The active component of QVAR 40 mcg Inhalation Aerosol and QVAR 80 mcg Inhalation Aerosol is beclomethasone dipropionate, USP, an anti-inflammatory corticosteroid having the chemical name 9-chloro-11β,17,21-trihydroxy-16β-methylpregna-1,4-diene-3,20-dione 17,21-dipropionate.
QVAR is indicated in the maintenance treatment of asthma as prophylactic therapy in patients 5 years of age and older. QVAR is also indicated for asthma patients who require systemic corticosteroid administration, where adding QVAR may reduce or eliminate the need for the systemic corticosteroids.
Beclomethasone dipropionate is NOT indicated for the relief of acute bronchospasm.
Media Articles Related to Qvar (Beclomethasone Inhalation)
FDA Expands Xolair to Younger Kids With Allergic Asthma
Source: Medscape Allergy & Clinical Immunology Headlines [2016.07.11]
Omalizumab is now indicated in children as young as age 6 years with uncontrolled moderate to severe persistent allergic asthma.
Increase in childhood and adult asthma linked to London's 1952 Great Smog
Source: Respiratory / Asthma News From Medical News Today [2016.07.11]
London's Great Smog of 1952 resulted in thousands of premature deaths and even more people becoming ill.
Certain red flags indicate an increased need for intensive care among patients with asthma
Source: Respiratory / Asthma News From Medical News Today [2016.07.04]
In patients admitted to the hospital for asthma, illicit drug use and low socioeconomic status were linked with an increased risk of requiring admission to the intensive care unit.
MicroRNAs identified as novel targets for treating asthma
Source: Respiratory / Asthma News From Medical News Today [2016.06.27]
A new study shows that microRNAs, which are small, noncoding RNA molecules that can silence genes, have an important role in inducing asthma.
What is Asthma? Asthma Myths Debunked
Source: MedicineNet Asthma Complexities Specialty [2016.06.24]
Title: What is Asthma? Asthma Myths Debunked
Created: 12/15/2008 12:00:00 AM
Last Editorial Review: 6/24/2016 12:00:00 AM
Published Studies Related to Qvar (Beclomethasone Inhalation)
Randomised clinical trial: preventive treatment with topical rectal beclomethasone dipropionate reduces post-radiation risk of bleeding in patients irradiated for prostate cancer. [2011.09]
BACKGROUND: Radiotherapy is an established treatment modality for prostate cancer; however, up to a third of patients develops a radiation-induced proctopathy. AIM: To assess the effect of topical beclomethasone dipropionate (BDP) in the prevention of radiation-induced proctopathy in patients undergoing radiotherapy for prostate cancer through a double-blind, placebo-controlled, randomised trial... CONCLUSIONS: Preventive treatment with topical rectal BDP during radiotherapy for prostate cancer significantly reduces the risk of rectal bleeding and radiation-induced mucosal changes and improves patient's quality of life, but does not influence other radiation-induced symptoms. (c) 2011 Blackwell Publishing Ltd.
Effect of Beclomethasone Nasal Spray on Intraocular Pressure in Ocular Hypertension or Controlled Glaucoma. [2011.06.28]
PURPOSE: To evaluate the effect of 6 weeks administration of beclomethasone nasal spray on intraocular pressure (IOP) in patients with ocular hypertension or controlled primary open-angle glaucoma... CONCLUSIONS: Patients with ocular hypertension and primary open-angle glaucoma showed no evidence of IOP elevation after 6 weeks use of beclomethasone nasal spray.
Beclomethasone dipropionate in Crohn's ileitis: a randomised, double-blind trial. [2011.06]
BACKGROUND: Steroids, the mainstay of Crohn's disease treatment, have been associated with systemic side effects. AIM: To evaluate the efficacy and tolerability of beclomethasone dipropionate for maintaining remission induced by a short course of systemic steroids in patients with Crohn's ileitis with or without right colonic involvement... CONCLUSION: These results demonstrate that beclomethasone dipropionate significantly reduces the relapse rate in post-active Crohn's ileitis patients compared with placebo after induction of remission with a short course of systemic steroids, and is well tolerated. Copyright (c) 2010 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.
Use of beclomethasone dipropionate as rescue treatment for children with mild persistent asthma (TREXA): a randomised, double-blind, placebo-controlled trial. [2011.02.19]
BACKGROUND: Daily inhaled corticosteroids are an effective treatment for mild persistent asthma, but some children have exacerbations even with good day-to-day control, and many discontinue treatment after becoming asymptomatic. We assessed the effectiveness of an inhaled corticosteroid (beclomethasone dipropionate) used as rescue treatment... INTERPRETATION: Children with mild persistent asthma should not be treated with rescue albuterol alone and the most effective treatment to prevent exacerbations is daily inhaled corticosteroids. Inhaled corticosteroids as rescue medication with albuterol might be an effective step-down strategy for children with well controlled, mild asthma because it is more effective at reducing exacerbations than is use of rescue albuterol alone. Use of daily inhaled corticosteroid treatment and related side-effects such as growth impairment can therefore be avoided. FUNDING: National Heart, Lung and Blood Institute. Copyright (c) 2011 Elsevier Ltd. All rights reserved.
Rapid onset of bronchodilation with formoterol/beclomethasone Modulite and formoterol/budesonide Turbuhaler as compared to formoterol alone in patients with COPD. [2011.02]
In the present study, we examined whether there is a difference in the onset of bronchodilatation between formoterol/beclomethasone 12/200 mug Modulite and formoterol/budesonide 9/320 mug Turbuhaler in patients with COPD. We enrolled 28 patients with stable COPD... This study confirms the rapid effect of the inhaled corticosteroid component when combined with formoterol and indicates that the onset of bronchodilation of formoterol/beclomethasone Modulite and formoterol/budesonide Turbuhaler are similar and greater than formoterol alone in patients with COPD.
Clinical Trials Related to Qvar (Beclomethasone Inhalation)
Effects of QVAR in Smokers With Asthma [Recruiting]
We hypothesize that extra-fine particle treatment with HFA-QVAR will be superior in
improving small airways dysfunction, especially in ex-smokers and smokers with asthma.
To investigate this, we will perform a study comparing the efficacy of extra-fine particle
HFA-QVAR 200 µg b. i.d. to an equipotent dose of course particle HFA-beclomethasone
(HFA-Clenil) 400 µg b. i.d. and with coarse particle HFA-fluticasone (GSK) 250 µg in
ex-smokers and smokers with asthma.
Study design: This study will be an open-label, randomised, three-way cross-over, two-center
study. 20 smokers and 20 ex-smokers with asthma will receive the following treatments for
Effect of Flovent Discus vs QVAR vs Pulmicort Flexhaler on Short Term Growth [Recruiting]
Children with mild persistent asthma that have asthma symptoms once or twice a week and use
a daily controller, while children with mild intermittent asthma rarely have asthma symptoms
and do not use a daily controller. Inhaled corticosteroids are the standard treatment for
mild peristent asthma. The purpose of this study is to measure children rate of growth
while on different inhaled corticosteroids.
Inhaled Extra-fine Hydrofluoalkane-beclomethasone (QVAR) in Premature Infants With Bronchopulmonary Dysplasia (BPD) [Recruiting]
Premature infants with chronic lung disease (bronchopulmonary dysplasia [BPD]) are commonly
treated with inhaled steroids, an optional treatment according to textbooks and guidelines .
However, the evidence supporting this treatment in spontaneously breathing infants is
limited, and based on only two randomized, placebo-controlled trials (RCT) with relative
small number of infants . The Cochrane review concluded that these studies do not allow firm
conclusions with regard to the efficacy of inhaled steroids in non-ventilated infants .
Thus, there is no doubt that there is a need for more RCT in order to ascertain the role of
inhaled steroids in infants with BPD. Because of its physical properties that theoretically
make QVAR an attractive therapy in infants and studies showing it to be as effective as and
with similar safety profile as other inhaled steroids in children, the investigators
hypothesized that inhaled QVAR will be an effective therapy in infants with BPD.
Sunovion Growth Study Pediatric Subjects With Mild Asthma & Allergic Rhinitis [Recruiting]
This study will provide the clinicians guidance on the safest combination of inhaled and
nasal corticosteroids for children with mild asthma and allergic rhinitis respectively;
however, one safety concern is that these products are independently known to have
dose-related effects on short term and intermediate term growth. Knemometry is a non
invasive technique for measuring short-term lower leg growth in children and is currently
the method of choice in growth studies of short duration. Subjects will be seen on a weekly
basis for 18 weeks and at each visit, lower leg length will be measured using knemometry.
The Effect of HFA - Beclomethasone Dipropionate Qvar on Bronchial Hyperreactivity in Preschool Children [Completed]
Respiratory diseases including Asthma are high prevalent among preschool children. Specific
treatment, nowadays, include steroid inhalers and anti leukotrienes. It is known that the
amount of the drug reaching small airways and lungs is bigger how much smaller the particles
liberated by inhalers. Beclometasone is being used for treating asthma for 30 years. Lately
emerged a new presentation of beclometasone, which liberates particles as small as 2. 1 µg,
that is supposed to reach the small airways at higher concentrations and be more suitable to
patients who don't cooperate properly to the procedure of inhalation.
The investigators' group has reported successfully the possibility to perform Pulmonary
Challenge tests (adenosine, methacholine and exercise) in tender age. Other studies reported
relation between asthma control and reduction in airway hyperreactivity. The purpose of this
study is to evaluate the efficacy of Beclometasone dipropionate - Qvar to reduce airways
hyperreactivity in preschool children, as demonstrated by adenosine challenge test.