RETIN-A MICRO SUMMARY
RETIN-A MICRO® (tretinoin gel) microsphere, 0.1% and 0.04%
Retin-A Micro (tretinoin gel) microsphere, 0.1% and 0.04%, is a formulation containing 0.1% or 0.04%, by weight, tretinoin for topical treatment of acne vulgaris. This formulation uses patented methyl methacrylate/glycol dimethacrylate crosspolymer porous microspheres (MICROSPONGE® System) to enable inclusion of the active ingredient, tretinoin, in an aqueous gel. Other components of this formulation are purified water, carbomer 974P (0.04% formulation), carbomer 934P (0.1% formulation), glycerin, disodium EDTA, propylene glycol, sorbic acid, PPG-20 methyl glucose ether distearate, cyclomethicone and dimethicone copolyol, benzyl alcohol, trolamine, and butylated hydroxytoluene.
Retin-A Micro (tretinoin gel) microsphere, 0.1% and 0.04%, is indicated for topical application in the treatment of acne vulgaris. The safety and efficacy of the use of this product in the treatment of other disorders have not been established.
Media Articles Related to Retin-A Micro (Tretinoin Topical)
Galderma receives FDA approval for new antibiotic-free treatment option for acne patients
Source: Dermatology News From Medical News Today [2015.07.20]
Galderma Laboratories, L.P. has announced that the U.S. Food and Drug Administration (FDA) approved antibiotic-free Epiduo® Forte (adapalene and benzoyl peroxide) Gel, 0.3%/2.
Nanoparticles used to prevent inflammatory acne through slow-released nitric oxide
Source: Dermatology News From Medical News Today [2015.07.16]
GW researcher and dermatologist, Adam Friedman, M.D., and colleagues, find that the release of nitric oxide over time may be a new way to treat and prevent acne through nanotechnology.
Acne Pictures Slideshow: Quick Cover-ups, Do's and Don'ts
Source: MedicineNet Acne Specialty [2015.06.26]
Title: Acne Pictures Slideshow: Quick Cover-ups, Do's and Don'ts
Created: 8/1/2012 12:00:00 AM
Last Editorial Review: 6/26/2015 12:00:00 AM
Could a Vitamin Play a Role in Acne Outbreaks?
Source: MedicineNet Acne Specialty [2015.06.25]
Title: Could a Vitamin Play a Role in Acne Outbreaks?
Category: Health News
Created: 6/24/2015 12:00:00 AM
Last Editorial Review: 6/25/2015 12:00:00 AM
Acne patients: 'substantial proportion' fail to collect prescribed treatment
Source: Compliance News From Medical News Today [2015.03.22]
Dermatologist-prescribed treatments are being left on pharmacy shelves by up to a quarter of people with acne, according to a new study.
Published Studies Related to Retin-A Micro (Tretinoin Topical)
Effect of Aloe vera topical gel combined with tretinoin in treatment of mild and
moderate acne vulgaris: a randomized, double-blind, prospective trial. 
CONCLUSION: The combination TR/AVG was well tolerated and significantly more
Tretinoin cyclodextrin complex (RA/CyD) causes less irritation with an equal
antiwrinkle effect compared with conventional tretinoin: clinical and histologic
studies of photoaged skin. 
the side effects compared with RA treatment alone... CONCLUSION: The findings show that RA and RA/CyD result in the equivalent
A randomized, double-blind, placebo-controlled, pilot study to assess the
efficacy and safety of clindamycin 1.2% and tretinoin 0.025% combination gel for
the treatment of acne rosacea over 12 weeks. 
rosacea after 12 weeks of usage... CONCLUSIONS: A combination gel of clindamycin phosphate 1.2% and tretinoin 0.025%
A randomized, double-blind, controlled comparative trial of the anti-aging
properties of non-prescription tri-retinol 1.1% vs. prescription tretinoin
Vitamin A and its derivatives (commonly termed retinoids) are widely used in
topical anti-aging products. Certain retinoids such as retinol and its esters are
available without a prescription, while others such as tretinoin are available
only via prescription... Subjects reported >93 percent overall satisfaction with
both products at weeks 8 and 12.
Cortexolone 17alpha-propionate 1% cream, a new potent antiandrogen for topical treatment of acne vulgaris. A pilot randomized, double-blind comparative study vs. placebo and tretinoin 0.05% cream. [2011.07]
BACKGROUND: Acne vulgaris is a disorder of the pilosebaceous unit in which the androgens contribute to its onset and persistence. The use of antiandrogens is therefore potentially effective; however, antiandrogens for topical use are not available on the market. Cortexolone 17alpha-propionate (CB-03-01; Cosmo S.p.A, Lainate, Italy) is a new potent topical antiandrogen potentially useful in acne vulgaris. OBJECTIVES: To evaluate the safety and the topical efficacy of CB-03-01 1% cream in acne vulgaris as compared with placebo and with tretinoin 0.05% cream (Retin-A(R) ; Janssen-Cilag)... CONCLUSIONS: This pilot study supports the rationale for the use of topical antiandrogens in the treatment of acne vulgaris. CB-03-01 1% cream seems to fit with the profile of an ideal antiandrogen for topical use. (c) 2011 The Authors. BJD (c) 2011 British Association of Dermatologists 2011.
Clinical Trials Related to Retin-A Micro (Tretinoin Topical)
Comparison of Retinol 1.0% and Tretinoin 0.02% in the Treatment of Moderate to Severe Photodamage and Wrinkles [Recruiting]
The purpose of this study is to assess the comparative efficacy of retinol 1. 0% and
tretinoin 0. 02% in minimizing wrinkles, discoloration, roughness, and other signs of
moderate to severe photodamage. Our hypothesis is that both products will be of comparable
Atralin Gel for the Treatment of Rosacea [Recruiting]
Erythematotelangiectatic rosacea is a type of rosacea that causes a red face often with
frequent flushing, topical sensitivity and prominent blood vessels. We think that long term
damage to skin from the sun (photodamage) may play a role in causing this type of rosacea.
Tretinoin is a topical medication that is known to improve photodamage. We want to find out
if Atralin (tretinoin 0. 05%) Gel used for up to 46 weeks will improve
erythematotelangiectatic rosacea (ETR).
Prevention of Drug Rash From Certain Cancer Therapies Using Tretinoin Cream [Recruiting]
This research is being done to study whether using of topical tretinoin can help prevent the
common rash that patients often get while taking epidermal growth factor inhibitor (EGFR-I)
medications such ascetuximab or erlotinib.
Patients taking EGFR-I medications often develop skin irritation and acne-like bumps on
their face, chest, and other areas. This rash from EGFR-I's is often treated with
moisturizers and topical or oral antibiotics. However, there has not yet been a study
looking at a way to prevent this common side effect from occurring, and topical tretinoin
may be useful in reducing the rash.
Tretinoin 0. 025% cream is approved by the Food and Drug Administration (FDA) for the
treatment of acne, acne scarring, and photodamage. It is not approved for use in preventing
rashes associated with EGFR-I's.
Efficiency And Safety Of Association Arbutin, Triamcinolone And Tretinoin In Treatment Of Melasma [Not yet recruiting]
Combination Therapy in Amyotrophic Lateral Sclerosis (ALS) [Recruiting]
The purpose of the study is to determine the safety and the efficacy of Tretinoin and
Pioglitazone HCL in patients with ALS who are currently on Riluzole.
Reports of Suspected Retin-A Micro (Tretinoin Topical) Side Effects
Protein Urine Present (5),
Albumin Urine Present (5),
Drug Ineffective (1),
Skin Exfoliation (1),
Product Quality Issue (1),
Crohn's Disease (1),
Condition Aggravated (1)
PATIENT REVIEWS / RATINGS / COMMENTS
Based on a total of 30 ratings/reviews, Retin-A Micro has an overall score of 7.57. The effectiveness score is 7.80 and the side effect score is 7.20. The scores are on ten point scale: 10 - best, 1 - worst. Below are selected reviews: the highest, the median and the lowest rated.
Retin-A Micro review by 48 year old female patient
|Overall rating:|| || |
|Effectiveness:|| || Highly Effective|
|Side effects:|| || Mild Side Effects|
|Condition / reason:|| || blackheads,large pores,sun damage|
|Dosage & duration:|| || 0.1% (dosage frequency: every other night) for the period of 1 year|
|Other conditions:|| || fine lines|
|Other drugs taken:|| || claritin|
|Benefits:|| || I saw measurable difference in reduction of blackheads and pore size. I was also really happy with the evening of pigmentation. I had sun and age spots as well as freckling and saw a huge difference in the lightening of all these problems. My skin had a much better over all tone a seemed to become firmer over time.|
|Side effects:|| || The first few weeks of treatment my skin was peeling a little and I had some red splotches but eventually these symptoms went away. |
|Comments:|| || I would wash my face in the evening with a mild cleanser and then every other night when my face was completely dry I would apply a small amount of Retin-A to my face with the exception of the immediate eye area. The evenings that I did not use Retin-A I would use a good night moisturizer.|
Retin-A Micro review by 29 year old female patient
|Overall rating:|| || |
|Effectiveness:|| || Moderately Effective|
|Side effects:|| || Moderate Side Effects|
|Condition / reason:|| || Anti-aging, Acne|
|Dosage & duration:|| || .04% (dosage frequency: daily) for the period of 6 months|
|Other conditions:|| || None|
|Other drugs taken:|| || Nuvaring|
|Benefits:|| || The treatment benefits included Skin Regeneration, and decreased Acne. My skin felt more smooth and the pigmentation was disapearing. Overall, the goals were accomplished however the redness of the skin took over.|
|Side effects:|| || The side effects of the treatment included Redness, Dryness, Skin Irritation. The skin was very dry and difficult to moisturize. The skin looked red and irritated. However, when I switched to a lighter skin cleanser, Cetaphil, this really helped improve the redness and dryness. Prior to the Cetaphil i was using Roc cleansing pads which were too harsh on my skin.|
|Comments:|| || My routine included Daily use of Micro Retin A pump. I applied the Retin A Micro pump to my entire face at night after washing my face. I used a moisturizer and sun screen in the morning.|
Retin-A Micro review by 25 year old female patient
|Overall rating:|| || |
|Effectiveness:|| || Ineffective|
|Side effects:|| || Severe Side Effects|
|Condition / reason:|| || Acne|
|Dosage & duration:|| || 0.1% (dosage frequency: every night before bedtime) for the period of 3 months|
|Other conditions:|| || None|
|Other drugs taken:|| || None|
|Benefits:|| || None at all; my acne went from mild to severe. I woke up everyday with big new, painful whiteheads. Each time a group of pimples went away, several new ones formed immediately. I also have oily skin, and I read that Retin-A rapidly reduces oil; my skin is just as oily as the day I started and my acne is as bad as when I was a teenager.|
|Side effects:|| || My skin has been extremely red the entire time I've taken this medication. It is so drying that even my ears and lips are persistently dry. I need to wear chap stick all day, everyday just to keep my lips from peeling. The area where I most use the cream has also been extremely dry and flaky.|
|Comments:|| || I applied it every night before bedtime.|
Page last updated: 2015-07-20