Media Articles Related to Rituxan (Rituximab)
Rituxan Offers Little Help for Sjogren's
Source: MedPage Today Rheumatology [2014.02.18]
(MedPage Today) -- Treatment for primary Sjogren's syndrome with the B-cell depleting antibody rituximab (Rituxan) failed to provide statistically significant improvements, despite the increasing evidence for B cells in the pathogenesis of this disorder, French researchers reported.
Patients with frequently relapsing kidney disease benefit from immune drug
Source: Arthritis / Rheumatology News From Medical News Today [2014.02.03]
In patients with a frequently-relapsing form of kidney disease, relapses decreased approximately five-fold for at least one year after patients took a single dose of rituximab, an antibody that targets the immune system and is often used to treat immune disorders such as lymphoma and arthritis.
Source: MedicineNet Biological Therapy Specialty [2011.09.08]
Title: Non-Hodgkin's Lymphoma
Category: Diseases and Conditions
Created: 12/31/1997 12:00:00 AM
Last Editorial Review: 9/8/2011 12:00:00 AM
Scientists explore promising new option for first line of attack in lymphoma
Source: Lymphoma / Leukemia / Myeloma News From Medical News Today [2014.02.26]
A study led by Manchester scientists has shown promising results for a new treatment approach in follicular lymphoma.Follicular lymphoma is a type of non-Hodgkin's lymphoma, a blood cancer, that usually develops slowly. The majority of patients are diagnosed when their disease is at an advanced stage.
Published Studies Related to Rituxan (Rituximab)
Treatment of antineutrophil cytoplasmic antibody-associated vasculitis with rituximab. [2012.01]
PURPOSE OF REVIEW: To review the present knowledge about the use of rituximab (RTX) in patients with granulomatosis with polyangiitis (Wegener's; GPA), microscopic polyangiitis (MPA), and eosinophilic granulomatosis with polyangiitis (Churg-Strauss; EGPA), also collectively referred to as antineutrophil cytoplasmic antibody-associated vasculitis...
Use of intravenous immunoglobulin to treat chronic bilateral otomastoiditis in
the setting of rituximab induced hypogammaglobulinemia. 
The temporal bone may be affected by a variety of systemic pathology because the
disease nature, location, and extent determine the symptoms... Here, we describe the first presentation, diagnostic workup, and treatment with
intravenous immunoglobulin of chronic bilateral otomastoiditis in the setting of
Efficacy and safety of rituximab in patients with active proliferative lupus
nephritis: the Lupus Nephritis Assessment with Rituximab study. 
treated concomitantly with mycophenolate mofetil (MMF) and corticosteroids... CONCLUSION: Although rituximab therapy led to more responders and greater
A randomized, controlled, trial of rituximab for treatment of severe cryoglobulinemic vasculitis. [2011.12.06]
OBJECTIVE: A prospective, long-term randomized controlled trial was designed to support the use of rituximab (RTX) for severe mixed cryoglobulinemia or cryoglobulinemic vasculitis (CV)... CONCLUSION: RTX monotherapy represents a very good option for severe CV and may be maintained in the long term in most patients. Copyright (c) 2011 by the American College of Rheumatology.
A randomized controlled trial of rituximab following failure of antiviral therapy for hepatitis C-associated cryoglobulinemic vasculitis. [2011.12.06]
OBJECTIVES: To report on the results of a randomized controlled trial of rituximab in hepatitis C virus (HCV)-associated mixed cryoglobulinemic vasculitis... CONCLUSIONS: Therapy with rituximab was well tolerated and effective treatment for patients with HCV-associated cryoglobulinemic vasculitis in whom antiviral therapy fails to induce remission. Copyright (c) 2011 by the American College of Rheumatology.
Clinical Trials Related to Rituxan (Rituximab)
Fludarabine, Mitoxantrone, and Dexamethasone (FND) Plus Rituximab for Lymphoma Patients [Active, not recruiting]
1. To compare molecular response rates with the FND regimen followed by rituximab (chimeric
anti-CD20 antibody) and interferon versus FND plus rituximab concurrently, followed by
interferon, for patients with stage IV indolent lymphoma.
2. To compare the toxicity of these two regimens, including their effects on B- and T-cell
subsets, immunoglobulins, and patterns of infections.
3. To compare failure-free and overall survival rates with these two regimens.
4. To identify and treat with a separate strategy those follicular lymphoma patients
without bcl-2 mbr or mcr gene rearrangement ("germline" patients) because of their
adverse outcome with FND alone in our prior experience.
Study of Dynavax's 1018 ISS, Following Rituxan in Patients With B-Cell Follicular Lymphoma [Active, not recruiting]
The main purpose of this study is to determine the effects (good and bad) and the safety of
Dynavax's immunostimulatory phosphorothiolate oligodeoxyribonucleotide (1018 ISS) given in
combination with Rituxan on patients with B-cell follicular non-Hodgkin's lymphoma. This
research is being done because recurrent follicular non-Hodgkin's lymphoma is not curable
with standard chemotherapy or antibody treatments. 1018 ISS is an experimental compound that
consists of short pieces of DNA that stimulate the immune system. It is hoped that 1018 ISS
may improve the ability of Rituxan to kill cancer cells.
Treatment of Relapsed Low-Grade or Follicular Lymphoma With Rituximab (Also Known as Rituxan, IDEC-C2B8, IDEC-102) [Completed]
Rituximab is an antibody made in a laboratory. It binds to lymphoma cells and kills them.
Treatment of recurrent B-cell lymphoma with rituximab may delay or prevent relapses. A total
of 166 patients with recurrent B-cell lymphoma were given intravenous rituximab once a week
for 4 weeks. The patients' tumors were measured before and after treatment. Ten patients
had a complete response and 70 patients had a partial response to rituximab. The median
duration of response was 11. 2 months.
Rituximab (Rituxan) for the Prevention of EBV-LPD Epstein Barr Virus (EBV) Lymphoproliferative Disorder Post T Cell Depleted Unrelated and HLA Mis-Matched Related HSCT [Active, not recruiting]
The purpose of this study is to determine if we can prevent Epstein Barr Virus lymphomas by
the monthly administration of an (antibody) protein against B lymphocytes called Rituximab.
Although this medicine has been approved by the Food and Drug Administration to treat
patients with other types of lymphomas, and has been used to treat a small number of patients
with EBV lymphomas and other types of B-cell leukemias, it has not been approved to try and
prevent EBV-lymphomas. Use of Rituximab to try to prevent EBV-lymphomas is therefore
Safety Study of Rituximab (RituxanŽ) in Chronic Urticaria [Suspended]
This study is being done to find out if a drug called Rituxan (Rituximab) is safe and
effective in treating people with chronic urticaria (hives) with persistent symptoms in spite
of taking antihistamines.
Reports of Suspected Rituxan (Rituximab) Side Effects
Progressive Multifocal Leukoencephalopathy (20),
Rash (16), more >>