Media Articles Related to Qutenza (Capsaicin)
Targeting nerve endings to curb allergic asthma
Source: Allergy News From Medical News Today [2015.06.26]
New treatment approach could break a vicious cycle of neuro-immune signalingFig 1 F/G: Activation of nociceptors, done for study purposes with a compound called capsaicin, promotes the...
Body's response to spicy foods guides design of new pain relief drugs
Source: Pain / Anesthetics News From Medical News Today [2015.06.10]
UC Davis researchers have identified the molecular interactions that allow capsaicin to activate the body's primary receptor for sensing heat and pain, paving the way for the design of more selective...
Osteopathic manipulative therapy significantly improves low back pain in postpartum women
Source: Bones / Orthopedics News From Medical News Today [2015.07.01]
German researchers found osteopathic manipulative therapy (OMTh) decreased postpartum low back pain by over 70 percent in women who had given birth at least three months before beginning treatment...
Aching Foot Makes OA-Related Knee Pain Worse (CME/CE)
Source: MedPage Today Neurology [2015.07.01]
(MedPage Today) -- Clinicians should consider evaluating the foot and ankle of osteoarthritis patients
Gender difference in pain transmission, reports new study
Source: Immune System / Vaccines News From Medical News Today [2015.06.30]
A mouse study has found that different immune cells in males and females are responsible for the transmission of pain, raising questions about human pain drug development.
Published Studies Related to Qutenza (Capsaicin)
Capsaicin 8% patch for treprostinil subcutaneous infusion site pain in pulmonary
hypertension patients. 
trepostinil-induced pain... CONCLUSIONS: Further investigation of the efficacy of capsaicin 8% patch in this
Diclofenac with or without an antiemetic for acute migraine headaches in adults. 
CONCLUSIONS: Oral diclofenac potassium 50 mg is an effective treatment
Topical capsaicin (low concentration) for chronic neuropathic pain in adults. 
CONCLUSIONS: There were insufficient data to draw any conclusions about
Capsaicin instillation for postoperative pain following total knee arthroplasty: a preliminary report of a randomized, double-blind, parallel-group, placebo-controlled, multicentre trial. [2011.12.01]
BACKGROUND: Pain following total knee arthroplasty (TKA) interferes with rehabilitation. Capsaicin applied in high concentration to nociceptors can cause relatively selective C-fibre desensitization for a period of weeks to months. Resultant long-lasting analgesia might facilitate rehabilitation. OBJECTIVE: The objective of this study was to determine if direct instillation of a high-concentration capsaicin preparation into the wound following TKA would provide pain relief, improve physical functioning and rehabilitation, and reduce opioid requirements... CONCLUSION: Despite having higher BMIs, patients in the capsaicin group achieved comparable or better pain scores with significantly less opioid use in the first 3 postoperative days. They also had less pruritus, which may have been a consequence of the opioid-sparing effect. The effects of capsaicin with respect to function, however, appeared to be longer lasting, with improved active ROM reported at 14 days.
A randomized, double-blind, parallel trial comparing capsaicin nasal spray with placebo in subjects with a significant component of nonallergic rhinitis. [2011.08]
OBJECTIVE: To investigate the efficacy and safety of ICX72 or Sinus Buster, a proprietary homeopathic preparation of Capsicum annum and Eucalyptol, versus placebo administered continuously over 2 weeks in subjects with a significant component of nonallergic rhinitis (NAR)... CONCLUSION: This is the first controlled trial demonstrating intranasal capsaicin, when used continuously over 2 weeks, rapidly and safely improves symptoms in rhinitis subjects with a significant NAR component. Copyright (c) 2011 American College of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.
Clinical Trials Related to Qutenza (Capsaicin)
Method of Pre-treatment for Application of QUTENZA Capsaicin 8% Patch [Recruiting]
The Summary of product characteristics (SmPC) for QUTENZA advises that topical anaesthetic
is applied prior to the application of QUTENZA. This is a multi-center, randomized,
assessor-blinded study which will investigate the use of an oral analgesic as an alternative
form of pre-treatment for QUTENZA.
Acute Response Capsaicin Flare Study [Recruiting]
Prior to administering PF-04427429 to patients we wish to increase the understanding of
functional effects associated with calcitonin gene related peptide (CGRP) pathways. This
study will examine whether it is possible for a single dose of PF-04427429 to acutely
attenuate a capsaicin induced flare response.
Safety and Effectiveness of Repeated Administration of QUTENZA Patches for Treatment of Pain Caused by Nerve Damage [Recruiting]
In this study all patients will be treated with the same medicine, the QUTENZA patch.
Subjects will receive up to 6 QUTENZA patch applications over 12 months.
Qutenza«-Remodulin« in Pulmonary Arterial Hypertension Patients [Recruiting]
The investigators hypothesise that pre-application of Qutenza« patches to the skin may
reduce pain at the site of Remodulin« SC infusion (sited 1 to 2 weeks later at the site of
Qutenza pre-application), in which case it would greatly improve the quality of life of the
patients, and enable many more to continue with this treatment. It may also provide new
information to support the use of Qutenza« patches for preventing and reducing pain produced
The present study will explore the efficacy of single applications of Qutenza┬« (capsaicin 8%
patch) in reducing site pain caused by continuous SC infusion of Remodulin┬«, in pulmonary
arterial hypertension patients, as assessed by changes in subjective pain rating score
and/or pain and sensory testing.
Trial to Evaluate the Efficacy of Topical Capsaicin to Reduce Pain and Improve Health-related Quality of Life in Adults With Chronic Myofascial Neck Pain [Not yet recruiting]
Chronic neck pain is a common condition that can negatively impact quality of life.
Substance P is one of the chemicals in the body that can transmit pain signals from
overloaded neck muscles to the brain. Topical capsaicin blocks the action of Substance P by
releasing, and subsequently depleting the body's store of Substance P in the nerves.
Topical capsaicin has been reported to be an effective therapy for a number of persistent
pain conditions including diabetic neuropathy, post-herpetic neuralgia, osteoarthritis,
rheumatoid arthritis, and post-mastectomy pain. This study will evaluate the efficacy of
topical capsaicin to reduce pain and improve health-related quality of life in adults with
chronic muscular neck pain.
Reports of Suspected Qutenza (Capsaicin) Side Effects
Application Site Pain (26),
Application Site Erythema (15),
Condition Aggravated (8),
Application Site Swelling (5),
Application Site Pruritus (5),
Application Site Vesicles (5), more >>