan (Rituximab)
Is combination rituximab with cyclophosphamide better than rituximab alone in the treatment of lupus nephritis? [2009.08]
OBJECTIVE: To assess if combination rituximab and cyclophosphamide is more effective than rituximab monotherapy as an induction therapy for proliferative lupus nephritis... CONCLUSIONS: Rituximab monotherapy appears to be effective as induction therapy in lupus nephritis. The addition of cyclophosphamide offers no additional improvement in clinical, laboratory and renal histological assessment or the duration of B-cell depletion at 48 weeks. Large-scale studies with longer duration are needed to confirm these findings.
Placebo-controlled phase III trial of patient-specific immunotherapy with mitumprotimut-T and granulocyte-macrophage colony-stimulating factor after rituximab in patients with follicular lymphoma. [2009.06.20]
PURPOSE: To evaluate patient-specific immunotherapy with mitumprotimut-T (idiotype keyhole limpet hemocyanin [Id-KLH]) and granulocyte-macrophage colony-stimulating factor (GM-CSF) in CD20(+) follicular lymphoma... CONCLUSION: TTP was shorter with mitumprotimut-T/GM-CSF compared with placebo/GM-CSF. This difference was possibly due to the imbalance in FLIPI scores.
A randomized, doubleblind, placebo-controlled, study of single-dose rituximab as induction in renal transplantation. [2009.05.15]
CONCLUSION: We performed a placebo-controlled study of rituximab induction in renal transplantation. There was a tendency toward fewer and milder rejections during the first 6 months in the rituximab group. Although induction with one dose of rituximab induced a complete depletion B cells, there was no increase in the incidence of infectious complications or leukopenia and it seems safe, therefore, to conduct further studies on the use of rituximab in transplantation.
Maintenance rituximab after cyclophosphamide, vincristine, and prednisone prolongs progression-free survival in advanced indolent lymphoma: results of the randomized phase III ECOG1496 Study. [2009.04.01]
PURPOSE: To determine if maintenance rituximab (MR) after standard chemotherapy improves progression-free survival (PFS) in advanced-stage indolent lymphoma... CONCLUSION: The E1496 study provides the first phase III data in untreated indolent lymphoma that MR after chemotherapy significantly prolongs PFS.
Placebo-controlled trial of rituximab in IgM anti-myelin-associated glycoprotein antibody demyelinating neuropathy. [2009.03]
OBJECTIVE: Report a double-blind, placebo-controlled study of rituximab in patients with anti-MAG demyelinating polyneuropathy (A-MAG-DP)... INTERPRETATION: Rituximab is the first drug that improves some patients with A-MAG-DP in a controlled study. The benefit may be exerted by reducing the putative pathogenic antibodies or by inducing immunoregulatory T cells. The results warrant confirmation with a larger trial.
Clinical Trials Related to Rituxan (Rituximab)
Fludarabine, Mitoxantrone, and Dexamethasone (FND) Plus Rituximab for Lymphoma Patients [Active, not recruiting]
Primary Objectives:
1. To compare molecular response rates with the FND regimen followed by rituximab (chimeric
anti-CD20 antibody) and interferon versus FND plus rituximab concurrently, followed by
interferon, for patients with stage IV indolent lymphoma.
2. To compare the toxicity of these two regimens, including their effects on B- and T-cell
subsets, immunoglobulins, and patterns of infections.
3. To compare failure-free and overall survival rates with these two regimens.
4. To identify and treat with a separate strategy those follicular lymphoma patients
without bcl-2 mbr or mcr gene rearrangement ("germline" patients) because of their
adverse outcome with FND alone in our prior experience.
Study of Dynavax's 1018 ISS, Following Rituxan in Patients With B-Cell Follicular Lymphoma [Active, not recruiting]
The main purpose of this study is to determine the effects (good and bad) and the safety of
Dynavax's immunostimulatory phosphorothiolate oligodeoxyribonucleotide (1018 ISS) given in
combination with Rituxan on patients with B-cell follicular non-Hodgkin's lymphoma. This
research is being done because recurrent follicular non-Hodgkin's lymphoma is not curable
with standard chemotherapy or antibody treatments. 1018 ISS is an experimental compound that
consists of short pieces of DNA that stimulate the immune system. It is hoped that 1018 ISS
may improve the ability of Rituxan to kill cancer cells.
Treatment of Relapsed Low-Grade or Follicular Lymphoma With Rituximab (Also Known as Rituxan, IDEC-C2B8, IDEC-102) [Completed]
Rituximab is an antibody made in a laboratory. It binds to lymphoma cells and kills them.
Treatment of recurrent B-cell lymphoma with rituximab may delay or prevent relapses. A total
of 166 patients with recurrent B-cell lymphoma were given intravenous rituximab once a week
for 4 weeks. The patients' tumors were measured before and after treatment. Ten patients
had a complete response and 70 patients had a partial response to rituximab. The median
duration of response was 11. 2 months.
Rituximab (Rituxan) for the Prevention of EBV-LPD Epstein Barr Virus (EBV) Lymphoproliferative Disorder Post T Cell Depleted Unrelated and HLA Mis-Matched Related HSCT [Active, not recruiting]
The purpose of this study is to determine if we can prevent Epstein Barr Virus lymphomas by
the monthly administration of an (antibody) protein against B lymphocytes called Rituximab.
Although this medicine has been approved by the Food and Drug Administration to treat
patients with other types of lymphomas, and has been used to treat a small number of patients
with EBV lymphomas and other types of B-cell leukemias, it has not been approved to try and
prevent EBV-lymphomas. Use of Rituximab to try to prevent EBV-lymphomas is therefore
experimental.
Safety Study of Rituximab (RituxanŽ) in Chronic Urticaria [Suspended]
This study is being done to find out if a drug called Rituxan (Rituximab) is safe and
effective in treating people with chronic urticaria (hives) with persistent symptoms in spite
of taking antihistamines.
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