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Requip (Ropinirole Hydrochloride) - Summary



REQUIP (ropinirole) is an orally administered non-ergoline dopamine agonist.

Parkinson’s Disease

REQUIP is indicated for the treatment of the signs and symptoms of idiopathic Parkinson’s disease.

The effectiveness of REQUIP was demonstrated in randomized, controlled trials in patients with early Parkinson’s disease who were not receiving concomitant L-dopa therapy as well as in patients with advanced disease on concomitant L-dopa (see CLINICAL PHARMACOLOGY: Clinical Trials).

Restless Legs Syndrome

REQUIP is indicated for the treatment of moderate-to-severe primary Restless Legs Syndrome (RLS).

Key diagnostic criteria for RLS are: an urge to move the legs usually accompanied or caused by uncomfortable and unpleasant leg sensations; symptoms begin or worsen during periods of rest or inactivity such as lying or sitting; symptoms are partially or totally relieved by movement such as walking or stretching at least as long as the activity continues; and symptoms are worse or occur only in the evening or night. Difficulty falling asleep may frequently be associated with moderate-to-severe RLS.

See all Requip indications & dosage >>


Media Articles Related to Requip (Ropinirole)

Scientists probing molecular origins of Parkinson's disease highlight two proteins
Source: Biology / Biochemistry News From Medical News Today [2015.08.11]
Using a new approach to focus on relevant molecules, scientists discover two gene-regulating proteins that appear to protect neurons most affected by Parkinson's disease.

Promising drug for Parkinson's disease: Study supports fast track to clinical trials
Source: Liver Disease / Hepatitis News From Medical News Today [2015.08.10]
A drug which has already been in use for decades to treat liver disease could be an effective treatment to slow down progression of Parkinson's disease, scientists from the University of Sheffield...

Parkinson's Disease Quiz: Test Your Medical IQ
Source: MedicineNet amantadine Specialty [2015.02.20]
Title: Parkinson's Disease Quiz: Test Your Medical IQ
Category: MedicineNet Quiz
Created: 8/23/2011 12:53:00 PM
Last Editorial Review: 2/20/2015 4:38:06 PM

Scripps Florida scientists' 'mad cow' discovery points to possible neuron killing mechanism behind Alzheimer's and Parkinson's diseases
Source: CJD / vCJD / Mad Cow Disease News From Medical News Today [2015.02.16]
Scientists from the Florida campus of The Scripps Research Institute (TSRI) have for the first time discovered a killing mechanism that could underpin a range of the most intractable...

Parkinson's Disease
Source: MedicineNet Huntington Disease Specialty [2015.02.04]
Title: Parkinson's Disease
Category: Diseases and Conditions
Created: 12/31/1997 12:00:00 AM
Last Editorial Review: 2/4/2015 12:00:00 AM

more news >>

Published Studies Related to Requip (Ropinirole)

Rotigotine vs ropinirole in advanced stage Parkinson's disease: a double-blind study. [2014]
(PD) patients on concomitant levodopa therapy... CONCLUSIONS: Rotigotine was well tolerated at doses up to 16 mg/24 h and showed

[Efficacy and safety of ropinirole in the treatment of Parkinson's disease: a multi-center, randomized, double-blind and bromocriptine-controlled trial]. [Article in Chinese] [2013]
Parkinson's disease... CONCLUSIONS: Ropinirole is both effective and safe in the treatment of Chinese

The efficacy and safety of ropinirole prolonged release tablets as adjunctive therapy in Chinese subjects with advanced Parkinson's disease: a multicenter, double-blind, randomized, placebo-controlled study. [2013]
Parkinson's disease (PD) not optimally controlled with L-dopa... CONCLUSIONS: This study demonstrated for the first time in Chinese subjects that

PREPARED: Comparison of prolonged and immediate release ropinirole in advanced Parkinson's disease. [2011.06]
BACKGROUND: PREPARED was a randomized, parallel-group, double-blind, multicenter study to evaluate the efficacy of adjunctive ropinirole prolonged release (PR) versus immediate release (IR) in patients with advanced Parkinson's disease (PD)... CONCLUSIONS: Adjunctive PR provided a significantly greater improvement in symptom control in terms of the odds of achieving >/= 20% maintained reduction in time spent "off" compared with IR. Interpretation may be confounded by the higher doses of PR versus IR that were achieved, in combination with lower doses of L-dopa by the study end. Despite dosing differences, the PR titration regimen was generally well tolerated, with an AE profile similar to that of IR. Copyright (c) 2011 Movement Disorder Society.

Ropinirole improves depressive symptoms and restless legs syndrome severity in RLS patients: a multicentre, randomized, placebo-controlled study. [2011.06]
Comorbid depressive symptoms in restless legs syndrome (RLS) remain a treatment challenge, as some antidepressants aggravate RLS symptoms...

more studies >>

Clinical Trials Related to Requip (Ropinirole)

A Comparison of Ropinirole Immediate Release With Ropinirole Prolonged Release in Patients With Advanced Parkinson's [Completed]
This study was designed to compare the effectiveness and tolerability of a new prolonged release formulation of ropinirole with the currently marketed immediate release formulation which is prescribed in many countries. The new prolonged release formulation allows the drug to be taken once a day rather than three times a day. This study will also evaluate the side effects of the new prolonged release formulation of ropinirole

Study to Observe the Effect of Requip PD Once-daily (QD) Versus Twice-daily (BID) [Recruiting]
1. In order to observe the benefit, side effects, and patient preference of Requip PD when used in QD or BID dosing

2. In order to estimate the conversion rate of dopamine agonists into Requip PD

Converting From Ropinirole Immediate Release (IR) To Ropinirole Controlled-Release for RLS (Restless Legs Syndrome) [Completed]

Treating Sexual Dysfunction From SSRI Medication: a Study Comparing Requip CR to Placebo [Active, not recruiting]
Antidepressant medicines sometimes cause sexual side effects. The purpose of this study is to determine whether the sexual dysfunction sometimes caused by selective serotonin reuptake inhibitor (SSRI) antidepressant medications can be reversed by treatment with Requip (ropinirole), a medicine which is used to treat Parkinson's Disease and restless leg syndrome.

Long-Term Extension Study Evaluating Extended Release Ropinirole XL (Formerly Referred to as Ropinirole CR) in Patients Who Already Completed Either Study 167 or 164 [Active, not recruiting]
The purpose of this study is to obtain information on the long-term safety, tolerability, and therapeutic benefit of extended release ropinirole XL, and to provide a mechanism for patients who participated in either Study 167 or Study 164 to continue receiving ropinirole XL if they chose to do so.

more trials >>

Reports of Suspected Requip (Ropinirole) Side Effects

Drug Ineffective (46)Pathological Gambling (30)Sudden Onset of Sleep (27)Confusional State (25)Fatigue (25)Nausea (24)Somnolence (22)Insomnia (20)Dyskinesia (17)Fall (16)more >>


Based on a total of 10 ratings/reviews, Requip has an overall score of 8.20. The effectiveness score is 8.80 and the side effect score is 8. The scores are on ten point scale: 10 - best, 1 - worst. Below are selected reviews: the highest, the median and the lowest rated.

Requip review by 53 year old female patient

Overall rating:  
Effectiveness:   Highly Effective
Side effects:   Mild Side Effects
Treatment Info
Condition / reason:   Restless leg syndrome
Dosage & duration:   0.5 mg taken at bedtime for the period of 2 years
Other conditions:   Sleeplessness
Other drugs taken:   None
Reported Results
Benefits:   While standing, my legs were fine, but aching, cramping legs were keeping me from getting any sleep. My doctor suggested I try Requip, and its been the best thing I have done.
Side effects:   I have experienced no side effects, except sleeping at night. The warning says that it might make you drowsy, but that's also why they say to take it at night.
Comments:   I take Requip about 1-1/2 to 2 hours before bedtime. It permits relaxation of legs so I can sleep.


Requip review by 40 year old female patient

Overall rating:  
Effectiveness:   Highly Effective
Side effects:   No Side Effects
Treatment Info
Condition / reason:   RLS
Dosage & duration:   1 mg/day taken 1 for the period of 1 yr
Other conditions:   none
Other drugs taken:   birth control
Reported Results
Benefits:   my legs stay still so i can get to sleep and stay asleep
Side effects:   i feel nauseated about 1/2 hour after i take it
Comments:   I take 1 -1.5 mg per night about an hour before i go to bed. it stops the feeling of havingto move my legs and quiets them while i sleep so i can get sustained deep sleep.


Requip review by 63 year old female patient

Overall rating:  
Effectiveness:   Marginally Effective
Side effects:   Extremely Severe Side Effects
Treatment Info
Condition / reason:   RLS associated with sleep apnea
Dosage & duration:   3mg taken nightly for the period of 3 months
Other conditions:   diabetes
Other drugs taken:   Novalog
Reported Results
Benefits:   None
Side effects:   Began with Requip pack and gradually increased dosage. Immediately felt more lethargic and irritable. On my third week at 3mg. I could not keep any food down in the mornings. My doctor said the sleepiness and irritability was not related to Requip. After 10 days of vomiting in the a.m I stopped the medication. Feel much better even though my doctor insists I need it.
Comments:   Gradually increased dosage. After last overnight sleep study doctor increased by dosage to 3 mg. That's when the severe nausea and then followed by vomiting.

See all Requip reviews / ratings >>

Page last updated: 2015-08-11

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