RELPAX SUMMARY
RELPAX® (eletriptan hydrobromide) Tablets
RELPAX® (eletriptan) Tablets contain eletriptan hydrobromide, which is a selective 5-hydroxytryptamine 1B/1D (5-HT1B/1D) receptor agonist.
RELPAX is indicated for the acute treatment of migraine with or without aura in adults.
RELPAX is not intended for the prophylactic therapy of migraine or for use in the management of hemiplegic or basilar migraine (see CONTRAINDICATIONS). Safety and effectiveness of RELPAX Tablets have not been established for cluster headache, which is present in an older, predominantly male population.
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NEWS HIGHLIGHTSMedia Articles Related to Relpax (Eletriptan)
Migraine Raises Risk Of Most Common Form Of Stroke
Source: Headache / Migraine News From Medical News Today [2009.11.17]
Pooling results from 21 studies, involving 622,381 men and women, researchers at Johns Hopkins have affirmed that migraine headaches are associated with more than twofold higher chances of the most common kind of stroke: those occurring when blood supply to the brain is suddenly cut off by the buildup of plaque or a blood clot. The risk for those with migraines is 2.3 times those without, according to calculations from the Johns Hopkins team, to be presented Nov.
Migraine Increases Likelihood of Stroke
Source: MedicineNet Birth Control Specialty [2009.11.17]
Title: Migraine Increases Likelihood of Stroke
Category: Health News
Created: 11/16/2009 12:10:00 PM
Last Editorial Review: 11/17/2009
Molecular Imaging Pinpoints Inflammation In The Brains Of Schizophrenics And Migraine Sufferers
Source: Headache / Migraine News From Medical News Today [2009.11.02]
Inflammatory response of brain cells - as indicated by a molecular imaging technique - could tell researchers more about why certain neurologic disorders, such as migraine headaches and psychosis in schizophrenic patients, occur and provide insight into how to best treat them, according to two studies published in the November issue of The Journal of Nuclear Medicine.
Migraine With Aura Is Associated With Increased Risk Of Stroke
Source: Headache / Migraine News From Medical News Today [2009.10.29]
A migraine with aura occurs when temporary visual or sensory disturbances are experienced before or during a migraine headache. A study just published on bmj.com reports that migraine with aura is associated with a twofold increased risk of stroke. Further risk factors for stroke among patients with migraine are being a woman, being young, being a smoker, and using contraceptives containing estrogen.
Migraine With Aura Doubles The Risk Of Stroke
Source: Headache / Migraine News From Medical News Today [2009.10.28]
Migraine with aura (temporary visual or sensory disturbances before or during a migraine headache) is associated with a twofold increased risk of stroke, finds a study published on bmj.com today. Further risk factors for stroke among patients with migraine are being a woman, being young, being a smoker, and using oestrogen containing contraceptives.
Published Studies Related to Relpax (Eletriptan)
Efficacy of eletriptan in triptan-naive patients: results of a combined analysis. [2007.02]
OBJECTIVE: To compare the efficacy and tolerability of eletriptan 20 mg, 40 mg, and 80 mg in triptan-naive patients (who have not previously used triptans) versus triptan-experienced patients (who have previously used triptans)... CONCLUSIONS: These data suggest that eletriptan has comparable efficacy versus placebo among both triptan-naive and triptan-experienced patients.
Preference for rizatriptan 10-mg wafer vs. eletriptan 40-mg tablet for acute treatment of migraine. [2006.03]
Preference is a composite, patient-oriented endpoint incorporating efficacy, tolerability, formulation, and convenience of medications. The objective of this study was to compare patient preference for rizatriptan 10-mg wafer vs... The single most important reason for preference was speed of relief, consistent with results from previous preference studies.
Eletriptan in the early treatment of acute migraine: influence of pain intensity and time of dosing. [2005.09]
This double-blind, placebo-controlled study was designed to evaluate the efficacy and tolerability of early treatment of a single migraine attack, when headache pain was mild, with two doses (20 mg and 40 mg) of eletriptan. Patients (N = 613; female 79%; mean age 39 years) meeting International Headache Society criteria for migraine were encouraged, but not required, to utilize early treatment, thus providing an opportunity to assess the relative contribution to efficacy of pain severity and timing of dose...
Patient preference for eletriptan 80 mg versus subcutaneous sumatriptan 6 mg: results of a crossover study in patients who have recently used subcutaneous sumatriptan. [2005.02]
This current randomized, open-label, crossover study evaluated preference for oral eletriptan 80 mg compared with subcutaneous sumatriptan 6 mg (suma-sc) amongst patients (n = 311) meeting IHS criteria for migraine who had recently used suma-sc, and found it well tolerated... The results of this study suggest that eletriptan is a strong alternative option for patients who have been prescribed suma-sc.
No effect of eletriptan administration during the aura phase of migraine. [2004.10]
Migraine aura is a warning sign readily recognized by patients... This study confirms the findings of two studies showing that triptans are ineffective but safe when given during the migraine aura phrase.
Clinical Trials Related to Relpax (Eletriptan)
TREXIMA and RELPAX Gastric Scintigraphy Inside and Outside a Migraine [Completed]
A Trial to Study of the Effects of Eletriptan 40mg on Mild vs Moderate to Severe Pain Intensity of Migraine [Completed]
To evaluate the efficacy of early intervention (dosing within 2 hours of onset of the
migraine attack) with eletriptan 40mg on mild versus moderate to severe pain intensity of
migraine.
Prospective Survey of Menstrual Migraine & Prevention With Eletriptan [Recruiting]
Women are followed prospectively for 3 months, recording headaches, other symptoms, and
menstrual periods. Those with menstrual migraine are treated perimenstrually with eletriptan
for 3 months.
Efficacy and Safety of Eletriptan for the Treatment of Migraine in Patients Not Satisfied With Rizatriptan Therapy [Completed]
To assess the efficacy and safety of eletriptan for migraine headaches in subjects who were
not satisfied with rizatriptan therapy
Safety and Efficacy of Eletriptan for the Treatment of Migraine in Subjects Unsuccessfully Treated With Nonsteroidal Anti-Inflammatory Drugs [Completed]
To assess the safety and efficacy of eletriptan for the treatment of migraine in subjects who
had not been adequately treated with non-steroidal antiinflammatory drugs (NSAIDs)
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PATIENT REVIEWS / RATINGS / COMMENTSBased on a total of 4 ratings/reviews, Relpax has an overall score of 9. The effectiveness score is 9 and the side effect score is 9. The scores are on ten point scale: 10 - best, 1 - worst. Below are selected reviews: the highest, the median and the lowest rated.
| | Relpax review by 47 year old female patient | | | Rating |
| Overall rating: | |  |
| Effectiveness: | | Highly Effective |
| Side effects: | | No Side Effects | | |
Treatment Info |
| Condition / reason: | | migraine relief |
| Dosage & duration: | | 25mg taken 4x/month for the period of 3 years |
| Other conditions: | | n/a |
| Other drugs taken: | | n/a | | |
Reported Results |
| Benefits: | | migraine pain relieved in 1 - 2 hours and lasted for 24 hours with 1 tablet |
| Side effects: | | none |
| Comments: | | 1 tablet at first signs of headache |
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| | Relpax review by 55 year old female patient | | | Rating |
| Overall rating: | |  |
| Effectiveness: | | Considerably Effective |
| Side effects: | | Mild Side Effects | | |
Treatment Info |
| Condition / reason: | | migraine |
| Dosage & duration: | | 40mg taken 2xa week for the period of 3 yrs. |
| Other conditions: | | high cholesterol and anxiety |
| Other drugs taken: | | zetia and lexapro | | |
Reported Results |
| Benefits: | | if taken within the first hour of of your personal migraine symtoms the med. works very well. usually within an hour you can control the nausea and light sensitivity with only a little sleepiness.it only takes about 30 to 60 minutes to take effect so if you catch it early you can forego almost all your pain. |
| Side effects: | | the main side effects for me are sleepiness and moodiness. the sleepiness can be good if you have time to rest for a couple of hours..if not... it can be a little difficult to navigate through the day. the moodiness for me may simply be my depression over having another migraine...i am always hoping my last migraine was my last. |
| Comments: | | take one tablet on the onset of headache..usually if i take it within the first 30 min. i can control the nausea that accompanies the migraine...if i wait too long the med. doesn't work very well. also the ins. company limits me to 8 pills a month so if have to be very dilligent about taking the med. right away or i will have to take a second one a few hours later....they are too precious to use that much |
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| | Relpax review by 55 year old female patient | | | Rating |
| Overall rating: | | |
| Effectiveness: | | Considerably Effective |
| Side effects: | | Mild Side Effects | | |
Treatment Info |
| Condition / reason: | | migraine |
| Dosage & duration: | | 40mg taken 2xa week for the period of 3 yrs. |
| Other conditions: | | high cholesterol and anxiety |
| Other drugs taken: | | zetia and lexapro | | |
Reported Results |
| Benefits: | | if taken within the first hour of of your personal migraine symtoms the med. works very well. usually within an hour you can control the nausea and light sensitivity with only a little sleepiness.it only takes about 30 to 60 minutes to take effect so if you catch it early you can forego almost all your pain. |
| Side effects: | | the main side effects for me are sleepiness and moodiness. the sleepiness can be good if you have time to rest for a couple of hours..if not... it can be a little difficult to navigate through the day. the moodiness for me may simply be my depression over having another migraine...i am always hoping my last migraine was my last. |
| Comments: | | take one tablet on the onset of headache..usually if i take it within the first 30 min. i can control the nausea that accompanies the migraine...if i wait too long the med. doesn't work very well. also the ins. company limits me to 8 pills a month so if have to be very dilligent about taking the med. right away or i will have to take a second one a few hours later....they are too precious to use that much |
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Page last updated: 2009-11-17
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