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Retin-A (Tretinoin Topical) - Summary



Cream · Gel · Liquid

RETIN-A Gel, Cream and Liquid, containing tretinoin are used for the topical treatment of acne vulgaris. RETIN-A Gel contains tretinoin (retinoic acid, vitamin A acid) in either of two strengths, 0.025% or 0.01% by weight, in a gel vehicle of butylated hydroxytoluene, hydroxypropyl cellulose and alcohol (denatured with tert- butyl alcohol and brucine sulfate) 90% w/w. RETIN-A (tretinoin) Cream contains tretinoin in either of three strengths, 0.1%, 0.05%, or 0.025% by weight, in a hydrophilic cream vehicle of stearic acid, isopropyl myristate, polyoxyl 40 stearate, stearyl alcohol, xanthan gum, sorbic acid, butylated hydroxytoluene, and purified water. RETIN-A Liquid contains tretinoin 0.05% by weight, polyethylene glycol 400, butylated hydroxytoluene and alcohol (denatured with tert- butyl alcohol and brucine sulfate) 55%.

RETIN-A is indicated for topical application in the treatment of acne vulgaris. The safety and efficacy of the long-term use of this product in the treatment of other disorders have not been established.

See all Retin-A indications & dosage >>


Published Studies Related to Retin-A (Tretinoin Topical)

Effect of Aloe vera topical gel combined with tretinoin in treatment of mild and moderate acne vulgaris: a randomized, double-blind, prospective trial. [2014]
CONCLUSION: The combination TR/AVG was well tolerated and significantly more

Tretinoin cyclodextrin complex (RA/CyD) causes less irritation with an equal antiwrinkle effect compared with conventional tretinoin: clinical and histologic studies of photoaged skin. [2012]
the side effects compared with RA treatment alone... CONCLUSION: The findings show that RA and RA/CyD result in the equivalent

A randomized, double-blind, placebo-controlled, pilot study to assess the efficacy and safety of clindamycin 1.2% and tretinoin 0.025% combination gel for the treatment of acne rosacea over 12 weeks. [2012]
rosacea after 12 weeks of usage... CONCLUSIONS: A combination gel of clindamycin phosphate 1.2% and tretinoin 0.025%

A randomized, double-blind, controlled comparative trial of the anti-aging properties of non-prescription tri-retinol 1.1% vs. prescription tretinoin 0.025%. [2012]
Vitamin A and its derivatives (commonly termed retinoids) are widely used in topical anti-aging products. Certain retinoids such as retinol and its esters are available without a prescription, while others such as tretinoin are available only via prescription... Subjects reported >93 percent overall satisfaction with both products at weeks 8 and 12.

Retinoic acid reduces chemotherapy-induced neuropathy in an animal model and patients with lung cancer. [2011.09.06]
OBJECTIVE: To evaluate the effect of all-trans retinoic acid (ATRA) as treatment for chemotherapy-induced peripheral neuropathy in an experimental animal model and in a randomized, double-blinded, controlled trial in patients with non-small-cell lung cancer (NSCLC)... CONCLUSIONS: ATRA reduced chemotherapy-induced experimental neuropathy, increased NGF levels, and induced RAR-beta expression in nerve. In patients, reduction of NGF in serum was associated with the severity of neuropathy; ATRA treatment reduced the electrophysiologic alterations. Classification of evidence: This study provides Class II evidence that ATRA improves nerve conduction in patients with chemotherapy-induced peripheral neuropathy.

more studies >>

Clinical Trials Related to Retin-A (Tretinoin Topical)

Comparison of Retinol 1.0% and Tretinoin 0.02% in the Treatment of Moderate to Severe Photodamage and Wrinkles [Recruiting]
The purpose of this study is to assess the comparative efficacy of retinol 1. 0% and tretinoin 0. 02% in minimizing wrinkles, discoloration, roughness, and other signs of moderate to severe photodamage. Our hypothesis is that both products will be of comparable benefit.

Atralin Gel for the Treatment of Rosacea [Recruiting]
Erythematotelangiectatic rosacea is a type of rosacea that causes a red face often with frequent flushing, topical sensitivity and prominent blood vessels. We think that long term damage to skin from the sun (photodamage) may play a role in causing this type of rosacea. Tretinoin is a topical medication that is known to improve photodamage. We want to find out if Atralin (tretinoin 0. 05%) Gel used for up to 46 weeks will improve erythematotelangiectatic rosacea (ETR).

Prevention of Drug Rash From Certain Cancer Therapies Using Tretinoin Cream [Recruiting]
This research is being done to study whether using of topical tretinoin can help prevent the common rash that patients often get while taking epidermal growth factor inhibitor (EGFR-I) medications such ascetuximab or erlotinib.

Patients taking EGFR-I medications often develop skin irritation and acne-like bumps on their face, chest, and other areas. This rash from EGFR-I's is often treated with moisturizers and topical or oral antibiotics. However, there has not yet been a study looking at a way to prevent this common side effect from occurring, and topical tretinoin may be useful in reducing the rash.

Tretinoin 0. 025% cream is approved by the Food and Drug Administration (FDA) for the treatment of acne, acne scarring, and photodamage. It is not approved for use in preventing rashes associated with EGFR-I's.

Combination Therapy in Amyotrophic Lateral Sclerosis (ALS) [Recruiting]
The purpose of the study is to determine the safety and the efficacy of Tretinoin and Pioglitazone HCL in patients with ALS who are currently on Riluzole.

Decitabine and Tretinoin in Treating Patients With Myelodysplastic Syndromes [Recruiting]
RATIONALE: Drugs used in chemotherapy, such as decitabine, work in different ways to stop the growth of myelodysplastic cells, either by killing the cells or by stopping them from dividing. Tretinoin and decitabine may help myelodysplastic cells become more like normal cells, and to grow and spread more slowly. Giving decitabine together with tretinoin may be an effective treatment for myelodysplastic syndromes.

PURPOSE: This phase I/II trial is studying the side effects and best dose of tretinoin when given together with decitabine in treating patients with myelodysplastic syndromes.

more trials >>


Based on a total of 55 ratings/reviews, Retin-A has an overall score of 7.55. The effectiveness score is 7.53 and the side effect score is 7.31. The scores are on ten point scale: 10 - best, 1 - worst. Below are selected reviews: the highest, the median and the lowest rated.

Retin-A review by 24 year old female patient

Overall rating:  
Effectiveness:   Highly Effective
Side effects:   Mild Side Effects
Treatment Info
Condition / reason:   minor acne
Dosage & duration:   .01 (dosage frequency: every day) for the period of a year
Other conditions:   dry skin
Other drugs taken:   none
Reported Results
Benefits:   My skin stopped breaking out as often and became much softer and smoother. The color really improved as well - much less blotchy and more "dewy."
Side effects:   Very dry skin. A lot of peeling.
Comments:   After washing my face with a gentle cleanser, I would wait 20 minutes and then put on the cream. I would then wait another 20 minutes and put some lotion on because the tretnoin was just too drying.


Retin-A review by 28 year old male patient

Overall rating:  
Effectiveness:   Moderately Effective
Side effects:   Moderate Side Effects
Treatment Info
Condition / reason:   Acne
Dosage & duration:   0.01% (dosage frequency: once a day) for the period of 2 years
Other conditions:   none
Other drugs taken:   none
Reported Results
Benefits:   Reduced acne. I had mild/moderate acne, and Retin-A did decrease the amount of ance I had. I liked Retin-A also because it reduces wrinkles. I am only 28, so I don't have many wrinkles, but used it as prevention.
Side effects:   My skin would become too dry. It seemed that even after months of usage, my ance would not completely disappear. If I used more Retin-A, my acne would get better for a week or two until my skin became too dry and then I would have worse acne
Comments:   I would apply Retin-A to my face once a day at night


Retin-A review by 16 year old female patient

Overall rating:  
Effectiveness:   Marginally Effective
Side effects:   Mild Side Effects
Treatment Info
Condition / reason:   Acne
Dosage & duration:   Do not remember (dosage frequency: applied once a day) for the period of 3 months
Other conditions:   Acne only
Other drugs taken:   Antibiotics for acne
Reported Results
Benefits:   Occasionally, acne would subside slightly.
Side effects:   Excessively dry skin and irritation
Comments:   I was to apply the Retin-A cream twice a day but the side effects outweighed any effects of treatment.

See all Retin-A reviews / ratings >>

Page last updated: 2014-11-30

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