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Retin-A Micro (Tretinoin Topical) - Summary

 
 



RETIN-A MICRO SUMMARY

Retin-A Micro (tretinoin gel) microsphere, 0.1% and 0.04%, is a formulation containing 0.1% or 0.04%, by weight, tretinoin for topical treatment of acne vulgaris. This formulation uses patented methyl methacrylate/glycol dimethacrylate crosspolymer porous microspheres (MICROSPONGE® System) to enable inclusion of the active ingredient, tretinoin, in an aqueous gel. Other components of this formulation are purified water, carbomer 974P (0.04% formulation), carbomer 934P (0.1% formulation), glycerin, disodium EDTA, propylene glycol, sorbic acid, PPG-20 methyl glucose ether distearate, cyclomethicone and dimethicone copolyol, benzyl alcohol, trolamine, and butylated hydroxytoluene.

Retin-A Micro (tretinoin gel) microsphere, 0.1% and 0.04%, is indicated for topical application in the treatment of acne vulgaris. The safety and efficacy of the use of this product in the treatment of other disorders have not been established.


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NEWS HIGHLIGHTS

Media Articles Related to Retin-A Micro (Tretinoin Topical)

Spironolactone: The 'Other' Hormonal Acne Therapy
Source: MedPageToday.com - medical news plus CME for physicians [2015.08.28]
(MedPage Today) -- Expert: drug is effective and its safety issues can be managed

Acne Pictures Slideshow: Quick Cover-ups, Do's and Don'ts
Source: MedicineNet Acne Specialty [2015.08.14]
Title: Acne Pictures Slideshow: Quick Cover-ups, Do's and Don'ts
Category: Slideshows
Created: 8/1/2012 12:00:00 AM
Last Editorial Review: 8/14/2015 12:00:00 AM

Experimental Treatment Uses Nitric Oxide for Acne
Source: MedicineNet Acne Specialty [2015.08.03]
Title: Experimental Treatment Uses Nitric Oxide for Acne
Category: Health News
Created: 7/31/2015 12:00:00 AM
Last Editorial Review: 8/3/2015 12:00:00 AM

Could a Vitamin Play a Role in Acne Outbreaks?
Source: MedicineNet Acne Specialty [2015.06.25]
Title: Could a Vitamin Play a Role in Acne Outbreaks?
Category: Health News
Created: 6/24/2015 12:00:00 AM
Last Editorial Review: 6/25/2015 12:00:00 AM

Acne patients: 'substantial proportion' fail to collect prescribed treatment
Source: Compliance News From Medical News Today [2015.03.22]
Dermatologist-prescribed treatments are being left on pharmacy shelves by up to a quarter of people with acne, according to a new study.

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Published Studies Related to Retin-A Micro (Tretinoin Topical)

Effect of Aloe vera topical gel combined with tretinoin in treatment of mild and moderate acne vulgaris: a randomized, double-blind, prospective trial. [2014]
CONCLUSION: The combination TR/AVG was well tolerated and significantly more

Tretinoin cyclodextrin complex (RA/CyD) causes less irritation with an equal antiwrinkle effect compared with conventional tretinoin: clinical and histologic studies of photoaged skin. [2012]
the side effects compared with RA treatment alone... CONCLUSION: The findings show that RA and RA/CyD result in the equivalent

A randomized, double-blind, placebo-controlled, pilot study to assess the efficacy and safety of clindamycin 1.2% and tretinoin 0.025% combination gel for the treatment of acne rosacea over 12 weeks. [2012]
rosacea after 12 weeks of usage... CONCLUSIONS: A combination gel of clindamycin phosphate 1.2% and tretinoin 0.025%

A randomized, double-blind, controlled comparative trial of the anti-aging properties of non-prescription tri-retinol 1.1% vs. prescription tretinoin 0.025%. [2012]
Vitamin A and its derivatives (commonly termed retinoids) are widely used in topical anti-aging products. Certain retinoids such as retinol and its esters are available without a prescription, while others such as tretinoin are available only via prescription... Subjects reported >93 percent overall satisfaction with both products at weeks 8 and 12.

Cortexolone 17alpha-propionate 1% cream, a new potent antiandrogen for topical treatment of acne vulgaris. A pilot randomized, double-blind comparative study vs. placebo and tretinoin 0.05% cream. [2011.07]
BACKGROUND: Acne vulgaris is a disorder of the pilosebaceous unit in which the androgens contribute to its onset and persistence. The use of antiandrogens is therefore potentially effective; however, antiandrogens for topical use are not available on the market. Cortexolone 17alpha-propionate (CB-03-01; Cosmo S.p.A, Lainate, Italy) is a new potent topical antiandrogen potentially useful in acne vulgaris. OBJECTIVES: To evaluate the safety and the topical efficacy of CB-03-01 1% cream in acne vulgaris as compared with placebo and with tretinoin 0.05% cream (Retin-A(R) ; Janssen-Cilag)... CONCLUSIONS: This pilot study supports the rationale for the use of topical antiandrogens in the treatment of acne vulgaris. CB-03-01 1% cream seems to fit with the profile of an ideal antiandrogen for topical use. (c) 2011 The Authors. BJD (c) 2011 British Association of Dermatologists 2011.

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Clinical Trials Related to Retin-A Micro (Tretinoin Topical)

90Y DOTA/Retinoic Acid for Neuroblastoma and Neuroendocrine Tumor (NET) [Active, not recruiting]
This study is for patients with neuroblastoma or a neuroendocrine tumor who have not been able to have standard therapy or have failed the first-line therapy. The purpose of this study is to assess the safety and effectiveness of the combination of retinoic acid and Onalta (Y-90-DOTA-tyr3-Octreotide) in treating neuroblastoma and neuroendocrine tumors.

Comparison of Retinol 1.0% and Tretinoin 0.02% in the Treatment of Moderate to Severe Photodamage and Wrinkles [Completed]
The purpose of this study is to assess the comparative efficacy of retinol 1. 0% and tretinoin 0. 02% in minimizing wrinkles, discoloration, roughness, and other signs of moderate to severe photodamage. Our hypothesis is that both products will be of comparable benefit.

Safety and Tolerability of Acanya Gel in Combination With Atralin Gel for Acne Vulgaris [Active, not recruiting]
The purpose of this study is to evaluate whether Cerave lotion followed by Acanya Gel in the morning in combination with Cerave lotion followed by Atralin gel in the evening is safe and effective for the treatment of acne vulgaris.

Lithium Carbonate and Tretinoin in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia [Recruiting]
This phase I trial studies the side effects and best dose of tretinoin when given together with lithium carbonate in treating patients with relapsed or refractory acute myeloid leukemia. Lithium carbonate may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Tretinoin may help [type of cancer] cells become more like normal cells, and to grow and spread more slowly. Giving lithium carbonate together with tretinoin may kill more cancer cells

Bioequivalence Study of Generic Tretinoin 0.1% Microsphere Gel, 0.1% Retin-A Micro� and Placebo [Completed]
The objective will be to assess clinical bioequivalence of 0. 1% Retin-A Micro® Gel and Spear Pharmaceutical's generic 0. 1% Tretinoin Microsphere Gel with a placebo arm.

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Reports of Suspected Retin-A Micro (Tretinoin Topical) Side Effects

Protein Urine Present (5)Albumin Urine Present (5)Headache (4)Dizziness (4)Drug Ineffective (1)Skin Exfoliation (1)Product Quality Issue (1)Crohn's Disease (1)Condition Aggravated (1)


PATIENT REVIEWS / RATINGS / COMMENTS

Based on a total of 30 ratings/reviews, Retin-A Micro has an overall score of 7.57. The effectiveness score is 7.80 and the side effect score is 7.20. The scores are on ten point scale: 10 - best, 1 - worst. Below are selected reviews: the highest, the median and the lowest rated.
 

Retin-A Micro review by 48 year old female patient

  Rating
Overall rating:  
Effectiveness:   Highly Effective
Side effects:   Mild Side Effects
  
Treatment Info
Condition / reason:   blackheads,large pores,sun damage
Dosage & duration:   0.1% (dosage frequency: every other night) for the period of 1 year
Other conditions:   fine lines
Other drugs taken:   claritin
  
Reported Results
Benefits:   I saw measurable difference in reduction of blackheads and pore size. I was also really happy with the evening of pigmentation. I had sun and age spots as well as freckling and saw a huge difference in the lightening of all these problems. My skin had a much better over all tone a seemed to become firmer over time.
Side effects:   The first few weeks of treatment my skin was peeling a little and I had some red splotches but eventually these symptoms went away.
Comments:   I would wash my face in the evening with a mild cleanser and then every other night when my face was completely dry I would apply a small amount of Retin-A to my face with the exception of the immediate eye area. The evenings that I did not use Retin-A I would use a good night moisturizer.

 

Retin-A Micro review by 29 year old female patient

  Rating
Overall rating:  
Effectiveness:   Moderately Effective
Side effects:   Moderate Side Effects
  
Treatment Info
Condition / reason:   Anti-aging, Acne
Dosage & duration:   .04% (dosage frequency: daily) for the period of 6 months
Other conditions:   None
Other drugs taken:   Nuvaring
  
Reported Results
Benefits:   The treatment benefits included Skin Regeneration, and decreased Acne. My skin felt more smooth and the pigmentation was disapearing. Overall, the goals were accomplished however the redness of the skin took over.
Side effects:   The side effects of the treatment included Redness, Dryness, Skin Irritation. The skin was very dry and difficult to moisturize. The skin looked red and irritated. However, when I switched to a lighter skin cleanser, Cetaphil, this really helped improve the redness and dryness. Prior to the Cetaphil i was using Roc cleansing pads which were too harsh on my skin.
Comments:   My routine included Daily use of Micro Retin A pump. I applied the Retin A Micro pump to my entire face at night after washing my face. I used a moisturizer and sun screen in the morning.

 

Retin-A Micro review by 25 year old female patient

  Rating
Overall rating:  
Effectiveness:   Ineffective
Side effects:   Severe Side Effects
  
Treatment Info
Condition / reason:   Acne
Dosage & duration:   0.1% (dosage frequency: every night before bedtime) for the period of 3 months
Other conditions:   None
Other drugs taken:   None
  
Reported Results
Benefits:   None at all; my acne went from mild to severe. I woke up everyday with big new, painful whiteheads. Each time a group of pimples went away, several new ones formed immediately. I also have oily skin, and I read that Retin-A rapidly reduces oil; my skin is just as oily as the day I started and my acne is as bad as when I was a teenager.
Side effects:   My skin has been extremely red the entire time I've taken this medication. It is so drying that even my ears and lips are persistently dry. I need to wear chap stick all day, everyday just to keep my lips from peeling. The area where I most use the cream has also been extremely dry and flaky.
Comments:   I applied it every night before bedtime.

See all Retin-A Micro reviews / ratings >>

Page last updated: 2015-08-28

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