NEWS HIGHLIGHTS
Published Studies Related to Rimso-50 (Dimethyl Sulfoxide)
Dimethyl sulfoxide with lignocaine versus eutectic mixture of local anesthetics: prospective randomized study to compare the efficacy of cutaneous anesthesia in shock wave lithotripsy. [2011.06]
The objective of the study was to compare the efficacy of dimethyl sulfoxide (DMSO) mixed with lignocaine and eutectic mixture of local anesthetics (EMLA) cream as topically applied surface anesthetics in relieving pain during shock wave lithotripsy (SWL) in a prospective randomized study...
Effects of therapeutic pulsed ultrasound and dimethylsulfoxide (DMSO) phonophoresis on parameters of oxidative stress in traumatized muscle. [2010.01]
Many studies have demonstrated an increase in reactive oxygen species (ROS) and oxidative damage markers after muscle damage. Phonophoresis aims to achieve therapeutically relevant concentrations of the transdermally introduced drug in the tissues subjected to the procedure by the use ultrasound waves...
Evaluation of efficacy and safety of zinc gluconate associated with dimethyl sulphoxide for sexually mature canine males chemical neutering. [2009.12]
The aim of this research was to evaluate the efficacy of zinc gluconate associated with dimethyl sulphoxide (DMSO) for chemical neutering in canine males. Fifteen sexually mature male dogs were divided in two groups, named control and treated... Ultrasound and histopathology analyses of testicles for the treated group revealed more intense injuries when compared with the control group, with compromised testicular parenchyma and a decrease of germ cell number leading to total atrophy, indicating that the treatment reduced the fertilizing potential of male dogs, promoting a possible subfertile status.
Botulinum a toxin/dimethyl sulfoxide bladder instillations for women with refractory idiopathic detrusor overactivity: a phase 1/2 study. [2009.08]
We completed a phase 1/2 trial to evaluate the safety and potential efficacy of direct intravesical instillation of a botulinum type A toxin/dimethyl sulfoxide (DMSO) solution for treatment of idiopathic detrusor overactivity in women. Twenty-five women with medication-resistant, urodynamic-confirmed idiopathic detrusor overactivity were enrolled...
Synthesis and detection of toltrazuril sulfone and its pharmacokinetics in horses following administration in dimethylsulfoxide. [2009.08]
Triazine-based antiprotozoal agents are known for their lipophylic characteristics and may therefore be expected to be well absorbed following oral administration. However, although an increase in lipid solubility generally increases the absorption of chemicals, extremely lipid-soluble chemicals may dissolve poorly in gastrointestinal (GI) fluids, and their corresponding absorption and bioavailability would be low...
Clinical Trials Related to Rimso-50 (Dimethyl Sulfoxide)
Phase 1 Safety Study of Dimethyl Sulfoxide Cryopreserved Platelets [Recruiting]
This study is to evaluate the safety of intravenous (IV) infusion of dimethyl sulfoxide
(DMSO) cryopreserved platelets (CPP) in participants with World Health Organization (WHO)
Grade 2 bleed in spite of receiving a transfusion of liquid stored platelets (LSP) in the
past 48 hours by collecting adverse events (AEs) and by evaluating coagulation-related
parameters to assess the evidence of any thrombotic events after CPP or LSP transfusion.
Comparative Study Between Hyperbaric Therapy and Intravesical Dimethyl Sulfoxide Instillation for Interstitial Cystitis [Recruiting]
The purpose of this study is to compare the efficacy of hyperbaric oxygen therapy (HBOT) to
intravesical Dimethyl Sulfoxide (DMSO) instillation for the treatment of patients who
suffers from Interstitial Cystitis / Painful bladder syndrome.
DMSO for Prevention of Capsular Contraction in Alloplastic Breast Reconstruction [Not yet recruiting]
Capsular contraction is the one of the most common complications of both esthetic and
reconstructive breast surgery, with high incidence after radiotherapy. The mechanism of the
contraction is unclear, but is believed to be similar to the formation of hypertrophic
scarring.
Dimethyl sulfoxide (DMSO) has demonstrated its use as an anti-inflammatory,
anti-proliferative, and antibacterial agent.
The aim of this study is to test the effect of DMSO on the incidence and severity if
capsular contracture after breast alloplastic reconstruction in irradiated patients.
We conduct a prospective randomized-control single-surgeon study in the tertiary academic
Rabin Medical Center.
110 female candidates for mastectomy, radiotherapy and immediate two-stage reconstruction
will be included. They will be divided into two groups: the DMSO treatment group, which will
be treated according to our protocol, and the control group, that will be treated with the
same protocol but with 0. 9% saline instead.
Several measures will be taken, including: capsular contracture grading by two plastic
surgeons, a VAS-score of breast pain, maximal capsular thickness (MCT) in sonography
evaluation, and pathology examination of the capsule (biopsy will be taken during the second
stage operation).
Rates and grades of capsular contracture evident clinically, radiologically and
pathologically, will be evaluated and compared.
Trial Comparing Intravesical Cocktail With Intravesical Dimethyl Sulfoxide (DMSO) in Painful Bladder Syndrome/Interstitial Cystitis (PBS/IC) [Terminated]
The primary objective of this study is to evaluate the efficacy and tolerability of the
intravesical cocktail and its comparison with intravesical DMSO in a controlled trial for
the treatment of painful bladder syndrome including interstitial cystitis.
Botulin-A Toxin Instillations and Overactive Bladder [Completed]
The primary objective of this pilot study is to evaluate the safety and efficacy of direct
instillations of Botulinum-A toxin/DMSO into the bladder via a catheter system as a means of
treating women with symptoms of overactive bladder and secondary urinary incontinence. In
doing so, we will focus on estimating the percentage of women who experience an improvement
in their urinary incontinence symptoms at one month and three months following this novel
instillation technique.
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