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Ribavirin (Ribavirin) - Drug Interactions, Contraindications, Overdosage, etc

 
 



DRUG INTERACTIONS

RIBAVIRIN drug label information in our database does not contain a dedicated section on drug interactions. Please check subsections of WARNINGS AND PRECAUTIONS as well as other sources.

OVERDOSAGE

No cases of overdose with ribavirin tablets have been reported in clinical trials.    Hypocalcemia and hypomagnesemia have been observed in persons administered greater than the recommended dosage of ribavirin. In most of these cases, ribavirin was administered intravenously at dosages up to and in some cases exceeding four times the recommended maximum oral daily dose.

CONTRAINDICATIONS

Ribavirin tablet is contraindicated in:

  • Patients with known hypersensitivity to ribavirin tablets or to any component of the tablet.
  • Women who are pregnant.
  • Men whose female partners are pregnant.
  • Patients with hemoglobinopathies (e.g., thalassemia major or sickle-cell anemia).
  • Ribavirin tablets and peginterferon alfa-2a combination therapy is contraindicated in patients with:

  • Autoimmune hepatitis.
  • Hepatic decompensation (Child-Pugh score greater than 6; class B and C) in cirrhotic CHC monoinfected patients before or during treatment.
  • Hepatic decompensation with Child-Pugh score greater than or equal to 6 in cirrhotic CHC patients coinfected with HIV before or during treatment.
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