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Reglan (Metoclopramide Hydrochloride) - Summary

 
 



REGLAN SUMMARY

REGLAN Injection (metoclopramide injection, USP)
Rx only

Metoclopramide hydrochloride is a white crystalline, odorless substance, freely soluble in water.

Diabetic Gastroparesis (Diabetic Gastric Stasis)

REGLAN (metoclopramide hydrochloride, USP) is indicated for the relief of symptoms associated with acute and recurrent diabetic gastric stasis.

The Prevention of Nausea and Vomiting Associated with Emetogenic Cancer Chemotherapy

REGLAN Injection is indicated for the prophylaxis of vomiting associated with emetogenic cancer chemotherapy.

The Prevention of Postoperative Nausea and Vomiting

REGLAN Injection is indicated for the prophylaxis of postoperative nausea and vomiting in those circumstances where nasogastric suction is undesirable.

Small Bowel Intubation

REGLAN Injection may be used to facilitate small bowel intubation in adults and pediatric patients in whom the tube does not pass the pylorus with conventional maneuvers.

Radiological Examination

REGLAN Injection may be used to stimulate gastric emptying and intestinal transit of barium in cases where delayed emptying interferes with radiological examination of the stomach and/or small intestine.


See all Reglan indications & dosage >>

NEWS HIGHLIGHTS

Published Studies Related to Reglan (Metoclopramide)

A trial of midazolam vs diphenhydramine in prophylaxis of metoclopramide-induced akathisia. [2012.01]
STUDY OBJECTIVE: The study aimed to evaluate the effects of midazolam and diphenhydramine for the prevention of metoclopramide-induced akathisia... CONCLUSION: Coadministered midazolam reduced the incidence of akathisia induced by metoclopramide compared to placebo but increased the rate of sedation. No difference was detected from diphenhydramine. Routine coadministered 20 mg diphenhydramine did not prevent metoclopramide-induced akathisia. Copyright (c) 2012 Elsevier Inc. All rights reserved.

Metoclopramide to augment lactation, does it work? A randomized trial. [2011.11]
OBJECTIVES: The objective of this study was to investigate the efficacy of metoclopramide on augmentation of milk production in mothers of premature newborns... CONCLUSION: In mothers with preterm babies, metoclopramide treatment does not augment (sample size had 80% power for detection of 50% difference) the breast milk production. Maternal interest, education, and support are recognized as mainstay in accomplishing successful lactation.

Intramuscular injection of metoclopramide decreases the gastric transit time and does not increase the complete examination rate of capsule endoscopy: a prospective randomized controlled trial. [2011.09]
CONCLUSIONS: Intramuscular injection of metoclopramide decreases the gastric transit time, but it does not change the SBTT or CER of capsule endoscopy in our study.

Metoclopramide as an analgesic in severe migraine attacks: an open, single-blind, parallel control study. [2011.05.01]
Metoclopramide is a well-known anti-emetic drug with central and peripheral pharmacological effects. Some authors have reported metoclopramide as an adjunct therapy to other analgesics in patients with migraine attacks...

Comparison of the pharmacokinetics of a new 15-mg modified-release tablet formulation of metoclopramide versus a 10-mg immediate-release tablet: a single- and multiple-dose, randomized, open-label, parallel-group study in healthy Mexican male volunteers. [2011.05]
BACKGROUND: Metoclopramide is a prokinetic and antiemetic agent. OBJECTIVE: The goal of this study was to assess the pharmacokinetics of a new, modified-release metoclopramide tablet and compare it with an immediate-release tablet to obtain marketing approval from the Mexican regulatory agency... CONCLUSIONS: This study in a sample of selected healthy Mexican male volunteers suggests that the metoclopramide15-mg modified-release tablets have features compatible with the slow-release formulation (lower C(max) and longer T(max)) compared with immediate-release tablets. Copyright (c) 2011 Elsevier HS Journals, Inc. All rights reserved.

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Clinical Trials Related to Reglan (Metoclopramide)

MgSO4 vs Metoclopramide for Headache in Pregnant Women [Recruiting]
The study will compare effectiveness of intravenous magnesium sulfate to that of intravenous metoclopramide (Reglan®) for acute headache in pregnant women. We will randomize pregnant women who present to our emergency department with chief complaint of headache to magnesium sulfate 2 grams intravenously or metoclopramide 10 mg intravenously; both groups will receive acetaminophen (Tylenol®) 1 gram orally and normal saline 1 liter intravenously. Headaches are common during pregnancy, related to hormonal changes, altered sleep patterns and psychosocial stressors. Common medications for headache such as non-steroidal antiinflammatories or triptans are typically avoided during pregnancy due to concern for fetal effects. Women, and their physicians, are often uncertain regarding available medication options with justifiable safety profiles during pregnancy.

A Randomized, Open-Label, Two-Way Crossover Trial to Determine the Pharmacokinetics of Metoclopramide When Administered as the Orally Disintegrating Tablet Compared to Reglan® Tablets in Subjects With Diabetic Gastroparesis [Completed]
To determine whether a new Orally Disintegrating Tablet of Reglan (metoclopramide) is metabolized faster than the conventional Reglan tablet in patients with diabetic gastroparesis, pharmacokinetics following a single 10 mg dose of each formulation are being compared. Subjects must be 18 or older, have Type 1 or 2 diabetes with documented gastroparesis and agree to withhold medications for gastroparesis for 3 days prior to each dosing. Exclusion criteria include serum glucose >300 mg/dL, Hb1Ac >10%, and concurrent illness interfering with gastrointestinal motility. Subjects will stay in the clinic overnight, and pharmacokinetic sampling will continue for 8 hours after the first morning dose. The time (Tmax) and amount (Cmax) of peak concentration and the area under the curve (AUC) from time zero to 8 hr will be compared for the 2 formulations.

Intravenous Ketorolac and Metoclopramide for Pediatric Migraine in the Emergency Department [Not yet recruiting]
Migraine headaches are a common problem for children. When treatment at home fails, children may benefit from intravenous treatment administered in a hospital setting like the Emergency Department. Most treatments used however have only been tested in adults and the best treatment strategy for children is not always clear. The combination of more than one medication is frequently prescribed in Canadian Emergency Departments. The purpose of this study is to investigate whether the combination of ketorolac (an anti-inflammatory pain medication) and metoclopramide (an anti-nauseant that may also relieve migraine headaches) is better than metoclopramide by itself.

Pharmacogenetic Factors and Side Effects of Metoclopramide and Diphenhydramine [Recruiting]

Comparison of Metoclopramide and Ibuprofen for the Treatment of Acute Mountain Sickness [Not yet recruiting]
The objective of this study is to determine the efficacy of metoclopramide in relieving the symptoms of Acute Mountain Sickness (AMS).

It is our hypothesis that the combined antiemetic and analgesic effects of metoclopramide (which has been study-proven to be effective in relieving symptoms of migraine headache) will prove to be more efficacious in relieving symptoms of acute mountain sickness than the standard, previously-studied analgesic medication, ibuprofen.

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Reports of Suspected Reglan (Metoclopramide) Side Effects

Tardive Dyskinesia (2700)Extrapyramidal Disorder (1952)Dystonia (1808)Unevaluable Event (158)Condition Aggravated (101)Akathisia (99)Tremor (93)Nervous System Disorder (87)Restless Legs Syndrome (68)Drug Interaction (65)more >>


PATIENT REVIEWS / RATINGS / COMMENTS

Based on a total of 4 ratings/reviews, Reglan has an overall score of 4. The effectiveness score is 4.50 and the side effect score is 8.50. The scores are on ten point scale: 10 - best, 1 - worst. Below are selected reviews: the highest, the median and the lowest rated.
 

Reglan review by 50 year old female patient

  Rating
Overall rating:  
Effectiveness:   Highly Effective
Side effects:   No Side Effects
  
Treatment Info
Condition / reason:   delayed gastric emptying-nausea
Dosage & duration:   5 mg taken daily for the period of couple years
Other conditions:   none
Other drugs taken:   none
  
Reported Results
Benefits:   It worked great! I would not be nauseated at all and could eat and have energy all day.
Side effects:   none, but the doc stopped it as I started needing it less, aid there would be too much risk of weird symptoms. I still miss it and wish I could have it back. But I am not as sick or as often I was. It was just stress and a job change helped also.
Comments:   I took in the am when nauseated, I would take again if needed but after a while it worked all day for me. I took as little as possible as I am not a big pill taker

 

Reglan review by 61 year old female patient

  Rating
Overall rating:  
Effectiveness:   Ineffective
Side effects:   Severe Side Effects
  
Treatment Info
Condition / reason:   nausea
Dosage & duration:   unknown (dosage frequency: 2-3 times a day) for the period of 1 week
Other conditions:   abdominal surgery
Other drugs taken:   Cipro, Prednisone, Norvasc, lisinopril, Levoxyl
  
Reported Results
Benefits:   Their were no benefits, after discharge, 2days later I ended up in an emergency room. I was allergic to the cipro which was causing the nausea and had a very bad adverse reaction to the Reglan. The emergency room doctor stopped them both & placed me on other drugs.
Side effects:   I was extremely hyper, couldn't sit still, felt like I wanted to crawl out of my skin.
Comments:   Had abdominal surgery for diverticulitis, during procedure a hole was riped in the bowel. I was placed on a number of IV antibiotics, I was nausea the full 10 days in the hospital so 2 days before discharge they pt me on Reglan.

 

Reglan review by 61 year old female patient

  Rating
Overall rating:  
Effectiveness:   Ineffective
Side effects:   Severe Side Effects
  
Treatment Info
Condition / reason:   nausea
Dosage & duration:   unknown (dosage frequency: 2-3 times a day) for the period of 1 week
Other conditions:   abdominal surgery
Other drugs taken:   Cipro, Prednisone, Norvasc, lisinopril, Levoxyl
  
Reported Results
Benefits:   Their were no benefits, after discharge, 2days later I ended up in an emergency room. I was allergic to the cipro which was causing the nausea and had a very bad adverse reaction to the Reglan. The emergency room doctor stopped them both & placed me on other drugs.
Side effects:   I was extremely hyper, couldn't sit still, felt like I wanted to crawl out of my skin.
Comments:   Had abdominal surgery for diverticulitis, during procedure a hole was riped in the bowel. I was placed on a number of IV antibiotics, I was nausea the full 10 days in the hospital so 2 days before discharge they pt me on Reglan.

See all Reglan reviews / ratings >>

Page last updated: 2011-12-09

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