Media Articles Related to Reyataz (Atazanavir)
HIV infections up by 8% across Europe more testing and better treatment coverage recommended
Source: Health News from Medical News Today [2013.11.28]
According to new data issued by the European Centre for Disease Prevention and Control (ECDC) and the WHO Regional Office for Europe, more than 131 000 new HIV infections were reported in the WHO European Region in 2012: 10 000 (8%) more than in 2011. This confirms a steady increase across the Region over that year: a 9% rise in countries in eastern Europe and central Asia (EECA) and a less than 1% rise in countries in the European Union and European Economic Area (EU/EEA). Of the new HIV infections in the Region, almost 102 000 were reported in the EECA and over 29 000 in the EU/EEA.
Primary care key to management of patients with HIV infection
Source: HIV / AIDS News From Medical News Today [2013.11.14]
The HIV Medicine Association (HIVMA) of the Infectious Diseases Society of America (IDSA) has updated its HIV care guidelines to reflect the fact that people with HIV are now living normal life spans, and their physicians need to focus on preventive care, including screening for high cholesterol, diabetes and osteoporosis.
Baby "Cured" of HIV Infection
Source: MedicineNet nevirapine Specialty [2013.04.03]
Title: Baby "Cured" of HIV Infection
Category: Doctor's & Expert's views on Symptoms
Created: 4/3/2013 6:12:00 PM
Last Editorial Review: 4/3/2013 6:12:53 PM
PodMed: A Medical News Roundup from Johns Hopkins (with audio)
Source: MedPageToday.com - medical news plus CME for physicians [2013.11.29]
(MedPage Today) -- This week's topics include the history of immunization and preventable infection, HIV vaccine candidate disappoints, kids with Crohn's, and micronutrients in HIV infection.
Supplement Combo Lessens HIV Progression (CME/CE)
Source: MedPage Today Infectious Disease [2013.11.26]
(MedPage Today) -- Early in HIV infection, a combination of multivitamin and selenium supplements slowed the progress of the disease, researchers reported.
Published Studies Related to Reyataz (Atazanavir)
Determination of rifabutin dosing regimen when administered in combination with ritonavir-boosted atazanavir. [2011.09]
OBJECTIVES: Treatment of HIV/tuberculosis (TB) co-infected patients is complex due to drug-drug interactions for these chronic diseases. This study evaluates an intermittent dosing regimen for rifabutin when it is co-administered with ritonavir-boosted atazanavir... CONCLUSIONS: The benefits to HIV/TB co-infected patients receiving rifabutin 150 mg three times weekly or every other day may outweigh the risks of neutropenia observed here in non-HIV-infected subjects, provided that patients on combination therapy will be closely monitored for safety and tolerability.
Peripheral and central fat changes in subjects randomized to abacavir-lamivudine or tenofovir-emtricitabine with atazanavir-ritonavir or efavirenz: ACTG Study A5224s. [2011.07.15]
BACKGROUND: We compare the effect of 4 different antiretroviral regimens on limb and visceral fat... CONCLUSIONS: ABC-3TC- and TDF-FTC-based regimens increased limb and visceral fat at week 96, with a similar prevalence of lipoatrophy. Compared to the EFV group, subjects assigned to ATV-r had a trend towards higher mean percentage increase in VAT. CLINICAL TRIALS REGISTRATION: NCT00118898.
Lipid profiles for nevirapine vs. atazanavir/ritonavir, both combined with tenofovir disoproxil fumarate and emtricitabine over 48 weeks, in treatment-naive HIV-1-infected patients (the ARTEN study). [2011.07]
OBJECTIVES: Dyslipidaemic effects of antiretrovirals (ARVs) may contribute to increased cardiovascular risk (CR) in HIV-1-infected patients. The ARTEN (atazanavir/ritonavir on a background of tenofovir and emtricitabine vs. nevirapine on the same background, in naive HIV-1-infected patients) study compared prospectively ritonavir-boosted atazanavir (ATZ/r) 300 mg/100 mg once daily (qd) with immediate release nevirapine (NVP) 200 mg twice daily or 400 mg qd, each combined with fixed-dose tenofovir 300 mg/emtricitabine 200 mg qd in 569 ARV-naive HIV-1-infected patients. Lipid profiles and CR from baseline to week 48 are reported... CONCLUSIONS: In ARV-naive patients with low CR at the outset, NVP showed a potentially less atherogenic lipid profile compared with ATZ/r. (c) 2011 British HIV Association.
Bone mineral density and fractures in antiretroviral-naive persons randomized to receive abacavir-lamivudine or tenofovir disoproxil fumarate-emtricitabine along with efavirenz or atazanavir-ritonavir: Aids Clinical Trials Group A5224s, a substudy of ACTG A5202. [2011.06.15]
BACKGROUND: Long-term effects of abacavir (ABC)-lamivudine (3TC), compared with tenofovir (TDF)-emtricitabine (FTC) with efavirenz (EFV) or atazanavir plus ritonavir (ATV/r), on bone mineral density (BMD) have not been analyzed... CONCLUSIONS: Compared with ABC-3TC, TDF-FTC-treated participants had significantly greater decreases in spine and hip BMD, whereas ATV/r led to more significant losses in spine, but not hip, BMD than EFV. Clinical Trials Registration. NCT00118898.
Atazanavir plus ritonavir or efavirenz as part of a 3-drug regimen for initial treatment of HIV-1. [2011.04.05]
BACKGROUND: Limited data compare once-daily options for initial therapy for HIV-1. OBJECTIVE: To compare time to virologic failure; first grade-3 or -4 sign, symptom, or laboratory abnormality (safety); and change or discontinuation of regimen (tolerability) for atazanavir plus ritonavir with efavirenz-containing initial therapy for HIV-1... CONCLUSION: Atazanavir plus ritonavir and efavirenz have similar antiviral activity when used with abacavir-lamivudine or tenofovir DF-emtricitabine. PRIMARY FUNDING SOURCE: National Institutes of Health. (c) 2011 American College of Physicians
Clinical Trials Related to Reyataz (Atazanavir)
Atazanavir Twice Daily [Completed]
The purpose of this clinical research study is to assess the pharmacokinetics of atazanavir
administered twice-daily relative to historical data from atazanavir/ritonavir 300/100 mg,
given once daily.
Atazanavir (BMS-232632) in Combination With Ritonavir or Saquinavir, and Lopinavir/Ritonavir, Each With Tenofovir and a Nucleoside in Subjects With HIV [Active, not recruiting]
The purpose of this study is to learn how well atazanavir works in combination with ritonavir
or saquinavir with tenofovir and a nucleoside to reduce the viral load of treatment
experienced subjects with HIV. There is a comparison arm with lopinavir/ritonavir and
tenofovir and a nucleoside.
Drug Interaction Study With Atazanavir Administered With and Without Ritonavir and a Cytochrome P450 Substrate Rosiglitazone [Completed]
Drug Interaction Study With Proton Pump Inhibitor [Completed]
The purpose of this clinical research study is to assess the effect of omeprazole at 20 mg on
the pharmacokinetics of atazanavir administered as atazanavir with ritonavir relative to
atazanavir or atazanavir/ritonavir in the absence of omeprazole in healthy subjects.
Dose Finding Confirmation of Atazanavir With Ritonavir and Efavirenz (ATV/RTV + EFV) in Healthy Subjects [Completed]
The purpose of this study is to assess the exposure of Atazanavir 400 mg with Ritonavir 100
mg and with Efavirenz 600 mg compared to Atazanavir 300 mg with 100 mg without Efavirenz in
Reports of Suspected Reyataz (Atazanavir) Side Effects
Foetal Exposure During Pregnancy (102),
Maternal Exposure During Pregnancy (66),
Abortion Spontaneous (64),
Renal Failure Acute (35),
Abortion Induced (33),
Viral Load Increased (31),
Jaundice (23), more >>