REGLAN SUMMARY
REGLAN Injection (metoclopramide injection, USP)
Rx only
Metoclopramide hydrochloride is a white crystalline, odorless substance, freely soluble in water.
Diabetic Gastroparesis (Diabetic Gastric Stasis)
REGLAN (metoclopramide hydrochloride, USP) is indicated for the relief of symptoms associated with acute and recurrent diabetic gastric stasis.
The Prevention of Nausea and Vomiting Associated with Emetogenic Cancer Chemotherapy
REGLAN Injection is indicated for the prophylaxis of vomiting associated with emetogenic cancer chemotherapy.
The Prevention of Postoperative Nausea and Vomiting
REGLAN Injection is indicated for the prophylaxis of postoperative nausea and vomiting in those circumstances where nasogastric suction is undesirable.
Small Bowel Intubation
REGLAN Injection may be used to facilitate small bowel intubation in adults and pediatric patients in whom the tube does not pass the pylorus with conventional maneuvers.
Radiological Examination
REGLAN Injection may be used to stimulate gastric emptying and intestinal transit of barium in cases where delayed emptying interferes with radiological examination of the stomach and/or small intestine.
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NEWS HIGHLIGHTSMedia Articles Related to Reglan (Metoclopramide)
Metoclopramide Drugs Get 'Black Box' Warning
Source: MedicineNet Gastroparesis Specialty [2009.03.02]
Title: Metoclopramide Drugs Get 'Black Box' Warning
Category: Health News
Created: 3/2/2009
Last Editorial Review: 3/2/2009
Published Studies Related to Reglan (Metoclopramide)
Comparison of the efficacy of propofol and metoclopramide in preventing postoperative nausea and vomiting after middle ear surgery. [2009.06]
OBJECTIVE: To compare the administration of sub hypnotic dose of propofol with metoclopramide and placebo in prevention of postoperative nausea and vomiting (PONV) after middle ear surgery... CONCLUSION: The administration of a sub hypnotic dose of propofol at the end of surgery was found to be at least as effective as metoclopramide in preventing PONV in the early postoperative period in adult patients undergoing middle ear surgery.
Slower infusion of metoclopramide decreases the rate of akathisia. [2009.05]
OBJECTIVE: We investigated the difference in incidence of acute akathisia related to the rate of infusion in patients receiving metoclopramide for acute nausea, vomiting, or migraine headache in the emergency department (ED)... CONCLUSIONS: Slower infusion of metoclopramide reduces the incidence of akathisia.
A randomized trial of diphenhydramine as prophylaxis against metoclopramide-induced akathisia in nauseated emergency department patients. [2009.03]
STUDY OBJECTIVE: Akathisia, an adverse effect observed at times after administration of parenteral metoclopramide, is an unpleasant symptom complex characterized by restlessness and agitation. Some try to limit the development of akathisia by coadministering diphenhydramine when using parenteral metoclopramide. The goal of this investigation is to determine whether concomitant administration of diphenhydramine 25 mg decreased the rate of development of akathisia after administration of 10 mg or 20 mg of intravenous metoclopramide... CONCLUSION: Routine prophylaxis with diphenhydramine to prevent akathisia is unwarranted when intravenous metoclopramide is administered over 15 minutes. For patients administered 20 mg of metoclopramide, prophylactic diphenhydramine may decrease subjective restlessness.
The Effect of Metoclopramide in Capsule Enteroscopy. [2009.01.29]
Clinical utility of prokinetics in capsule endoscopy (CE) is not clearly established. The objective of this prospective, randomized, single-blind, controlled trial was to determine if metoclopramide is useful in CE by increasing the rate of complete enteroscopy...
A randomized controlled trial of prochlorperazine versus metoclopramide for treatment of acute migraine. [2008.10]
STUDY OBJECTIVE: We compare prochlorperazine 10 mg intravenously versus metoclopramide 20 mg intravenously for the emergency department (ED) treatment of acute migraine... CONCLUSION: Either prochlorperazine 10 mg intravenously or metoclopramide 20 mg intravenously, combined with diphenhydramine 25 mg intravenously, is an efficacious treatment for ED patients with acute migraine. Three quarters of subjects in both arms would want the same medication for their next migraine.
Clinical Trials Related to Reglan (Metoclopramide)
A Randomized, Open-Label, Two-Way Crossover Trial to Determine the Pharmacokinetics of Metoclopramide When Administered as the Orally Disintegrating Tablet Compared to Reglan® Tablets in Subjects With Diabetic Gastroparesis [Completed]
To determine whether a new Orally Disintegrating Tablet of Reglan (metoclopramide) is
metabolized faster than the conventional Reglan tablet in patients with diabetic
gastroparesis, pharmacokinetics following a single 10 mg dose of each formulation are being
compared. Subjects must be 18 or older, have Type 1 or 2 diabetes with documented
gastroparesis and agree to withhold medications for gastroparesis for 3 days prior to each
dosing. Exclusion criteria include serum glucose >300 mg/dL, Hb1Ac >10%, and concurrent
illness interfering with gastrointestinal motility. Subjects will stay in the clinic
overnight, and pharmacokinetic sampling will continue for 8 hours after the first morning
dose. The time (Tmax) and amount (Cmax) of peak concentration and the area under the curve
(AUC) from time zero to 8 hr will be compared for the 2 formulations.
MgSO4 vs Metoclopramide for Headache in Pregnant Women [Recruiting]
The study will compare effectiveness of intravenous magnesium sulfate to that of intravenous
metoclopramide (Reglan®) for acute headache in pregnant women. We will randomize pregnant
women who present to our emergency department with chief complaint of headache to magnesium
sulfate 2 grams intravenously or metoclopramide 10 mg intravenously; both groups will
receive acetaminophen (Tylenol®) 1 gram orally and normal saline 1 liter intravenously.
Headaches are common during pregnancy, related to hormonal changes, altered sleep patterns
and psychosocial stressors. Common medications for headache such as non-steroidal
antiinflammatories or triptans are typically avoided during pregnancy due to concern for
fetal effects. Women, and their physicians, are often uncertain regarding available
medication options with justifiable safety profiles during pregnancy.
Comparison of Ondansetron, Metoclopramide and Promethazine for the Treatment of Nausea and Vomiting in the Adult ED [Recruiting]
Metoclopramide for Acute Migraine: A Dose Finding Study [Recruiting]
Metoclopramide is an effective intravenous treatment for acute migraine attacks, but we do
not know the bets dose to administer. This study compares three different doses of
metoclorpamide.
Efficacy and Safety of Metoclopramide Nasal Spray Solution in Diabetic Patients With Gastroparesis [Recruiting]
To evaluate the safety and the effectiveness of two doses of metoclopramide nasal spray
solution, 10 mg and 14 mg, compared to placebo in reducing the symptoms of diabetic
gastroparesis.
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PATIENT REVIEWS / RATINGS / COMMENTSBased on a total of 3 ratings/reviews, Reglan has an overall score of 5. The effectiveness score is 5.33 and the side effect score is 10. The scores are on ten point scale: 10 - best, 1 - worst.
| | Reglan review by 50 year old female patient | | | Rating |
| Overall rating: | |  |
| Effectiveness: | | Highly Effective |
| Side effects: | | No Side Effects | | |
Treatment Info |
| Condition / reason: | | delayed gastric emptying-nausea |
| Dosage & duration: | | 5 mg taken daily for the period of couple years |
| Other conditions: | | none |
| Other drugs taken: | | none | | |
Reported Results |
| Benefits: | | It worked great! I would not be nauseated at all and could eat and have energy all day. |
| Side effects: | | none, but the doc stopped it as I started needing it less, aid there would be too much risk of weird symptoms. I still miss it and wish I could have it back. But I am not as sick or as often I was. It was just stress and a job change helped also. |
| Comments: | | I took in the am when nauseated, I would take again if needed but after a while it worked all day for me. I took as little as possible as I am not a big pill taker |
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| | Reglan review by 52 year old female patient | | | Rating |
| Overall rating: | |  |
| Effectiveness: | | Ineffective |
| Side effects: | | No Side Effects | | |
Treatment Info |
| Condition / reason: | | ulcers that caused throwing up |
| Dosage & duration: | | 10 mg taken before meals for the period of 2 years |
| Other conditions: | | GERD |
| Other drugs taken: | | tagamet | | |
Reported Results |
| Benefits: | | took the reglan to try to empty my stomach before i threw up and the reglan didnt work - the tagamet helped - scale 1-10 a 10 |
| Side effects: | | didn't notice any |
| Comments: | | chronic ulcers - my tube that carries the food to the stomach had an opening the diameter of a pencil - the reglan was to help empty my stomach once the food finally got there - otherwise it would sit there because my stomach was tilted and the food couldn't drain easily and therefore the stomach acids would keep eating at the food and also the ulcers till they could never quit bleeding - 3 stomach surgeries later and no stomach left to cut away i am healed and need no medications not even mylanta or tums |
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| | Reglan review by 52 year old female patient | | | Rating |
| Overall rating: | | |
| Effectiveness: | | Ineffective |
| Side effects: | | No Side Effects | | |
Treatment Info |
| Condition / reason: | | ulcers that caused throwing up |
| Dosage & duration: | | 10 mg taken before meals for the period of 2 years |
| Other conditions: | | GERD |
| Other drugs taken: | | tagamet | | |
Reported Results |
| Benefits: | | took the reglan to try to empty my stomach before i threw up and the reglan didnt work - the tagamet helped - scale 1-10 a 10 |
| Side effects: | | didn't notice any |
| Comments: | | chronic ulcers - my tube that carries the food to the stomach had an opening the diameter of a pencil - the reglan was to help empty my stomach once the food finally got there - otherwise it would sit there because my stomach was tilted and the food couldn't drain easily and therefore the stomach acids would keep eating at the food and also the ulcers till they could never quit bleeding - 3 stomach surgeries later and no stomach left to cut away i am healed and need no medications not even mylanta or tums |
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Page last updated: 2009-10-20
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