Retrovir (Zidovudine) - Summary

RETROVIR SUMMARY

RETROVIR®
(zidovudine)
Tablets
RETROVIR®
(zidovudine)
Capsules
RETROVIR®
(zidovudine)
Syrup

RETROVIR is the brand name for zidovudine (formerly called azidothymidine [AZT]), a pyrimidine nucleoside analogue active against human immunodeficiency virus (HIV).

RETROVIR in combination with other antiretroviral agents is indicated for the treatment of HIV infection.

Maternal-Fetal HIV Transmission: RETROVIR is also indicated for the prevention of maternal-fetal HIV transmission as part of a regimen that includes oral RETROVIR beginning between 14 and 34 weeks of gestation, intravenous RETROVIR during labor, and administration of RETROVIR Syrup to the neonate after birth. The efficacy of this regimen for preventing HIV transmission in women who have received RETROVIR for a prolonged period before pregnancy has not been evaluated. The safety of RETROVIR for the mother or fetus during the first trimester of pregnancy has not been assessed (see Description of Clinical Studies).

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RETROVIR NEWS HIGHLIGHTS

Media Articles Related to Retrovir (Zidovudine)

Togo Begins Distributing No-Cost Antiretrovirals, Government Says
Source: Aid / Disasters News From Medical News Today [2008.11.19]

New HIV/AIDS Treatment SELZENTRY™ Becomes The Latest Fully Approved Antiretrovial For Treatment-Experienced HIV Patients
Source: HIV / AIDS News From Medical News Today [2008.11.27]

Universal HIV Testing Could Halt AIDS In Epidemic Areas, In Theory
Source: HIV / AIDS News From Medical News Today [2008.11.26]

Universal Testing, Prompt Treatment Could Slash HIV (HealthDay)
Source: Y! Health HIV & AIDS News [2008.11.26]

Faulty AIDS policies caused 365,000 early deaths in SAfrica: study (AFP)
Source: Y! Health HIV & AIDS News [2008.11.26]

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Published Studies Related to Retrovir (Zidovudine)

Phase II study of vicriviroc versus efavirenz (both with zidovudine/lamivudine) in treatment-naive subjects with HIV-1 infection. [2008.10.15]

Didanosine, lamivudine, and efavirenz versus zidovudine, lamivudine, and efavirenz for the initial treatment of HIV type 1 infection: final analysis (48 weeks) of a prospective, randomized, noninferiority clinical trial, GESIDA 3903. [2008.10.15]

A randomized trial of combination hepatitis B therapy in HIV/HBV coinfected antiretroviral naive individuals in Thailand. [2008.10]

HIV-1 persists in breast milk cells despite antiretroviral treatment to prevent mother-to-child transmission. [2008.07.31]

Extended antiretroviral prophylaxis to reduce breast-milk HIV-1 transmission. [2008.07.10]

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Clinical Trials Related to Retrovir (Zidovudine)

Trial of Maraviroc (UK-427,857) in Combination With Zidovudine/Lamivudine Versus Efavirenz in Combination With Zidovudine/Lamivudine [Active, not recruiting]

A Randomized Trial to Evaluate the Safety and Efficacy of Combination Therapy With Retrovir ( AZT ) and HIVID ( ddC ) Versus Retrovir, HIVID, and Wellferon ( Interferon Alfa-n1 ) for the Treatment of HIV Infection [Completed]

A Multi-Center, Placebo-Controlled, Double-Blind, Randomized Trial Comparing the Virologic and Immunologic Activities of 400 Mg Nevirapine in Combination With Zidovudine Versus Zidovudine Alone in Asymptomatic HIV-1 Infected Patients With 4-12 Months of Prior Zidovudine Therapy and 200-500 CD4+ Cell [Completed]

A Pilot Study To Evaluate the Effect of Retrovir (Zidovudine: AZT) in the Treatment of Human Immunodeficiency Virus (HIV) Associated Dementia and Neuromuscular Diseases [Completed]

A Treatment IND for Retrovir Brand Zidovudine (AZT) Therapy of Pediatric Patients With HIV Disease [Active, not recruiting]

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