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Renese-R (Polythiazide / Reserpine) - Indications and Dosage

 
 



INDICATIONS AND USAGE

Hypertension (see box warning).

Usage in Pregnancy

The routine use of diuretics in an otherwise healthy woman is inappropriate and exposes mother and fetus to unnecessary hazard. Diuretics do not prevent development of toxemia of pregnancy, and there is no satisfactory evidence that they are useful in the treatment of developed toxemia.

Edema during pregnancy may arise from pathological causes or from the physiologic and mechanical consequences of pregnancy. Thiazides are indicated in pregnancy when edema is due to pathologic causes, just as they are in the absence of pregnancy (however, see Precautions/Pregnancy section). Dependent edema in pregnancy, resulting from restriction of venous return by the expanded uterus, is properly treated through elevation of the lower extremities and use of support hose; use of diuretics to lower intravascular volume in this case is illogical and unnecessary. There is hypervolemia during normal pregnancy which is harmful to neither the fetus nor the mother (in the absence of cardiovascular disease), but which is associated with edema – including generalized edema, in the majority of pregnant women. If this edema produces discomfort, increased recumbency will often provide relief. In rare instances, this edema may cause extreme discomfort which is not relieved by rest. In these cases, a short course of diuretics may provide relief and may be appropriate.

DOSAGE AND ADMINISTRATION

As determined by individual titration (see box warning).

Initial dosages of the combination should conform to those dosages of the individual components established during titration.

Maintenance dosages range from ½ tablet to 2 tablets daily. Dosage of other antihypertensive agents, particularly ganglionic blockers, that are used concomitantly should be reduced.

HOW SUPPLIED

RENESE-R tablets (2 mg polythiazide–0.25 mg reserpine) are available as blue scored tablets,

tablet code 446, in bottles of 100 (NDC 0069-4460 -66) and 1,000

(NDC-0069-4460-82). RENESE-R should be stored at room temperature. Dispense in tight,
light-resistant container.

Rx only

Distributed by:

Pfizer Labs

Division of Pfizer, Inc, NY, NY 10017

69-1200-00-3

September 1995

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