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Ranitidine (Ranitidine Hydrochloride) - Summary

 
 



RANITIDINE SUMMARY

Ranitidine hydrochloride (HCl) is a histamine H2-receptor antagonist.

Ranitidine tablets are indicated in:

  1. Short-term treatment of active duodenal ulcer. Most patients heal within 4 weeks. Studies available to date have not assessed the safety of ranitidine in uncomplicated duodenal ulcer for periods of more than 8 weeks.

  2. Maintenance therapy for duodenal ulcer patients at reduced dosage after healing of acute ulcers. No placebo-controlled comparative studies have been carried out for periods of longer than 1 year.

  3. The treatment of pathological hypersecretory conditions (e.g., Zollinger-Ellison syndrome and systemic mastocytosis).

  4. Short-term treatment of active, benign gastric ulcer. Most patients heal within 6 weeks and the usefulness of further treatment has not been demonstrated. Studies available to date have not assessed the safety of ranitidine in uncomplicated, benign gastric ulcer for periods of more than 6 weeks.

  5. Maintenance therapy for gastric ulcer patients at reduced dosage after healing of acute ulcers. Placebo-controlled studies have been carried out for 1 year.

  6. Treatment of GERD. Symptomatic relief commonly occurs within 24 hours after starting therapy with ranitidine 150 mg b.i.d.

  7. Treatment of endoscopically diagnosed erosive esophagitis. Symptomatic relief of heartburn commonly occurs within 24 hours of therapy initiation with ranitidine 150 mg q.i.d.

  8. Maintenance of healing of erosive esophagitis. Placebo-controlled trials have been carried out for 48 weeks.

Concomitant antacids should be given as needed for pain relief to patients with active duodenal ulcer; active, benign gastric ulcer; hypersecretory states; GERD; and erosive esophagitis.


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NEWS HIGHLIGHTS

Published Studies Related to Ranitidine

Onset of relief of symptoms of gastroesophageal reflux disease: post hoc analysis of two previously published studies comparing pantoprazole 20 mg once daily with nizatidine or ranitidine 150 mg twice daily. [2010.04]
BACKGROUND: Systematic assessments of the onset of symptom relief in the treatment of gastroesophageal reflux disease (GERD) are lacking. OBJECTIVE: This work evaluated the time interval until complete symptom relief from heartburn (including both daytime and nighttime heartburn) and acid regurgitation in patients with GERD or endoscopy-negative GERD (NERD) during the first 7 days of treatment with pantoprazole, nizatidine, or ranitidine... CONCLUSION: In this post hoc reanalysis of data from 2 previously published clinical trials, use of pantoprazole 20 mg once daily was associated with effective early relief from heartburn and acid regurgitation among these patients with GERD and NERD; relief occurred as fast as and, in some cases, even faster than that seen with nizatidine or ranitidine.

Onset of relief of symptoms of gastroesophageal reflux disease: post hoc analysis of two previously published studies comparing pantoprazole 20 mg once daily with nizatidine or ranitidine 150 mg twice daily. [2010]
first 7 days of treatment with pantoprazole, nizatidine, or ranitidine... CONCLUSION: In this post hoc reanalysis of data from 2 previously published

Ranitidine is unable to maintain gastric pH levels above 4 in septic patients. [2009.12]
PURPOSE: The study aimed to evaluate whether ranitidine and pantoprazole are able to maintain gastric pH >or=4 in septic patients... CONCLUSIONS: Intravenous ranitidine was unable to maintain gastric pH above 4 in septic patients. All cases in the ranitidine group in whom pH remained above 4 had gastric hypotrophy or atrophy. Pantoprazole successfully maintained pH levels above 4.

Nosocomial pneumonia risk and stress ulcer prophylaxis: a comparison of pantoprazole vs ranitidine in cardiothoracic surgery patients. [2009.08]
BACKGROUND: Stress ulcer prophylaxis (SUP) using ranitidine, a histamine H2 receptor antagonist, has been associated with an increased risk of ventilator-associated pneumonia. The proton pump inhibitor (PPI) pantoprazole is also commonly used for SUP. PPI use has been linked to an increased risk of community-acquired pneumonia. The objective of this study was to determine whether SUP with pantoprazole increases pneumonia risk compared with ranitidine in critically ill patients... CONCLUSION: The use of pantoprazole for SUP was associated with a higher risk of nosocomial pneumonia compared with ranitidine. This relationship warrants further study in a randomized controlled trial.

Performance of acidified 14C-urea capsule breath test during pantoprazole and ranitidine treatment. [2009.07]
BACKGROUND AND AIM: Urea breath test (UBT) results could be false negative in patients taking antisecretory drugs. This effect would be prevented by citric acid administration during UBT. We prospectively investigated whether acidified 14C-urea capsule prevents false negative UBT results in patients taking antisecretory drugs and show interference with the duration of medications... CONCLUSIONS: The use of acidified 14C-urea capsule did not prevent false negative UBT results in patients taking pantoprazole and ranitidine, and the duration of medication does not affect the test results.

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Clinical Trials Related to Ranitidine

Effect of Ranitidine on Hyper-IgE Recurrent Infection (Job's) Syndrome [Recruiting]
This study will examine the safety and effectiveness of ranitidine (Zantac) in patients with Hyper-IgE recurrent infection syndrome, a disease characterized by recurrent infections of the ears, sinuses, lungs and skin, and abnormal levels of the antibody immunoglobulin E (IgE).

Patients age 2 and older who have Hyper-IgE recurrent infection syndrome and who have had chronic or frequent infections in the last 12 months may be eligible for this study.

Participants are randomly assigned to take ranitidine or placebo in pill or liquid form twice a day for 12 months. In addition to treatment, patients undergo the following procedures during visits scheduled on day 0 of the study (baseline) and at 3, 12, 15 and 24 months. Evaluations at 6, 9, 18 and 21 months are by telephone.

- Medical history and physical examination - baseline and 3 and 24 months.

- Clinical severity score - baseline and 3, 6, 9, 12, 15, 18, 21 and 24 months.

- Dermatology exam - baseline and 3, 12, 15 and 24 months.

- Pulmonary function test - baseline and 12 and 24 months.

- Chest CT - baseline and 12 and 24 months.

- Quality of life assessment - baseline and 3, 12, 15 and 24 months.

- Pregnancy testing - baseline and 3, 12, 15 and 24 months.

- HIV test - baseline and 12 and 24 months.

- Contraception evaluation - baseline and 3, 6, 9, 12, 15, 18, 21 and 24 months.

- Missed school/work days assessment - baseline and 3, 12, 15 and 24 months.

- Medication adherence - baseline and 3, 6, 9, 12, 15, 18, 21 and 24 months.

In addition to the above procedures, participants who are not enrolled in study 00-I-0159 have a baseline scoliosis series and genetic consult....

Comparison of Pantoprazole and Ranitidine in Dyspepsia [Recruiting]
The H0 hypothesis of the study there is no difference between pantoprazole and ranitidine in treating patients presented with dyspepsia to the emergency deparment.

The H1 hypothesis is there is difference between pantoprazole and ranitidine in treating patients presented with dyspepsia to the emergency department.

A Study to Evaluate The Effects of Two Different Meal Types, Omeprazole And Ranitidine On Danoprevir Pharmacokinetics When Coadministered With Ritonavir in Healthy Volunteers [Recruiting]
This randomized, open-label study will evaluate the effect of food, and the effect of omeprazole and ranitidine on danoprevir co-administered with ritonavir. Volunteers will be assigned to one of two treatment groups. Volunteers in both groups will receive oral doses of danoprevir and ritonavir. In addition, volunteers in group 2 will receive oral doses of omeprazole and ranitidine. The anticipated time of the study is approximately 6 weeks.

A Comparative Efficacy and Safety Study of Nexium Delayed-Release Capsules (40mg qd and 20mg qd) Versus Ranitidine 150mg Bid for the Healing of NSAID-Associated Gastric Ulcers When Daily NSAID Use is Continued [Completed]
Nonsteroidal anti-inflammatory drugs (NSAIDS) are often associated with gastric ulcers. This study looks at the treatment of these gastric ulcers with one of the three following treatment groups: esomeprazole 40 mg once daily; esomeprazole 20 mg once daily; or ranitidine 150 mg twice daily.

A Study To Investigate The Effectiveness Of AH234844 (Lavoltidine) Compared With NEXIUM And Ranitidine. [Completed]
Current treatment for gastroesophageal reflux disease (GERD) confirms an unmet need in patients, based on slow onset of action and an inability to provide 24-hour gastric-acid suppression. Clinical data on AH234844 demonstrates a rapid onset of action, high potency, and prolonged duration of effect. The present study endeavors, in part, to compare lavoltidine to two GERD drugs, NEXIUM and ranitidine.

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Reports of Suspected Ranitidine Side Effects

Dyspnoea (67)Fatigue (51)Anaphylactic Reaction (41)Vomiting (36)Chest Discomfort (35)Abdominal Pain (30)Malaise (27)Urticaria (20)Headache (20)Chest Pain (18)more >>


PATIENT REVIEWS / RATINGS / COMMENTS

Based on a total of 5 ratings/reviews, Ranitidine has an overall score of 7.60. The effectiveness score is 7.60 and the side effect score is 10. The scores are on ten point scale: 10 - best, 1 - worst. Below are selected reviews: the highest, the median and the lowest rated.
 

Ranitidine review by 48 year old female patient

  Rating
Overall rating:  
Effectiveness:   Highly Effective
Side effects:   No Side Effects
  
Treatment Info
Condition / reason:   heartburn
Dosage & duration:   300mg taken as needed for the period of as needed- 3 years
Other conditions:   scleroderma CREST w/Sjogren's
Other drugs taken:   levoxyl, prevacid, hydrocodone
  
Reported Results
Benefits:   heartburn was usually decreased significately if not totally
Side effects:   none
Comments:   I get heartburn caused more from my condition than from food. There were times that I had "breakthrough" heartburn even after using prevacid. I generally don't even use the prevacid now. I do try to not eat things that will cause heartburn but I still get heartburn often. I take the ranitidine often, but not every time I have heartburn. There are some times when I will take one or two Tums to get a jumpstart against the burning.

 

Ranitidine review by 36 year old male patient

  Rating
Overall rating:  
Effectiveness:   Moderately Effective
Side effects:   No Side Effects
  
Treatment Info
Condition / reason:   heartburn
Dosage & duration:   20mg taken 2-3 pd for the period of permantly
Other conditions:   n/a
Other drugs taken:   n/a
  
Reported Results
Benefits:   to reduce acid production and stop acid reflux, the tablets are easy to swallow and moderately effective, their effectivity is diminished if reflux is already occuring.
Side effects:   there are no side effects
Comments:   take 2-3 times per day to aviod reflux acid. this is most effective prior to eating so take 30 minutes before eating or drinking alcohol will help to aviod heartburn

 

Ranitidine review by 34 year old female patient

  Rating
Overall rating:  
Effectiveness:   Marginally Effective
Side effects:   No Side Effects
  
Treatment Info
Condition / reason:   Rash
Dosage & duration:   150 mg taken bid for the period of 15 days
Other conditions:   N/A
Other drugs taken:   N/A
  
Reported Results
Benefits:   Decreased redness and bumpiness by day 6. I believe the benefits were associated with the prescribed medication. However, I was also using a histamine blocking topical cream during the course of treatment.
Side effects:   None noted
Comments:   Rash of unknown origin. Intense itching, redness, and bumpy texture beginning on neck and slowly migrating around to appendages. Took prescription described above, as recommended. On Day 6, I noticed decreased irritation associated with rash.

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Page last updated: 2013-02-10

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