Media Articles Related to Raptiva (Efalizumab)
Study: Genes are responsible for why Caucasians are 10 times more likely to develop psoriasis than the Chinese
Source: Dermatology News From Medical News Today [2015.04.27]
A*STAR's Genome Institute of Singapore (GIS) led an international team of researchers from Singapore, China, USA and Europe to conduct the world's first large-scale, trans-ethnic, genome-wide...
Ingredient in MS, Psoriasis Drugs Linked to Two Deadly Brain Infections
Source: MedicineNet Psoriasis Specialty [2015.04.09]
Title: Ingredient in MS, Psoriasis Drugs Linked to Two Deadly Brain Infections
Category: Health News
Created: 4/8/2015 12:00:00 AM
Last Editorial Review: 4/9/2015 12:00:00 AM
Source: MedicineNet Actinic Keratosis Specialty [2015.03.31]
Category: Diseases and Conditions
Created: 12/31/1997 12:00:00 AM
Last Editorial Review: 3/31/2015 12:00:00 AM
Tough-to-Treat Psoriasis Responds to Anti-PDE4
Source: MedPage Today Allergy & Immunology [2015.03.25]
(MedPage Today) -- Response at 16 weeks maintained a full year in most cases.
Oral Otezla (apremilast) long-term safety and efficacy data in patients with moderate to severe plaque psoriasis presented
Source: Arthritis / Rheumatology News From Medical News Today [2015.03.24]
Celgene Corporation has announced that results from long-term efficacy and safety analyses of the ESTEEM phase III clinical trial program of Otezla® (apremilast) were presented at the 73rd...
Published Studies Related to Raptiva (Efalizumab)
A short cycle of narrow-band UVB phototherapy in the early phase of long-term efalizumab can provide a quicker remission of moderate and severe psoriasis: a pilot study. 
CONCLUSION: This pilot study indicates that the combination with NB-UVB improves the efficacy of efalizumab monotherapy in the treatment of moderate to severe psoriasis. Copyright 2009 S. Karger AG, Basel.
Effect of therapeutic integrin (CD11a) blockade with efalizumab on immune responses to model antigens in humans: results of a randomized, single blind study. [2008.11]
Efalizumab is a humanized monoclonal CD11a antibody approved for treatment of psoriasis. Its immunomodulatory effects led us study how immune responses are modified and the possible consequences for vaccinations in clinical practice... These results expand our knowledge of how immune responses are modulated in humans by CD11a blockade and have implications for vaccinations of patients treated with this agent.
Long-term efficacy of up to 15 months' efalizumab therapy in patients with moderate-to-severe chronic plaque psoriasis. [2008.11]
The efficacy and safety of efalizumab in the treatment of moderate-to-severe chronic psoriasis has been established in studies of up to 3 years' duration. This study aims to describe the efficacy of up to 15 months' treatment with efalizumab and the convenience of therapy in patients with moderate-to-severe chronic plaque psoriasis.
Subcutaneous efalizumab is not effective in the treatment of alopecia areata. [2008.03]
BACKGROUND: Alopecia areata (AA) is a T-cell-mediated autoimmune disease. Efalizumab is a T-cell-targeted therapy approved for the treatment of psoriasis. OBJECTIVE: To assess the efficacy and safety of efalizumab in the treatment of moderate-to-severe AA... CONCLUSION: A 3- to 6-month trial of efalizumab was not effective in promoting hair regrowth in this small cohort of patients with moderate-to-severe AA.
Safety of Efalizumab Therapy in Patients with Moderate to Severe Psoriasis: An Open-Label Extension of a Phase IIIb Trial. 
BACKGROUND: Psoriasis is a chronic autoimmune disease characterized by infiltration of the dermis and epidermis by activated T cells and the hyperproliferation and abnormal differentiation of keratinocytes. It is a life-long disease with alternating periods of remission and recurrence. Efalizumab is a humanized, recombinant, T-cell targeting monoclonal antibody, approved for use in adults with chronic moderate to severe plaque psoriasis. OBJECTIVE: To assess the safety of continued or newly initiated treatment with efalizumab for up to 48 weeks in patients with psoriasis who were treated previously with efalizumab or placebo... CONCLUSIONS: These results support the short-term safety profile demonstrated for efalizumab over a longer-term therapy period of up to 60 weeks.
Clinical Trials Related to Raptiva (Efalizumab)
Evaluate Whether Combination Therapy With Methotrexate and Raptiva in Psoriasis Patients is Safe and Increases Efficacy [Active, not recruiting]
To evaluate whether a short-term course of methotrexate in patients treated with efalizumab
(Raptiva) increases efficacy. The secondary objectives of this study are 1) to evaluate the
efficacy of Raptiva in maintaining the clinical improvement induced by short-term treatment
with combination therapy of Raptiva and methotrexate 2) to evaluate the safety of short-term
combination therapy of Raptiva and methotrexate.
Pilot Trial to Assess Effect of CNI Conversion of Efalizumab on T Reg Cells [Not yet recruiting]
The purpose of this pilot trial is to determine whether a conversion from calcineurin
inhibitors (CNI) and mycophenolate mofetil (MMF) to a regimen consisting of efalizumab and
sirolimus is associated with an increase in T regulatory cells, white cells that control the
immune system and can prevent autoimmune diseases like arthritis or rejection of foreign
organs,and does not result in an increase in acute rejection.
Discoid Lupus Erythematosus of the Scalp and a Trial of Biologic Therapy With Raptiva [Terminated]
The purpose of this study is to investigate the efficacy of Raptiva (efalizumab) in the
treatment of discoid lupus erythematosus (DLE). Discoid lupus erythematosus is a chronic
disorder, which may lead to permanent and progressive loss of hair. Lupus is a condition of
chronic inflammation cause by an autoimmune disease. Autoimmune diseases are illnesses which
occur when the body's tissues are attacked by its own immune system. The immune system is a
complex system within the body that is designed to fight infectious agents, for example,
bacteria, and other foreign invaders.
One of the mechanisms that the immune system uses to fight infections is the production of
antibodies. Patients with lupus produce abnormal antibodies in their blood that target
tissues within their own body rather than foreign infectious agents. Lupus can cause disease
of the skin, heart, lungs, kidneys, joints, and nervous system. When only the skin is
involved, the condition is called discoid lupus erythematosus (DLE).
Raptiva (efalizumab) is a humanized immunoglobulin(a protein extract from blood which fights
off infection-sometimes called "antibody"), which targets the immune cells that are activated
in inflammation. Raptiva has been approved for use in the management of psoriasis at doses
of 1mg/kg, but is not approved for the treatment of DLE.
A Study to Evaluate Raptiva in Adults With Plaque Psoriasis Previously Enrolled in Study ACD2390g [Completed]
This is an open-label, multicenter study designed to evaluate the efficacy and safety of
efalizumab administered at weekly SC (subcutaneous) doses of 1. 0 mg/kg followed by efalizumab
taper in subjects with plaque psoriasis who previously participated in Study ACD2390g.
Raptiva and Sirolimus in Islet Transplantation for Type 1 Diabetes [Recruiting]
The primary objective of this protocol is to test the safety and efficacy of a treatment
regimen consisting of maintenance therapy with efalizumab and sirolimus for 1 year followed
by withdrawal of efalizumab and maintenance therapy with sirolimus, for the prevention of the
destruction and rejection of islet transplants in type 1 diabetic recipients.
Reports of Suspected Raptiva (Efalizumab) Side Effects
Squamous Cell Carcinoma (2),
Lymphocyte Count Increased (1),
Skin Discolouration (1),
Upper Respiratory Tract Infection (1),
Oedema Peripheral (1),
Hearing Impaired (1),
Acute Myocardial Infarction (1), more >>