Rhogam (IgG Anti-D (Anti-Rh)) - Summary

RHOGAM SUMMARY

RhoGAM® and MICRhoGAM® Rh_o(D) Immune Globulin (Human) are sterile solutions containing IgG anti-D (anti-Rh) for use in preventing Rh immunization.

The indications are the following:

PREGNANCY AND OTHER OBSTETRICAL CONDITIONS IN RH-NEGATIVE WOMEN, UNLESS THE FATHER OR BABY ARE CONCLUSIVELY RH NEGATIVE

• Pregnancy/delivery of an Rh-positive baby irrespective of the ABO groups of the mother and baby
• Abortion/threatened abortion at any stage of gestation
• Ectopic pregnancy
• Antepartum fetal-maternal hemorrhage (suspected or proven) resulting from antepartum hemorrhage (e.g., placenta previa), amniocentesis, chorionic villus sampling, percutaneous umbilical blood sampling, other obstetrical manipulative procedure (e.g., version) or abdominal trauma
• Transfusion of Rh incompatible blood or blood products

TRANSFUSION

• Prevention of Rh immunization in any Rh-negative person after incompatible transfusion of Rh-positive blood or blood products (e.g., red cells, platelet concentrates, granulocyte concentrates)

RHOGAM NEWS HIGHLIGHTS

Published Studies Related to Rhogam (IgG Anti-D)

Dual inhibition of the epidermal growth factor receptor with cetuximab, an IgG1 monoclonal antibody, and gefitinib, a tyrosine kinase inhibitor, in patients with refractory non-small cell lung cancer (NSCLC): a phase I study. [2008.03]

Kinetics of the immune response following pneumococcal PD conjugate vaccination. [2007.03.01]

Pharmacokinetics of anti-D IgG in pregnant RhD-negative women. [2003.01]

IgG-mediated immunosuppression is not dependent on erythrocyte clearance or immunological evasion: implications for the mechanism of action of anti-D in the prevention of haemolytic disease of the newborn? [2007.10]

Binding kinetics, uptake and intracellular accumulation of F105, an anti-gp120 human IgG1kappa monoclonal antibody, in HIV-1 infected cells. [2007.01]

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Clinical Trials Related to Rhogam (IgG Anti-D)

A Trial of the Pharmacokinetics, Safety, and Tolerability of Subcutaneous Gamunex® in Primary Immunodeficiency [Active, not recruiting]

Trial of the Efficacy of Intravenous Immunoglobulin for Treating Women With Unexplained Secondary Recurrent Miscarriage [Not yet recruiting]

Intravenous Immunoglobulin (IVIG) for Treatment of Unexplained Secondary Recurrent Miscarriage [Active, not recruiting]

Intravenous Immunoglobulin After Relapse in Vasculitis [Terminated]

Immune Globulin Intravenous (IGIV) For Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) [Completed]

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