Carcinogenesis, Mutagenesis, Impairment of Fertility
RELISTOR (methylnaltrexone bromide) Subcutaneous Injection, a peripherally-acting mu-opioid receptor antagonist, is a sterile, clear and colorless to pale yellow aqueous solution.
RELISTOR is indicated for the treatment of opioid-induced constipation in patients with advanced illness who are receiving palliative care, when response to laxative therapy has not been sufficient. Use of RELISTOR beyond four months has not been studied.
Media Articles Related to Relistor (Methylnaltrexone Subcutaneous)
FDA approves Movantik for opioid-induced constipation
Source: GastroIntestinal / Gastroenterology News From Medical News Today [2014.09.19]
The U.S. Food and Drug Administration has approved Movantik (naloxegol), an oral treatment for opioid-induced constipation in adults with chronic non-cancer pain.
Movantik Approved for Constipation From Opioids
Source: MedicineNet Constipation Specialty [2014.09.17]
Title: Movantik Approved for Constipation From Opioids
Category: Health News
Created: 9/16/2014 2:36:00 PM
Last Editorial Review: 9/17/2014 12:00:00 AM
FDA Okays Naloxegol (Movantik) in Opioid-Induced Constipation
Source: Medscape NeurologyHeadlines [2014.09.16]
Approval comes following results of 2 studies showing the drug is safe and effective.
Drug for Opioid Constipation Wins OK
Source: MedPage Today Gastroenterology [2014.09.16]
(MedPage Today) -- Patients experiencing opioid-induced constipation will have another treatment option, thanks to the FDA's approval of naloxegol (Movantik) on Tuesday.
A form of acupuncture may help relieve chronic constipation
Source: Complementary Medicine / Alternative Medicine News From Medical News Today [2014.08.27]
Nearly 1 in 6 adults worldwide may suffer from chronic constipation and, over time, the disorder can cause serious complications.
Published Studies Related to Relistor (Methylnaltrexone Subcutaneous)
Subcutaneous methylnaltrexone for treatment of acute opioid-induced constipation:
phase 2 study in rehabilitation after orthopedic surgery. 
patients with acute OIC after orthopedic procedures... CONCLUSIONS: Methylnaltrexone was generally well tolerated and was active in
Safety and efficacy of methylnaltrexone in shortening the duration of postoperative ileus following segmental colectomy: results of two randomized, placebo-controlled phase 3 trials. [2011.05]
PURPOSE: Postoperative ileus contributes to surgical morbidity and is associated with prolonged hospitalization and increased health care costs. The efficacy and safety of the peripherally acting mu-opioid receptor antagonist methylnaltrexone in shortening the duration of postoperative ileus following segmental colectomy was evaluated... CONCLUSIONS: Although the efficacy of methylnaltrexone in reducing the duration of postoperative ileus was not demonstrated in these studies, intravenous methylnaltrexone at doses of 12 mg and 24 mg was safe, in general, and well tolerated in postcolectomy patients. The utility of intravenous methylnaltrexone in treating postoperative ileus remains unproven.
Subcutaneous methylnaltrexone for treatment of opioid-induced constipation in patients with chronic, nonmalignant pain: a randomized controlled study. [2011.05]
Methylnaltrexone is effective for opioid-induced constipation (OIC) in advanced illness patients. This 4-week, double-blind, randomized, placebo-controlled study investigated the effect of subcutaneous methylnaltrexone on OIC in patients receiving opioids for chronic, nonmalignant pain...
Effect of subcutaneous methylnaltrexone on patient-reported constipation symptoms. [2011.01]
BACKGROUND: Methylnaltrexone, a selective peripheral acting mu-opioid receptor antagonist, alleviates the constipating effects of opioids without affecting centrally mediated analgesia. OBJECTIVES: To assess the effect of subcutaneous (SC) methylnaltrexone injection on patient-reported constipation symptoms and pain scores... CONCLUSION: The results of our study indicate significant improvement in constipation symptoms with methylnaltrexone QD or QOD dosing compared to placebo without a significant effect on pain scores. Copyright (c) 2011 International Society for Pharmacoeconomics and Outcomes Research (ISPOR). Published by Elsevier Inc. All rights reserved.
Characterization of abdominal pain during methylnaltrexone treatment of
opioid-induced constipation in advanced illness: a post hoc analysis of two
clinical trials. 
studies... CONCLUSION: Abdominal pain AEs in methylnaltrexone-treated patients in clinical
Clinical Trials Related to Relistor (Methylnaltrexone Subcutaneous)
Methylnaltrexone for Opioid-induced Constipation in Cancer Patients [Recruiting]
Methylnaltrexone for Treatment of Opiate-Induced Constipation in the Intensive Care Unit [Recruiting]
The purpose of this study is to determine if there will be a significantly higher incidence
of a bowel movement with methylnaltrexone vs. placebo within 4 hours +- 45 minutes with
decreased need for rescue medications in the intensive care unit in patients with
opioid-induced constipation. Patients will also be managed with an aggressive bowel
Can Methylnaltrexone Safely Treat Opioid Related Constipation in the Emergency Department? [Recruiting]
The investigators want to prove that people WITHOUT advanced cancer who are taking opioid
medications (for problems like back pain) can receive methylnaltrexone (MNTX) safely. Since
the FDA has only approved MNTX for advanced cancer patients, the investigators' research is
investigating how MNTX can work for NON-cancer patients. This research is being conducted to
prove that MNTX can work for non-cancer patients with opioid related constipation.
Methylnaltrexone Use for Opioid-induced Postoperative Constipation [Not yet recruiting]
The purpose of this study is to determine whether the routine use of methylnaltrexone in the
post-operative pediatric spinal fusion patient will decrease the incidence of constipation.
Methylnaltrexone vs Erythromycin for Facilitating Gastric Emptying Time in Critically Ill Patients [Recruiting]
42 patients admitted in ICU with intolerance to enteral feeding (GRV more than 250 ml) are
recruited. All patients enter a primary acetaminophen absorption test study as baseline.
Serum levels of acetaminophen will be measured by florescence polarization method at
15,30,45,60,90,120,180,240,480 minutes after enteral administration of 975 mg acetaminophen.
Then the patients will be randomized to methylnaltrexone or erythromycin group. Another
acetaminophen absorption test with the same schedule will be done after the last dose of
each drug. The area under the curve for acetaminophen blood level will be used to compare the
effect of two studied drugs on gastric emptying time.
Reports of Suspected Relistor (Methylnaltrexone Subcutaneous) Side Effects
Mental Status Changes (2),
Metabolic Acidosis (2),
NO Therapeutic Response (2),
Confusional State (1),
Haematocrit Decreased (1),
Abdominal Distension (1), more >>