REVEX SUMMARY
REVEX (nalmefene hydrochloride injection)
Rx only
REVEX (nalmefene hydrochloride injection), an opioid antagonist, is a 6-methylene analogue of naltrexone.
REVEX is indicated for the complete or partial reversal of opioid drug effects, including respiratory depression, induced by either natural or synthetic opioids.
REVEX is indicated in the management of known or suspected opioid overdose.
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NEWS HIGHLIGHTS
Published Studies Related to Revex (Nalmefene)
Effects of opioid receptor gene variation on targeted nalmefene treatment in heavy drinkers. [2008.07]
BACKGROUND: Recent studies examining the moderating effects of polymorphic variation in opioid receptor genes have yielded conflicting results. We examined opioid receptor gene polymorphisms as moderators of the therapeutic effects of the opioid antagonist nalmefene... CONCLUSIONS: Our finding that the therapeutic effects of targeted nalmefene were not moderated by polymorphic variation in opioid receptor genes is consistent with two recent reports showing that variation in opioid receptor genes does not moderate the response to naltrexone. However, these findings contrast with those from two other studies, in which the Asn40Asp polymorphism in OPRM1 moderated the naltrexone treatment response. Additional research is needed to clarify the role of variation in opioid receptor genes on the response to opioid antagonist treatment of alcoholism.
Effects of Opioid Receptor Gene Variation on Targeted Nalmefene Treatment in Heavy Drinkers. [2008.06.03]
Recent studies examining the moderating effects of polymorphic variation in opioid receptor genes have yielded conflicting results...
Targeted nalmefene with simple medical management in the treatment of heavy drinkers: a randomized double-blind placebo-controlled multicenter study. [2007.07]
BACKGROUND: Clinical studies with opioid antagonists for treatment of problem drinking have mainly been conducted in specialized alcohol treatment centers, included structured psychosocial treatment, and have focused on maintaining abstinence after a period of abstinence from alcohol... CONCLUSIONS: Nalmefene appears to be effective and safe in reducing heavy drinking, even when accompanied by minimal psychosocial support.
Multicenter investigation of the opioid antagonist nalmefene in the treatment of pathological gambling. [2006.02]
CONCLUSIONS: Subjects who received nalmefene had a statistically significant reduction in severity of pathological gambling. Low-dose nalmefene (25 mg/day) appeared efficacious and was associated with few adverse events. Higher doses (50 mg/day and 100 mg/day) resulted in intolerable side effects.
[Pharmacokinetics of nalmefene after a single or multiple intravenous doses in Chinese healthy volunteers.] [2008.10]
OBJECTIVE: To investigate the pharmacokinetics of nalmefene after intravenous administration at a single or multiple doses in Chinese healthy volunteers... CONCLUSION: Nalmefene showed similar pharmacokinetics in Chinese healthy volunteers with those in the foreign testees, and can be safely administered in healthy volunteers without producing unmanageable pain.
Clinical Trials Related to Revex (Nalmefene)
Nalmefene Smoking Cessation Study [Completed]
Nalmefene Gambling Study: Study of Nalmefene HCl in the Treatment of Pathological Gambling [Completed]
Efficacy of Nalmefene in Patients With Alcohol Dependence [Recruiting]
Efficacy of Nalmefene in Patients With Alcohol Dependence [Recruiting]
Safety of Nalmefene in Patients With Alcohol Dependence [Recruiting]
The purpose of the study is long-term safety and tolerability of nalmefene in patients with
alcohol dependence.
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