Ridaura (Auranofin) - Drug Interactions, Contraindications, Overdosage

DRUG INTERACTIONS

Drug Interactions: In a single patient-report, there is the suggestion that concurrent administration of Ridaura and phenytoin may have increased phenytoin blood levels.

OVERDOSAGE

The acute oral LD50 for auranofin is 310 mg/kg in adult mice and 265 mg/ kg in adult rats. The minimum lethal dose in rats is 30 mg/kg.

In case of acute overdosage, immediate induction of emesis or gastric lavage and appropriate supportive therapy are recommended.

Ridaura overdosage experience is limited. A 50-year-old female, previously on 6 mg Ridaura daily, took 27 mg (9 capsules) daily for 10 days and developed an encephalopathy and peripheral neuropathy. Ridaura was discontinued and she eventually recovered.

There has been no experience with treating Ridaura overdosage with modalities such as chelating agents. However, they have been used with injectable gold and may be considered for Ridaura overdosage.

CONTRAINDICATIONS

Ridaura (auranofin) is contraindicated in patients with a history of any of the following gold-induced disorders: anaphylactic reactions, necrotizing enterocolitis, pulmonary fibrosis, exfoliative dermatitis, bone marrow aplasia or other severe hematologic disorders.