RETIN-A MICRO SUMMARY
RETIN-A MICRO® (tretinoin gel) microsphere, 0.1% and 0.04%
Retin-A Micro (tretinoin gel) microsphere, 0.1% and 0.04%, is a formulation containing 0.1% or 0.04%, by weight, tretinoin for topical treatment of acne vulgaris. This formulation uses patented methyl methacrylate/glycol dimethacrylate crosspolymer porous microspheres (MICROSPONGE® System) to enable inclusion of the active ingredient, tretinoin, in an aqueous gel. Other components of this formulation are purified water, carbomer 974P (0.04% formulation), carbomer 934P (0.1% formulation), glycerin, disodium EDTA, propylene glycol, sorbic acid, PPG-20 methyl glucose ether distearate, cyclomethicone and dimethicone copolyol, benzyl alcohol, trolamine, and butylated hydroxytoluene.
Retin-A Micro (tretinoin gel) microsphere, 0.1% and 0.04%, is indicated for topical application in the treatment of acne vulgaris. The safety and efficacy of the use of this product in the treatment of other disorders have not been established.
Media Articles Related to Retin-A Micro (Tretinoin Topical)
Some acne products can cause serious allergic reactions, FDA warns
Source: Dermatology News From Medical News Today [2014.06.27]
Over the counter skin products for acne that contain benzoyl peroxide or salicylic acid can cause rare but serious and potentially life-threatening reactions, say FDA.
Some Acne Products Can Trigger Severe Allergic Reactions: FDA
Source: MedicineNet Acne Specialty [2014.06.26]
Title: Some Acne Products Can Trigger Severe Allergic Reactions: FDA
Category: Health News
Created: 6/25/2014 4:35:00 PM
Last Editorial Review: 6/26/2014 12:00:00 AM
New Approaches to Acne Treatment
Source: MedicineNet Acne Specialty [2014.06.10]
Title: New Approaches to Acne Treatment
Category: Health News
Created: 6/9/2014 12:35:00 PM
Last Editorial Review: 6/10/2014 12:00:00 AM
Clear Skin Pictures Slideshow: Helping Your Teen With Acne
Source: MedicineNet Boils Specialty [2013.11.07]
Title: Clear Skin Pictures Slideshow: Helping Your Teen With Acne
Created: 1/20/2010 3:54:00 PM
Last Editorial Review: 11/7/2013 12:00:00 AM
Source: MedicineNet Boils Specialty [2013.08.13]
Title: Acne (Pimples)
Category: Diseases and Conditions
Created: 12/31/1997 12:00:00 AM
Last Editorial Review: 8/13/2013 12:00:00 AM
Published Studies Related to Retin-A Micro (Tretinoin Topical)
Tretinoin cyclodextrin complex (RA/CyD) causes less irritation with an equal
antiwrinkle effect compared with conventional tretinoin: clinical and histologic
studies of photoaged skin. 
the side effects compared with RA treatment alone... CONCLUSION: The findings show that RA and RA/CyD result in the equivalent
A randomized, double-blind, placebo-controlled, pilot study to assess the
efficacy and safety of clindamycin 1.2% and tretinoin 0.025% combination gel for
the treatment of acne rosacea over 12 weeks. 
rosacea after 12 weeks of usage... CONCLUSIONS: A combination gel of clindamycin phosphate 1.2% and tretinoin 0.025%
A randomized, double-blind, controlled comparative trial of the anti-aging
properties of non-prescription tri-retinol 1.1% vs. prescription tretinoin
Vitamin A and its derivatives (commonly termed retinoids) are widely used in
topical anti-aging products. Certain retinoids such as retinol and its esters are
available without a prescription, while others such as tretinoin are available
only via prescription... Subjects reported >93 percent overall satisfaction with
both products at weeks 8 and 12.
Cortexolone 17alpha-propionate 1% cream, a new potent antiandrogen for topical treatment of acne vulgaris. A pilot randomized, double-blind comparative study vs. placebo and tretinoin 0.05% cream. [2011.07]
BACKGROUND: Acne vulgaris is a disorder of the pilosebaceous unit in which the androgens contribute to its onset and persistence. The use of antiandrogens is therefore potentially effective; however, antiandrogens for topical use are not available on the market. Cortexolone 17alpha-propionate (CB-03-01; Cosmo S.p.A, Lainate, Italy) is a new potent topical antiandrogen potentially useful in acne vulgaris. OBJECTIVES: To evaluate the safety and the topical efficacy of CB-03-01 1% cream in acne vulgaris as compared with placebo and with tretinoin 0.05% cream (Retin-A(R) ; Janssen-Cilag)... CONCLUSIONS: This pilot study supports the rationale for the use of topical antiandrogens in the treatment of acne vulgaris. CB-03-01 1% cream seems to fit with the profile of an ideal antiandrogen for topical use. (c) 2011 The Authors. BJD (c) 2011 British Association of Dermatologists 2011.
Pharmacokinetic interactions between alitretinoin and ketoconazole or simvastatin or ciclosporin A. [2011.04]
BACKGROUND: Based on in vitro data with isolated cytochrome P450 (CYP) isoenzymes, alitretinoin interacts only with CYP3A4, and the potential for drug-drug interactions is considered negligible. AIM: To confirm in humans the lack of potential interactions between CYP3A4 and alitretinoin in vivo... CONCLUSIONS: Single and repeated doses of alitretinoin do not alter the PK of ciclosporin A and ketoconazole. Simvastatin levels were slightly but significantly reduced by co-administration of alitretinoin. Substrates of CYP3A4 did not affect the PK of alitretinoin. However, ketoconazole significantly increased the plasma levels of alitretinoin, therefore, co-administration with CYP3A4 inhibitors such as ketoconazole may require a dose reduction of alitretinoin. (c) 2011 The Author(s). Clinical and Experimental Dermatology (c) 2011 British Association of Dermatologists.
Clinical Trials Related to Retin-A Micro (Tretinoin Topical)
Combined Tretinoin and Arsenic Trioxide for Patients With Newly Diagnosed Acute Promyelocytic Leukemia Followed by Risk-Adapted Postremission Therapy [Recruiting]
The purpose of this study is to find what effects, good and/or bad, treatment with two drugs
has on leukemia. The first medicine is tretinoin (also called all-trans retinoic acid,
ATRA, or Vesanoid). It is an approved medicine that causes the leukemia cells in APL to
mature. It is related to vitamin A. The second is arsenic trioxide (Trisenox). It is an
approved medicine for APL that comes back after earlier treatment.
APL is most often treated with tretinoin and standard chemotherapy drugs. These
chemotherapy drugs can cause infection and bleeding. They can also damage the heart and
normal bone marrow cells. This can lead to a second leukemia years later.
In this study, the investigators are using tretinoin and arsenic trioxide together. Both
drugs work to treat APL. They have been used together in only a limited number of people.
The investigators want to use these drugs together to reduce the amount of standard
chemotherapy and decrease side effects. The patient will receive standard chemotherapy with
a drug called idarubicin only if they have a higher chance of the leukemia coming back or a
higher risk of side effects.
Comparison of Retinol 1.0% and Tretinoin 0.02% in the Treatment of Moderate to Severe Photodamage and Wrinkles [Recruiting]
The purpose of this study is to assess the comparative efficacy of retinol 1. 0% and
tretinoin 0. 02% in minimizing wrinkles, discoloration, roughness, and other signs of
moderate to severe photodamage. Our hypothesis is that both products will be of comparable
A Study Comparing Combination Clindamycin Phosphate/Tretinoin Gel Alone Versus With Benzoyl Peroxide Foaming Cloths for Facial Acne [Recruiting]
There are many different factors that cause acne. So combination treatment using different
medications that can address these different factors is commonly used to treat acne.
Fixed-dose combination clindamycin phosphate 1. 2% and tretinoin 0. 025% gel and benzoyl
peroxide 6% foaming cloths are both used to treat acne. This study will evaluate the use of
the medications when used together.
A Comparative Study of Adapalene Gel,0.3% Versus Tretinoin Emollient Cream, 0.05% for the Treatment of Photoaging [Recruiting]
The purpose of this study is to:
1. Evaluate the efficacy of Adapalene gel 0. 3% compared to Tretinoin Emollient cream
0. 05%, reducing signs of cutaneous photoageing, measured trough photonumeric scale
evaluation, investigator evaluation of global response to treatment and subject's
evaluation of improvement.
2. Evaluate the safety and tolerability of Adapalene Gel 0. 3%, compared to Tretinoin
Emollient cream 0. 05% during 24 weeks of treatment.
The study has the clinical hypothesis that Adapalene Gel 0. 3% is as effective as Tretinoin
Emollient cream 0. 05% in the treatment of cutaneous photoaging.
Atralin Gel for the Treatment of Rosacea [Recruiting]
Erythematotelangiectatic rosacea is a type of rosacea that causes a red face often with
frequent flushing, topical sensitivity and prominent blood vessels. We think that long term
damage to skin from the sun (photodamage) may play a role in causing this type of rosacea.
Tretinoin is a topical medication that is known to improve photodamage. We want to find out
if Atralin (tretinoin 0. 05%) Gel used for up to 46 weeks will improve
erythematotelangiectatic rosacea (ETR).
Reports of Suspected Retin-A Micro (Tretinoin Topical) Side Effects
Protein Urine Present (5),
Albumin Urine Present (5),
Drug Ineffective (1),
Skin Exfoliation (1),
Product Quality Issue (1),
Crohn's Disease (1),
Condition Aggravated (1)
PATIENT REVIEWS / RATINGS / COMMENTS
Based on a total of 30 ratings/reviews, Retin-A Micro has an overall score of 7.57. The effectiveness score is 7.80 and the side effect score is 7.20. The scores are on ten point scale: 10 - best, 1 - worst. Below are selected reviews: the highest, the median and the lowest rated.
Retin-A Micro review by 48 year old female patient
|Overall rating:|| || |
|Effectiveness:|| || Highly Effective|
|Side effects:|| || Mild Side Effects|
|Condition / reason:|| || blackheads,large pores,sun damage|
|Dosage & duration:|| || 0.1% (dosage frequency: every other night) for the period of 1 year|
|Other conditions:|| || fine lines|
|Other drugs taken:|| || claritin|
|Benefits:|| || I saw measurable difference in reduction of blackheads and pore size. I was also really happy with the evening of pigmentation. I had sun and age spots as well as freckling and saw a huge difference in the lightening of all these problems. My skin had a much better over all tone a seemed to become firmer over time.|
|Side effects:|| || The first few weeks of treatment my skin was peeling a little and I had some red splotches but eventually these symptoms went away. |
|Comments:|| || I would wash my face in the evening with a mild cleanser and then every other night when my face was completely dry I would apply a small amount of Retin-A to my face with the exception of the immediate eye area. The evenings that I did not use Retin-A I would use a good night moisturizer.|
Retin-A Micro review by 29 year old female patient
|Overall rating:|| || |
|Effectiveness:|| || Moderately Effective|
|Side effects:|| || Moderate Side Effects|
|Condition / reason:|| || Anti-aging, Acne|
|Dosage & duration:|| || .04% (dosage frequency: daily) for the period of 6 months|
|Other conditions:|| || None|
|Other drugs taken:|| || Nuvaring|
|Benefits:|| || The treatment benefits included Skin Regeneration, and decreased Acne. My skin felt more smooth and the pigmentation was disapearing. Overall, the goals were accomplished however the redness of the skin took over.|
|Side effects:|| || The side effects of the treatment included Redness, Dryness, Skin Irritation. The skin was very dry and difficult to moisturize. The skin looked red and irritated. However, when I switched to a lighter skin cleanser, Cetaphil, this really helped improve the redness and dryness. Prior to the Cetaphil i was using Roc cleansing pads which were too harsh on my skin.|
|Comments:|| || My routine included Daily use of Micro Retin A pump. I applied the Retin A Micro pump to my entire face at night after washing my face. I used a moisturizer and sun screen in the morning.|
Retin-A Micro review by 25 year old female patient
|Overall rating:|| || |
|Effectiveness:|| || Ineffective|
|Side effects:|| || Severe Side Effects|
|Condition / reason:|| || Acne|
|Dosage & duration:|| || 0.1% (dosage frequency: every night before bedtime) for the period of 3 months|
|Other conditions:|| || None|
|Other drugs taken:|| || None|
|Benefits:|| || None at all; my acne went from mild to severe. I woke up everyday with big new, painful whiteheads. Each time a group of pimples went away, several new ones formed immediately. I also have oily skin, and I read that Retin-A rapidly reduces oil; my skin is just as oily as the day I started and my acne is as bad as when I was a teenager.|
|Side effects:|| || My skin has been extremely red the entire time I've taken this medication. It is so drying that even my ears and lips are persistently dry. I need to wear chap stick all day, everyday just to keep my lips from peeling. The area where I most use the cream has also been extremely dry and flaky.|
|Comments:|| || I applied it every night before bedtime.|
Page last updated: 2014-06-27