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Refludan (Lepirudin) - Published Studies


Refludan Related Published Studies

Well-designed clinical trials related to Refludan (Lepirudin)

Point of care measurement of lepirudin and heparin anticoagulation during systemic inflammation. [2002.10.01]

Lepirudin blunts endotoxin-induced coagulation activation. [2000.03.01]

Recombinant hirudin (lepirudin) for the improvement of thrombolysis with streptokinase in patients with acute myocardial infarction: results of the HIT-4 trial. [1999.10]

Well-designed clinical trials possibly related to Refludan (Lepirudin)

Recombinant hirudin for cardiopulmonary bypass anticoagulation: a randomized, prospective, and heparin-controlled pilot study. [2007.06]

Additive effects between platelet concentrates and desmopressin in antagonizing the platelet glycoprotein IIb/IIIa inhibitor eptifibatide. [2005.03]

Marked increase in vascular endothelial growth factor concentrations during Escherichia coli endotoxin-induced acute inflammation in humans. [2003.09]

Effects of anticoagulation on thrombopoietin release during endotoxemia. [2001.01]

Design, baseline characteristics, and preliminary clinical results of the Organization to Assess Strategies for Ischemic Syndromes-2 (OASIS-2) trial. [1999.09.02]

Recombinant hirudin (HBW 023) prevents troponin T release after coronary angioplasty in patients with unstable angina. [1995.12]

Other research related to Refludan (Lepirudin)

Lepirudin as an alternative to "heparin allergy" during cardiopulmonary bypass. [2011.04.08]

Alteration of pharmacokinetics of lepirudin caused by anti-lepirudin antibodies occurring after long-term subcutaneous treatment in a patient with recurrent VTE due to Behcets disease. [2010.02]

Use of subcutaneous lepirudin in an obese surgical intensive care unit patient with heparin resistance. [2009.10]

Lepirudin-induced thrombocytopenia following subcutaneous administration. [2009.05.01]

Lepirudin treatment in a girl with iliac vein thrombosis, severe pulmonary embolism and suspected heparin-induced thrombocytopenia (HIT) II. [2009.05]

Lepirudin treatment in a boy with suspected HIT II after surgery because of tetralogy of Fallot. [2009.05]

Dosing lepirudin in patients with heparin-induced thrombocytopenia and normal or impaired renal function: a single-center experience with 68 patients. [2009.03.12]

Lepirudin for treatment of acute thrombosis during pregnancy. [2008.08]

Lepirudin in the management of heparin-induced thrombocytopenia. [2008.08]

The use of ecarin chromogenic assay and prothrombinase induced clotting time in the monitoring of lepirudin for the treatment of heparin-induced thrombocytopenia. [2008.07]

Lepirudin for anticoagulation in patients with heparin-induced thrombocytopenia treated with continuous renal replacement therapy. [2007.05]

Severe anaphylactic reaction after repeated intermittent exposure to lepirudin. [2007.05]

Impact of smart infusion technology on administration of anticoagulants (unfractionated Heparin, Argatroban, Lepirudin, and Bivalirudin). [2007.04.01]

Salvage late plasmapheresis in a patient with pulmonary embolism caused by heparin-induced thrombocytopenia primarily resistant to danaparoid sodium and lepirudin. [2006.12]

[Treatment by lepirudin and acenocoumarol of heparin induced thrombocytopenia after valvular surgery: a word of caution] [2006.11]

Predictive factors for thrombosis and major bleeding in an observational study in 181 patients with heparin-induced thrombocytopenia treated with lepirudin. [2006.09.01]

Use of heparin versus lepirudin flushes to prevent withdrawal occlusion of central venous access devices. [2006.09]

Heparin- induced thrombocytopenia occurring in the first trimester of pregnancy: successful treatment with lepirudin. A case report. [2006.08]

Argatroban, bivalirudin, and lepirudin do not decrease clot propagation and strength as effectively as heparin-activated antithrombin in vitro. [2006.06]

Lepirudin anticoagulation for heparin-induced thrombocytopenia after cardiac surgery in a pediatric patient. [2006.05]

Recombinant factor VIIa for refractory bleeding after cardiac surgery secondary to anticoagulation with the direct thrombin inhibitor lepirudin. [2006.04]

Lepirudin for cardiopulmonary bypass surgery in a patient with terminal renal insufficiency and acute heparin-induced thrombocytopenia. [2006.03]

[A case of heparin induced thrombocytopenia treated with lepirudin infusion: case report] [2006]

Evaluation of diagnostic tests and argatroban or lepirudin therapy in patients with suspected heparin-induced thrombocytopenia. [2005.12]

Lepirudin in patients with heparin-induced thrombocytopenia - results of the third prospective study (HAT-3) and a combined analysis of HAT-1, HAT-2, and HAT-3. [2005.11]

Argatroban and lepirudin requirements in a 6-year-old patient with heparin-induced thrombocytopenia. [2005.10]

A comparison of lepirudin and argatroban outcomes. [2005.10]

Extracorporeal membrane oxygenation with lepirudin anticoagulation for Wegener's granulomatosis with heparin-induced thrombocytopenia. [2005.07]

Bidirectional glenn shunt surgery using lepirudin anticoagulation in an infant with heparin-induced thrombocytopenia with thrombosis. [2005.07]

Risk of anaphylaxis after reexposure to intravenous lepirudin in patients with current or past heparin-induced thrombocytopenia. [2005.04]

Treatment of patients with a history of heparin-induced thrombocytopenia and anti-lepirudin antibodies with argatroban. [2005.02]

Excessive anticoagulation and anaphylactic reaction after rechallenge with lepirudin in a patient with heparin-induced thrombocytopenia. [2004.12]

Lepirudin for prophylaxis of thrombosis in patients with acute isolated heparin-induced thrombocytopenia: an analysis of 3 prospective studies. [2004.11.15]

Lepirudin: a bivalent direct thrombin inhibitor for anticoagulation therapy. [2004.05]

[Lepirudin for therapeutic use in heparin-induced thrombocytopenia] [2004.05]

Lepirudin in heparin-induced thrombocytopenia and extracorporeal membranous oxygenation. [2004.04]

Retention of lepirudin at the tip of a silicone catheter: a better catheter flush solution? [2004.04]

Early onset of heparin-induced thrombocytopenia with thrombosis after open heart surgery: importance of an early diagnosis and Lepirudin treatment. [2004.03]

Antibodies against lepirudin are polyspecific and recognize epitopes on bivalirudin. [2004.01.15]

Characterization of the postglomerular renal metabolism of lepirudin in healthy volunteers. [2004]

Use of lepirudin during percutaneous vascular interventions in patients with heparin-induced thrombocytopenia. [2003.11]

Anaphylactic and anaphylactoid reactions associated with lepirudin in patients with heparin-induced thrombocytopenia. [2003.10.28]

Management of lepirudin therapy for a patient with antiphospholipid antibody syndrome using the whole blood ecarin clot time and activated partial thromboplastin time. [2003.09]

[Biventricular thrombi dissolution and antibody development with lepirudin therapy] [2003.07.11]

[Lepirudin during cardiopulmonary bypass in a patient with heparin-induced thrombocytopenia] [2003.07]

Massive pulmonary embolism due to late-onset heparin-induced thrombocytopenia following coronary artery bypass graft surgery: successful treatment with lepirudin. [2003.07]

Management of heparin-induced thrombocytopenia: a critical comparison of lepirudin and argatroban. [2003.05.01]

Lepirudin use in a neonate with heparin-induced thrombocytopenia. [2003.02]

Combination platelet glycoprotein IIb/IIIa receptor and lepirudin administration during percutaneous coronary intervention in patients with heparin-induced thrombocytopenia. [2003.01]

[Treatment with lepirudin in heparin-induced thrombocytopenia. A case report] [2002.12]

Outpatient management of venous thromboembolic disease with subcutaneous lepirudin: a case report. [2002.06]

Lepirudin anticoagulation for heparin-induced thrombocytopenia. [2002.02]

Arthus reaction to lepirudin, a new recombinant hirudin, and delayed-type hypersensitivity to several heparins and heparinoids, with tolerance to its intravenous administration. [2002.01]

Concurrent use of reteplase and lepirudin in the treatment of acute anterior wall myocardial infarction. [2001.10]

Use of lepirudin in patients with heparin-induced thrombocytopenia and renal failure requiring hemodialysis. [2001.07]

Lepirudin is a safe and effective anticoagulant for patients with heparin-associated antiplatelet antibodies. [2001.07]

A comparison of danaparoid and lepirudin in heparin-induced thrombocytopenia. [2001.06]

Use of ecarin clotting time (ECT) with lepirudin therapy in heparin-induced thrombocytopenia and cardiopulmonary bypass. [2001.05]

Lepirudin as a safe alternative for effective anticoagulation in patients with known heparin-induced thrombocytopenia undergoing percutaneous coronary intervention: case reports. [2001.04]

Recombinant hirudin in clinical practice: focus on lepirudin. [2001.03.13]

[Removal of lepirudin used as an anticoagulant in mechanical autotransfusion with Cell-Saver 5] [2001.03]

Trousseau's syndrome treated with long-term subcutaneous lepirudin (case report and review of the literature). [2001.02]

The use of lepirudin for anticoagulation in patients with heparin-induced thrombocytopenia during major vascular surgery. [2001.02]

Antihirudin antibodies in patients with heparin-induced thrombocytopenia treated with lepirudin: incidence, effects on aPTT, and clinical relevance. [2000.10.01]

Lepirudin dosing in dialysis-dependent renal failure. [2000.09]

Heparin-induced thrombocytopenia with thromboembolic complications: meta-analysis of 2 prospective trials to assess the value of parenteral treatment with lepirudin and its therapeutic aPTT range. [2000.08.01]

Continuous haemofiltration with r-hirudin (lepirudin) as anticoagulant in a patient with heparin induced thrombocytopenia (HIT II). [2000.06.16]

[R-hirudin (lepirudin, refludan) as an alternative anticoagulant in heparin-induced thrombocytopenia during cardiopulmonary bypass connection] [2000.06.10]

Recombinant hirudin (lepirudin) as anticoagulant in intensive care patients treated with continuous hemodialysis. [1999.11]

Lepirudin (recombinant hirudin) for parenteral anticoagulation in patients with heparin-induced thrombocytopenia. Heparin-Associated Thrombocytopenia Study (HAT) investigators. [1999.08.10]

[Heparin-induced thrombocytopenia type II with early aortocoronary bypass occlusion and stent thrombosis after PTCA of the RCA--treatment with lepirudin (Refludan) and abciximab (Reo pro) during recanalization of the RCA] [1999.02]

Recombinant hirudin (lepirudin) provides safe and effective anticoagulation in patients with heparin-induced thrombocytopenia: a prospective study. [1999.01.05]

[Heparin-induced thrombocytopenia type II. Intra- and postoperative lepirudin treatment in acute ischemia of the extremities] [1998.10.09]

Atypical heparin-induced thrombocytopenia complicated by intracardiac thrombus, effectively treated with ultra-low-dose rt-PA lysis and recombinant hirudin (Lepirudin). [1998.04]

Other possibly related research studies

Heparin and other rapidly acting anticoagulants. [2005.09]

The paradox of heparin-induced thrombocytopenia: the initial management. [2005.06]

Clinical presentation and laboratory diagnosis of heparin-induced thrombocytopenia. [2005.03]

Pulmonary embolism after cesarian section due to heparin-induced thrombocytopenia despite normal platelet count. [2005.08]

[Direct Inhibition of Thrombin. A New Strategy for the Treatment of Atrial Fibrillation and Acute Coronary Syndrome?] [2005.05]

Heparin-induced thrombocytopenia: principles for early recognition and management. [2005.04]

An anesthesia provider's perspective of heparin-induced thrombocytopenia. [2005.04]

Delayed-onset heparin-induced thrombocytopenia. [2005.04]

[Use of ecarin clotting time in whole blood for monitoring recombinant hirudine treatment during cardiopulmonary bypass in patients with heparin-induced thrombocytopenia] [2005.03]

Transition to an oral anticoagulant in patients with heparin-induced thrombocytopenia. [2005.02]

The management of patients with heparin-induced thrombocytopenia who require anticoagulant therapy. [2005.02]

Successful use of recombinant hirudin and its monitoring by ecarin clotting time in patients with heparin-induced thrombocytopenia undergoing off-pump coronary artery revascularization. [2005.01]

Delayed thrombin generation with hirudin anticoagulation during prolonged cardiopulmonary bypass. [2005.01]

Incidence of heparin-induced thrombocytopenia and therapeutic strategies in pediatric cardiac surgery. [2005.01]

Alternatives to heparin infusion. [2004.11]

Heparin-induced thrombocytopenia presenting with thrombosis of multiple saphenous vein grafts and myocardial infarction. [2004.08]

The use of direct thrombin inhibitors in cardiovascular surgery in patients with heparin-induced thrombocytopenia. [2004.06]

Percutaneous interventions in patients with immune-mediated heparin-induced thrombocytopenia. [2004.06]

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