Relpax (Eletriptan Hydrobromide) - Summary

RELPAX SUMMARY

RELPAX (eletriptan hydrobromide) tablets contain eletriptan hydrobromide, which is a selective 5-hydroxytryptamine 1B/1D (5-HT1B/1D) receptor agonist.

RELPAX is indicated for the acute treatment of migraine with or without aura in adults.

Limitations of Use:

• Use only if a clear diagnosis of migraine has been established. If a patient has no response to the first migraine attack treated with RELPAX, reconsider the diagnosis of migraine before RELPAX is administered to treat any subsequent attacks.
• RELPAX is not intended for the prevention of migraine attacks.
• Safety and effectiveness of RELPAX have not been established for cluster headache.

NEWS HIGHLIGHTS

Media Articles Related to Relpax (Eletriptan)

Migraines could be predicted with new stress model
Source: Anxiety / Stress News From Medical News Today [2017.07.12]
A migraine can appear from seemingly nowhere, putting you out of action for hours. Scientists are working on ways to predict the approach of these hassles.

Controlled temperature change inside ear can prevent migraines
Source: Headache / Migraine News From Medical News Today [2017.07.10]
The application of gentle cooling and warming currents inside the ear canal can provide relief for migraine sufferers, new research at the University of Kent has helped show.

Cannabinoids could prevent migraine, study finds
Source: Headache / Migraine News From Medical News Today [2017.06.28]
Researchers have found that a combination of THC and CBD - two of marijuana's active compounds - is as effective as existing drugs for preventing migraine.

Study: Exposure to light causes emotional and physical responses in migraine sufferers
Source: Headache / Migraine News From Medical News Today [2017.06.28]
Researchers identify novel connections between neurons in the eye and neurons in the brain.People experiencing migraines often avoid light and find relief in darkness.

Migraine vs. Headache: Differences and Similarities
Source: MedicineNet Facial Nerve Problems Specialty [2017.06.26]
Title: Migraine vs. Headache: Differences and Similarities
Category: Diseases and Conditions
Created: 6/21/2017 12:00:00 AM
Last Editorial Review: 6/26/2017 12:00:00 AM

more news >>

Published Studies Related to Relpax (Eletriptan)

Efficacy of eletriptan in triptan-naive patients: results of a combined analysis. [2007.02]
OBJECTIVE: To compare the efficacy and tolerability of eletriptan 20 mg, 40 mg, and 80 mg in triptan-naive patients (who have not previously used triptans) versus triptan-experienced patients (who have previously used triptans)... CONCLUSIONS: These data suggest that eletriptan has comparable efficacy versus placebo among both triptan-naive and triptan-experienced patients.

Preference for rizatriptan 10-mg wafer vs. eletriptan 40-mg tablet for acute treatment of migraine. [2006.03]
Preference is a composite, patient-oriented endpoint incorporating efficacy, tolerability, formulation, and convenience of medications. The objective of this study was to compare patient preference for rizatriptan 10-mg wafer vs... The single most important reason for preference was speed of relief, consistent with results from previous preference studies.

Eletriptan in the early treatment of acute migraine: influence of pain intensity and time of dosing. [2005.09]
This double-blind, placebo-controlled study was designed to evaluate the efficacy and tolerability of early treatment of a single migraine attack, when headache pain was mild, with two doses (20 mg and 40 mg) of eletriptan. Patients (N = 613; female 79%; mean age 39 years) meeting International Headache Society criteria for migraine were encouraged, but not required, to utilize early treatment, thus providing an opportunity to assess the relative contribution to efficacy of pain severity and timing of dose...

Patient preference for eletriptan 80 mg versus subcutaneous sumatriptan 6 mg: results of a crossover study in patients who have recently used subcutaneous sumatriptan. [2005.02]
This current randomized, open-label, crossover study evaluated preference for oral eletriptan 80 mg compared with subcutaneous sumatriptan 6 mg (suma-sc) amongst patients (n = 311) meeting IHS criteria for migraine who had recently used suma-sc, and found it well tolerated... The results of this study suggest that eletriptan is a strong alternative option for patients who have been prescribed suma-sc.

No effect of eletriptan administration during the aura phase of migraine. [2004.10]
Migraine aura is a warning sign readily recognized by patients... This study confirms the findings of two studies showing that triptans are ineffective but safe when given during the migraine aura phrase.

more studies >>

Clinical Trials Related to Relpax (Eletriptan)

TREXIMA and RELPAX Gastric Scintigraphy Inside and Outside a Migraine [Completed]

Pharmacokinetics of Two Eletriptan Oral Formulations Given With and Without Water and the Commercial Tablet Formulation Given With Water [Completed]
The study will evaluate whether the blood concentrations of eletriptan administered using two test formulations of oral disintegrating tablets are comparable to those observed with the standard commercial tablet.

Prospective Survey of Menstrual Migraine & Prevention With Eletriptan [Completed]
Women are followed prospectively for 3 months, recording headaches, other symptoms, and menstrual periods. Those with menstrual migraine are treated perimenstrually with eletriptan for 3 months.

Eletriptan for the Treatment of Migraine in Patients With Previous Poor Response or Tolerance to Oral Sumatriptan [Completed]
To determine the tolerability and efficacy of eletriptan in patients who had discontinued oral sumatriptan due to lack of efficacy or intolerable adverse events (AEs) during previous clinical treatment (not a controlled trial).

Zolmitriptan Nasal Spray Versus Eletriptan in the Acute Treatment of Migraine [Completed]
The purpose of this study is to Compare the efficacy of zolmitriptan 5 mg nasal spray vs. eletriptan 40 mg tablet in the acute treatment of migraine. To develop and evaluate a set of importance weights for a predefined set of treatment attributes for migraine suffers using zolmitriptan 5 mg nasal spray vs. eletriptan 40 mg tablet. To contrast the efficacy of zolmitriptan 5 mg nasal spray vs. eletriptan 40 mg tablet at early time points. To analyze the patterns of self-reported tolerability of migraine sufferers using zolmitriptan 5 mg nasal spray vs. eletriptan 40 mg tablet.

more trials >>

Reports of Suspected Relpax (Eletriptan) Side Effects

Drug Ineffective (49),  Headache (47),  Migraine (47),  Feeling Abnormal (17),  Depression (15),  Chest Discomfort (13),  Nausea (11),  Fatigue (10),  Vomiting (10),  Pain in Extremity (9), more >>

PATIENT REVIEWS / RATINGS / COMMENTS

Relpax review by 47 year old female patient
		Rating
Overall rating:
Effectiveness:		Highly Effective
Side effects:		No Side Effects
		Treatment Info
Condition / reason:		migraine relief
Dosage & duration:		25mg taken 4x/month for the period of 3 years
Other conditions:		n/a
Other drugs taken:		n/a
		Reported Results
Benefits:		migraine pain relieved in 1 - 2 hours and lasted for 24 hours with 1 tablet
Side effects:		none
Comments:		1 tablet at first signs of headache

Relpax review by 40 year old female patient
		Rating
Overall rating:
Effectiveness:		Considerably Effective
Side effects:		Mild Side Effects
		Treatment Info
Condition / reason:		Migraines
Dosage & duration:		can't remember (dosage frequency: 1 every 24 hrs as needed for migraine) for the period of once a month
Other conditions:		n/a
Other drugs taken:		Pristiq
		Reported Results
Benefits:		It would ease the throbbing feeling associated with a migraine.
Side effects:		Low blood pressure.
Comments:		You could feel a marked difference in your blood pressure, that was the only negative side effect. Other than that, it helped calm the pulsating sensation you would get with an intense migraine. Helping you to relax and feel better.

Relpax review by 39 year old female patient
		Rating
Overall rating:
Effectiveness:		Marginally Effective
Side effects:		Moderate Side Effects
		Treatment Info
Condition / reason:		migraine headaches
Dosage & duration:		.5 (dosage frequency: 2 times per day) for the period of 3 days
Other conditions:		none
Other drugs taken:		birth control
		Reported Results
Benefits:		The medication took almost thirty minutes to kick in. Once the medication started to take affect, I began to develop a tingling sensation in my left hand and later my right hand. I also noticed my hands were very shaky after the medication was in my system for at least an hour.
Side effects:		The medication took almost thirty minutes to kick in. Once the medication started to take affect, I began to develop a tingling sensation in my left hand and later my right hand. I also noticed my hands were very shaky after the medication was in my system for at least an hour.
Comments:		Once a migraine is formulating, one pill is to be taken. The medication took almost thirty minutes to kick in. Once the medication started to take affect, I began to develop a tingling sensation in my left hand and later my right hand. I also noticed my hands were very shaky after the medication was in my system for at least an hour.