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Risperdal Consta (Risperidone) - Summary

 
 



Increased Mortality in Elderly Patients with Dementia –Related Psychosis

Elderly patients with dementia-related psychosis treated with atypical antipsychotic drugs are at an increased risk of death compared to placebo. Analyses of seventeen placebo controlled trials (modal duration of 10 weeks) in these patients revealed a risk of death in the drug-treated patients of between 1.6 to 1.7 times that seen in placebo-treated patients. Over the course of a typical 10 week controlled trial, the rate of death in drug-treated patients was about 4.5%, compared to a rate of about 2.6% in the placebo group. Although the causes of death were varied, most of the deaths appeared to be either cardiovascular (e.g., heart failure, sudden death) or infectious (e.g., pneumonia) in nature. RISPERDAL ® CONSTA ® (risperidone) is not approved for the treatment of patients with Dementia-Related Psychosis.

 

SUMMARY

JANSSEN, L.P.
RISPERDAL® CONSTA®
(risperidone)
LONG-ACTING INJECTION

RISPERDAL® (risperidone) is a psychotropic agent belonging to the chemical class of benzisoxazole derivatives. The chemical designation is 3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one.

RISPERDAL® CONSTA®(risperidone) is indicated for the treatment of schizophrenia.

The efficacy of RISPERDAL® CONSTA® is based in part on a 12-week, placebo-controlled trial in schizophrenic inpatients or outpatients, along with extrapolation from the established efficacy of oral RISPERDAL® in this population.

The effectiveness of RISPERDAL® CONSTA® in longer-term use, that is, more than 12 weeks, has not been systematically evaluated in controlled trials. However, oral risperidone has been shown to be effective in delaying time to relapse in longer-term use. Patients should be periodically reassessed to determine the need for continued treatment (see DOSAGE AND ADMINISTRATION ).


See all Risperdal Consta indications & dosage >>

NEWS HIGHLIGHTS

Published Studies Related to Risperdal Consta (Risperidone)

Double-blind, placebo-controlled trial of risperidone plus amantadine in children with autism: a 10-week randomized study. [2013]
risperidone for treatment of autism... CONCLUSIONS: The present study suggests that amantadine may be a potential

Memantine add-on to risperidone for treatment of negative symptoms in patients with stable schizophrenia: randomized, double-blind, placebo-controlled study. [2013]
We aimed to evaluate the efficacy of memantine add-on in the treatment of primary negative symptoms of patients with stable schizophrenia. In a double-blind placebo-controlled clinical trial, 40 patients with schizophrenia (Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition) who were stabilized on risperidone for a minimum of 8 weeks were randomized to either memantine (20 mg) or placebo in addition to risperidone, 6 mg/d, for eight weeks...

Risperidone dosing in children and adolescents with autistic disorder: a double-blind, placebo-controlled study. [2013]
Efficacy and safety of 2 risperidone doses were evaluated in children and adolescents with autism. Patients (N = 96; 5-17 years), received risperidone (low-dose: 0.125 mg/day [20 to <45 kg], 0.175 mg/day [>45 kg] or high-dose: 1.25 mg/day [20 to <45 kg], 1.75 mg/day [>45 kg]) or placebo...

Memantine as adjunctive treatment to risperidone in children with autistic disorder: a randomized, double-blind, placebo-controlled trial. [2013]
Autism is a neurodevelopmental disorder that causes significant impairment in socialization and communication. It is also associated with ritualistic and stereotypical behaviour... The present study suggests that memantine may be a potential adjunctive treatment strategy for autism and it was generally well tolerated.

Characteristics of responders and non-responders to risperidone monotherapy or placebo in co-occurring bipolar disorder and anxiety disorder. [2013]
Clinical characteristics predicting response and remission to psychopharmacological treatment of bipolar disorder (BD) and co-occurring anxiety disorders have been understudied. We hypothesized that non-response to risperidone or placebo in individuals with co-occurring BD and anxiety symptoms would be associated with a more severe clinical course of BD, and certain demographic variables...

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Clinical Trials Related to Risperdal Consta (Risperidone)

Evaluation of the Usefulness to Doctors of the Risperdal Consta Treatment Guidebook Over a Three-Month Period During Which Adult Patients With Schizophrenia or Schizoaffective Disorder Are Switching From Daily Doses or Risperidone Tablets to Long-Acting Risperidone by Injection [Completed]
The purpose of this study is to assess the usefulness of the Risperdal Consta Treatment Guidebook in helping the doctor switch the adult patient from taking risperidone tablets daily by mouth to taking long-acting risperidone by injection. The study will also evaluate the effectiveness and safety of long-acting risperidone and its effect on patient satisfaction.

Oral Versus Injectable Risperidone for Treating First-Episode Schizophrenia [Recruiting]
This study will determine the effectiveness of oral risperidone versus long-acting injectable risperidone in treating people with first-episode schizophrenia.

Risperdal Consta for Bipolar Disorder [Active, not recruiting]
We are recruiting 50 consenting adult subjects with DSM-IV TR diagnoses of bipolar disorder who are about to initiate or switch their current antipsychotic agent. Patients are titrated and cross-tapered during a 3 month titration and stabilization phase. Presently 4 of the 11 subjects enrolled have transitioned successfully and are in Phase III of the study. After transitioning into the next phase, they will be followed for an additional 12 months. Clinical outcomes such as study drop out, adverse events, worsening of symptoms, crisis interventions, need for additional medication, hospitalizations etc. will be evaluated from months 3 to 15 (visits 8-20). The time to clinical events will be used to evaluate if the long acting injectable form of risperidone has an advantage over the oral second generation antipsychotic agents in terms of treatment continuity and clinical stability.

A Study of How Long it Takes a Patient to Relapse After Switching From an Oral Antipsychotic to One of Two Doses of Long-Acting Risperidone Injections in Patients With Schizophrenia or Schizoaffective Disorder [Completed]
The purpose of this study is to assess the time for patients to relapse when switched from an oral antipsychotic to one of two doses of long-acting risperidone injection (shots). Risperidone has been used successfully to treat schizophrenia and schizoaffective disorder.

Safety and Efficacy of Zicronapine in Patients With Schizophrenia [Recruiting]
To assess the effect of zicronapine versus risperidone on metabolic parameters comprising body weight, body mass index (BMI), waist circumference, levels of fasting blood lipids and glucose during 6 months of treatment.

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Reports of Suspected Risperdal Consta (Risperidone) Side Effects

Hospitalisation (49)Drug Ineffective (35)Weight Increased (35)Inappropriate Schedule of Drug Administration (32)Psychotic Disorder (32)Product Quality Issue (30)Condition Aggravated (28)Gait Disturbance (28)Depression (27)Abnormal Behaviour (27)more >>


PATIENT REVIEWS / RATINGS / COMMENTS

Based on a total of 3 ratings/reviews, Risperdal Consta has an overall score of 6. The effectiveness score is 6.67 and the side effect score is 6.67. The scores are on ten point scale: 10 - best, 1 - worst.
 

Risperdal Consta review by 27 year old female patient

  Rating
Overall rating:  
Effectiveness:   Considerably Effective
Side effects:   No Side Effects
  
Treatment Info
Condition / reason:   psychotic symptoms
Dosage & duration:   1 mg taken twice a day for the period of 2 years - currently
Other conditions:   depression
Other drugs taken:   Fluoxetine
  
Reported Results
Benefits:   Psychotic thoughts went away. No longer thought people were out to get me. Became less suspicious of people. Iritability decreaed while on this medication. This medication has worked wonders for me.
Side effects:   None at all for me. I have tolerated this medication very well.
Comments:   Started this medication in October 2008 for my suspiciousness of people (thought people were out to get me). Began at 0.25 mg once a day for a week, then increased to 0.5 mg a day at night. 3 weeks later (1 month from the time of starting risperidone), increased to 1 mg every night. Stayed on 1 mg for a few months when the symptoms came back. Dose increased to 1.5 mg a day. Depression set in (for outside life factors...not due to medication) and fluoetime added at 10 mg a day and risperidone decreased to 1 mg a day due to flueoxetine increasing the levels of risperidone. Depression still there and psychotic symptoms came back. At next vist (1 month) flueoxetine increased to 20 mg every morning and risperidone increased back to 1.5 mg a day. Two months later psychotic symptoms would come back in the middle of the day (as if the medication was wearing off). Rispreridone dosage changed to 1 mg twice a day. Which is still the current dosage I am on.

 

Risperdal Consta review by 25 year old male patient

  Rating
Overall rating:  
Effectiveness:   Marginally Effective
Side effects:   Moderate Side Effects
  
Treatment Info
Condition / reason:   bipolar
Dosage & duration:   4mgs taken 5 years for the period of 5 years
Other conditions:   N/A
Other drugs taken:   Lithium
  
Reported Results
Benefits:   depression lessened
Side effects:   headaches after 4 years, no control over breathing, the drug created inner emotions and feeling that weren't present before starting taking the medication, the bi-treatment of lithium and risperidone also created feeling of excessive sleepiness, created a weight gain of more than my normal size, colors of objects turn more bland and life seems more pointless when taking risperidone during the day. Taking the medication at bedtime turned out to be better. Smoke 2 packs a day after taking the medication at night and waking up the next day. Less able to control emotions.
Comments:   I had more energy than others when i was younger and the doctors and parents wanted to punish me for it by putting me on medication. Havn't been able to get off them since because they are addicting and mind warping.

 

Risperdal Consta review by 25 year old male patient

  Rating
Overall rating:  
Effectiveness:   Marginally Effective
Side effects:   Moderate Side Effects
  
Treatment Info
Condition / reason:   bipolar
Dosage & duration:   4mgs taken 5 years for the period of 5 years
Other conditions:   N/A
Other drugs taken:   Lithium
  
Reported Results
Benefits:   depression lessened
Side effects:   headaches after 4 years, no control over breathing, the drug created inner emotions and feeling that weren't present before starting taking the medication, the bi-treatment of lithium and risperidone also created feeling of excessive sleepiness, created a weight gain of more than my normal size, colors of objects turn more bland and life seems more pointless when taking risperidone during the day. Taking the medication at bedtime turned out to be better. Smoke 2 packs a day after taking the medication at night and waking up the next day. Less able to control emotions.
Comments:   I had more energy than others when i was younger and the doctors and parents wanted to punish me for it by putting me on medication. Havn't been able to get off them since because they are addicting and mind warping.

See all Risperdal Consta reviews / ratings >>

Page last updated: 2014-12-01

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