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Relistor (Methylnaltrexone Bromide Subcutaneous) - Summary



RELISTOR (methylnaltrexone bromide) injection, a peripherally-acting mu-opioid receptor antagonist, is a sterile, clear and colorless to pale yellow aqueous solution.

RELISTOR® is indicated for the treatment of opioid-induced constipation in patients with advanced illness who are receiving palliative care, when response to laxative therapy has not been sufficient.

Limitation of use: Use of RELISTOR beyond four months has not been studied in the advanced illness population.

See all Relistor indications & dosage >>


Media Articles Related to Relistor (Methylnaltrexone Subcutaneous)

Constipation: Foods to Eat, Foods to Avoid
Source: MedicineNet Constipation Specialty [2015.09.17]
Title: Constipation: Foods to Eat, Foods to Avoid
Category: MedicineNet Quiz
Created: 9/17/2015 1:55:00 PM
Last Editorial Review: 9/17/2015 5:16:14 PM

Top 12 Foods That Cause Constipation
Source: MedicineNet Anal Fissure Specialty [2015.08.27]
Title: Top 12 Foods That Cause Constipation
Category: Diseases and Conditions
Created: 8/26/2015 12:00:00 AM
Last Editorial Review: 8/27/2015 12:00:00 AM

Top 12 Foods for Constipation Relief
Source: MedicineNet Constipation Specialty [2015.08.25]
Title: Top 12 Foods for Constipation Relief
Category: Diseases and Conditions
Created: 8/28/2013 12:00:00 AM
Last Editorial Review: 8/25/2015 12:00:00 AM

Source: MedicineNet Amyotrophic Lateral Sclerosis Specialty [2015.07.16]
Title: Constipation
Category: Diseases and Conditions
Created: 12/31/1997 12:00:00 AM
Last Editorial Review: 7/16/2015 12:00:00 AM

First licensed therapy for moderate-to-severe irritable bowel syndrome with constipation (IBS-C) included in NICE Guideline
Source: Irritable-Bowel Syndrome News From Medical News Today [2015.03.19]
Almirall welcomes the inclusion of Constella (linaclotide)1 within the irritable bowel syndrome (IBS) NICE Guideline CG61 (Update) for use in adult patients and recognises the opportunity this will...

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Published Studies Related to Relistor (Methylnaltrexone Subcutaneous)

Subcutaneous methylnaltrexone for treatment of acute opioid-induced constipation: phase 2 study in rehabilitation after orthopedic surgery. [2012]
patients with acute OIC after orthopedic procedures... CONCLUSIONS: Methylnaltrexone was generally well tolerated and was active in

Safety and efficacy of methylnaltrexone in shortening the duration of postoperative ileus following segmental colectomy: results of two randomized, placebo-controlled phase 3 trials. [2011.05]
PURPOSE: Postoperative ileus contributes to surgical morbidity and is associated with prolonged hospitalization and increased health care costs. The efficacy and safety of the peripherally acting mu-opioid receptor antagonist methylnaltrexone in shortening the duration of postoperative ileus following segmental colectomy was evaluated... CONCLUSIONS: Although the efficacy of methylnaltrexone in reducing the duration of postoperative ileus was not demonstrated in these studies, intravenous methylnaltrexone at doses of 12 mg and 24 mg was safe, in general, and well tolerated in postcolectomy patients. The utility of intravenous methylnaltrexone in treating postoperative ileus remains unproven.

Subcutaneous methylnaltrexone for treatment of opioid-induced constipation in patients with chronic, nonmalignant pain: a randomized controlled study. [2011.05]
Methylnaltrexone is effective for opioid-induced constipation (OIC) in advanced illness patients. This 4-week, double-blind, randomized, placebo-controlled study investigated the effect of subcutaneous methylnaltrexone on OIC in patients receiving opioids for chronic, nonmalignant pain...

Effect of subcutaneous methylnaltrexone on patient-reported constipation symptoms. [2011.01]
BACKGROUND: Methylnaltrexone, a selective peripheral acting mu-opioid receptor antagonist, alleviates the constipating effects of opioids without affecting centrally mediated analgesia. OBJECTIVES: To assess the effect of subcutaneous (SC) methylnaltrexone injection on patient-reported constipation symptoms and pain scores... CONCLUSION: The results of our study indicate significant improvement in constipation symptoms with methylnaltrexone QD or QOD dosing compared to placebo without a significant effect on pain scores. Copyright (c) 2011 International Society for Pharmacoeconomics and Outcomes Research (ISPOR). Published by Elsevier Inc. All rights reserved.

Characterization of abdominal pain during methylnaltrexone treatment of opioid-induced constipation in advanced illness: a post hoc analysis of two clinical trials. [2011]
studies... CONCLUSION: Abdominal pain AEs in methylnaltrexone-treated patients in clinical

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Clinical Trials Related to Relistor (Methylnaltrexone Subcutaneous)

Methylnaltrexone for Opioid-induced Constipation in Cancer Patients [Completed]

Methylnaltrexone Pharmacokinetics in Neurointensive Care Patients [Recruiting]

- Assessment of pharmacokinetic parameters of once daily subcutaneously administered

methylnaltrexone in 10 evaluable neurointensive care patients.

- Quantification of methylnaltrexone passage through the blood-brain-barrier in

critically ill patients with severe cerebral affections.

- Observation of laxation response after methylnaltrexone application and relation to

plasma concentrations of methylnaltrexone.

- Assessing the safety of once daily administered methylnaltrexone in neurointensive care


- Trial with medicinal product

Effect of Methylnaltrexone on GI Transit in Healthy Volunteers [Completed]
This is a single-center, randomized, double blind, placebo-controlled study evaluating the effects of placebo, codeine, methylnaltrexone and codeine with methylnaltrexone on gastrointestinal motility and colonic transit of solids in healthy human subjects. The hypotheses are: 1. Methylnaltrexone administered subcutaneously enhances gastrointestinal motility with acceleration of overall colonic transit, and ascending colon emptying of solids in healthy humans. 2. Methylnaltrexone significantly accelerates colonic transit that is delayed by codeine

Methylnaltrexone for Treatment of Opiate-Induced Constipation in the Intensive Care Unit [Recruiting]
The purpose of this study is to determine if there will be a significantly higher incidence of a bowel movement with methylnaltrexone vs. placebo within 4 hours +- 45 minutes with decreased need for rescue medications in the intensive care unit in patients with opioid-induced constipation. Patients will also be managed with an aggressive bowel management protocol.

Effect of Methylnaltrexone on the PK/PD Profiles of Ticagrelor in Patients Treated With Morphine [Not yet recruiting]
Ticagrelor is associated with more prompt and potent antiplatelet effects compared with clopidogrel, leading to better clinical outcomes, including reduced cardiovascular mortality, across the spectrum of patients with acute coronary syndrome, including those with ST-elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PCI). However, in this latter setting a delay in the onset of its antiplatelet effects has been shown. Morphine has been identified as a cause of delayed P2Y12 inhibition in patients with STEMI. Methylnaltrexone is a parenteral peripheral opioid receptor antagonist which has the potential to prevent or reverse opioid-induced peripherally mediated side effects without affecting analgesia. However, whether the use of intravenous methylnaltrexone may overcome the effects of morphine administration on the pharmacokinetic (PK) and pharmacodynamics (PD) profiles of ticagrelor has not been investigated yet. The proposed investigation will include patients with coronary artery disease and will have a prospective, randomized, cross-over design.

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Reports of Suspected Relistor (Methylnaltrexone Subcutaneous) Side Effects

Vomiting (3)Nausea (3)Mental Status Changes (2)Metabolic Acidosis (2)Hypotension (2)NO Therapeutic Response (2)Agitation (1)Confusional State (1)Haematocrit Decreased (1)Abdominal Distension (1)more >>

Page last updated: 2015-09-17

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