RENESE®-R tablets combine polythiazide and reserpine, two antihypertensive agents with complementary properties. Each blue, scored tablet of RENESE-R provides:
Renese (polythiazide).. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. 2.0 mg
Reserpine. .. .. .. .. .. .. .. .. .. .. .. .. .. .. ... .. .. .. .0.25 mg
RENESE (polythiazide) is a member of the benzothiazide (thiazide) family of diuretic/antihypertensive agents. It is designated chemically as 2H-1,2,4-Benzothiadiazine-7-sulfonamide,6-chloro-3,4-dihydro-2-methyl-3-[[2,2,2-trifluoroethyl)thio]methyl]-,1,1-dioxide with a molecular formula of C11H13ClF3N3O4S3 and a molecular weight of 439.87.
Polythiazide is a white crystalline substance insoluble in water, but readily soluble in alkaline solution, and has the following structural formula:
Reserpine, one of the alkaloids of Rauwolfia serpentina, has the following structural formula:
Reserpine – which is administered orally, is insoluble in water, very slightly soluble in ether, l g in about 1800 mL alcohol and about 6 mL chloroform, slightly soluble in benzene, freely soluble in acetic acid.
It has a molecular weight of 608.69 and its molecular formula is C33H40N2O9. Reserpine is chemically designated as Yohimban-16-carboxylic acid, 11,17-dimethoxy-18-[(3,4,5-trimethoxybenzoyl)oxy]-, methyl ester, (3β,16β,17α,18β,20α)-. It is a white or pale buff to slightly yellowish crystalline powder that is insoluble in water.
Inert Ingredients: FD&C Blue No. 1; dibasic calcium phosphate; lactose; magnesium stearate; polyethylene glycol; sodium lauryl sulfate; starch; vanillin.