Media Articles Related to Rescriptor (Delavirdine)
Four simultaneous interventions could lead to a 62 percent decrease in new HIV infections by 2040
Source: Alcohol / Addiction / Illegal Drugs News From Medical News Today [2014.03.06]
A computer model has created the most effective formula for reducing the spread of HIV among drug users in New York City over the next 25 years.
How sexual contacts with outsiders contribute to HIV infections within communities
Source: HIV / AIDS News From Medical News Today [2014.03.05]
While a number of strategies can prevent and control HIV transmission and spread, their effective use depends on understanding the sexual networks within and between communities. A paper published in PLOS Medicine reports a detailed analysis with surprising results from the Rakai district in Uganda, one of the most studied areas of the HIV/AIDS epidemic in Africa. Mary K.
During pregnancy and the postpartum period women at greater risk of HIV infection
Source: HIV / AIDS News From Medical News Today [2014.02.27]
Women living in world regions where HIV infection is common are at high risk of acquiring HIV infection during pregnancy and the postpartum period, according to a study by US researchers published in this week's PLOS Medicine.
Baby "Cured" of HIV Infection
Source: MedicineNet nevirapine Specialty [2013.04.03]
Title: Baby "Cured" of HIV Infection
Category: Doctor's & Expert's views on Symptoms
Created: 4/3/2013 6:12:00 PM
Last Editorial Review: 4/3/2013 6:12:53 PM
New research on potent HIV antibodies opens up possibilities for HIV prevention and treatment
Source: HIV / AIDS News From Medical News Today [2014.03.05]
The discovery of how a KwaZulu-Natal woman's body responded to her HIV infection by making potent antibodies (called broadly neutralising antibodies, because they are able to kill multiple strains of HIV from across the world), was reported today (3 March 2014) by the CAPRISA consortium of AIDS researchers jointly with scientists from the United States.
Published Studies Related to Rescriptor (Delavirdine)
Population pharmacokinetics of delavirdine and N-delavirdine in HIV-infected individuals. 
OBJECTIVE: Delavirdine is a non-nucleoside reverse transcriptase inhibitor used in combination regimens for the treatment of HIV-1 infection. Our objective was to characterise the population pharmacokinetics of delavirdine in HIV-infected patients who participated in the adult AIDS Clinical Trials Group (ACTG) 260 and 261 studies... CONCLUSIONS: Delavirdine disposition exhibits nonlinear pharmacokinetics and large interpatient variability, and is significantly altered by time of day (impacting potential therapeutic drug monitoring and future pharmacokinetic study designs). Although race and sex appear to influence delavirdine pharmacokinetics, men and women and patients of different races should receive similar mg/kg dosage regimens. The presence of large interpatient variability supports the further investigation of the utility of therapeutic drug monitoring for delavirdine, if target drug concentrations can be better defined.
Delavirdine malabsorption in HIV-infected subjects with spontaneous gastric hypoacidity. [2003.02]
To determine the impact of gastric hypoacidity and acidic beverages on delavirdine mesylate pharmacokinetics in HIV-infected subjects, matched subjects with (n = 11) and without (n = 10) gastric hypoacidity received delavirdine 400 mg tid with either water or an acidic beverage (usually orange juice)...
Pharmacokinetic interaction between amprenavir and delavirdine after multiple-dose administration in healthy volunteers. [2003.01]
AIMS: To evaluate the safety and the pharmacokinetic interaction between amprenavir and delavirdine after multiple dose administration in healthy volunteers... CONCLUSIONS: Amprenavir is an effective inducer of delavirdine metabolism, probably through its effect on hepatic CYP3A4. This could have consequences in other drug-drug interaction situations. Delavirdine is an inhibitor of amprenavir metabolism. The regimen of amprenavir 600 mg and delavirdine 600 mg twice a day is not recommended when an antiretroviral effect from delavirdine is required.
A randomized trial of nelfinavir, ritonavir, or delavirdine in combination with saquinavir-SGC and stavudine in treatment-experienced HIV-1-infected patients. [2001.03]
CONCLUSION: The use of antiretroviral agents that pharmacokinetically boost saquinavir levels has a modest benefit in saquinavir-experienced patients.
Delavirdine in combination with zidovudine in treatment of human immunodeficiency virus type 1-infected patients: evaluation of efficacy and emergence of viral resistance in a randomized, comparative phase III trial. The M/3331/0013B Study Group. [2000.11]
We compared the activity of delavirdine (DLV) plus zidovudine (AZT) (n = 300) with that of AZT (n = 297) against human immunodeficiency virus type 1 in a randomized, double-blind, placebo-controlled trial. DLV exerted a transient antiviral effect, and mutations for resistance to DLV were found in more than 90% of subjects at week 12.
Clinical Trials Related to Rescriptor (Delavirdine)
A Study of Delavirdine Mesylate in Combination With Other Anti-HIV Drugs in HIV-Infected Children and Babies [Completed]
The purpose of this study is to see if it is safe and effective to give delavirdine mesylate
(Rescriptor) plus two nucleoside reverse transcriptase inhibitors (NRTIs) to HIV-infected
children and babies. This study also examines how the body processes Rescriptor when taken
with 2 NRTIs.
A Phase II Double-Blind Study of Delavirdine Mesylate ( U-90152 ) in Combination With Zidovudine ( AZT ) and/or Didanosine ( ddI ) Versus AZT and ddI Combination Therapy [Completed]
To determine the safety and anti-HIV activity of delavirdine mesylate ( U-90152 ) in
combination with zidovudine ( AZT ) and/or didanosine ( ddI ) versus AZT/ddI combination.
U-90152 has demonstrated anti-HIV activity. Since the combination of this drug with either
AZT or ddI has synergistic inhibitory activity against HIV-1 in vitro, and triple therapy
appears to have greater inhibitory activity against HIV-1 in vitro than dual therapy, the use
of U-90152 in combination with AZT and/or ddI may improve the benefits of these drugs in
persons with HIV disease.
A Double-Blind, Randomized, Comparative Study of Delavirdine Mesylate (U-90152S) in Combination With Didanosine (ddI) Versus ddI Alone in HIV-1 Infected Individuals With CD4 Counts of <= 300/mm3 [Completed]
To evaluate the safety, tolerance, pharmacokinetics, and efficacy of delavirdine mesylate
(U-90152S) in combination with didanosine (ddI) versus ddI alone in HIV-positive patients.
A Study of Delavirdine Used Together With Other Anti-HIV Drugs in HIV-Infected Patients [Completed]
The purpose of this study is to see if it is safe and effective to give delavirdine (DLV) in
combination with two or three other drugs to HIV-infected patients. The drugs to be used in
combination with DLV are zidovudine (ZDV), indinavir (IDV), and lamivudine (3TC).
A Double-Blind, Randomized, Dose Response Study of Three Doses of Delavirdine Mesylate (U-90152S) in Combination With Zidovudine (ZDV) Versus ZDV Alone in HIV-1 Infected Individuals With CD4 Counts of 200-500mm3 [Completed]
PART I: To evaluate the safety, tolerance, efficacy, and pharmacokinetics of three fixed
doses of delavirdine mesylate (DLV) in combination with zidovudine (AZT) versus AZT alone in
PART II: To evaluate the safety, tolerance, efficacy, and pharmacokinetics of ZDV plus 3TC
with or without DLV versus ZDV plus DLV in HIV-positive patients.