Quinidine (Quinidine Sulfate) - Description

DESCRIPTION

Quinidine is an antimalarial schizonticide and an antiarrhythmic agent with Class Ia activity; it is the d-isomer of quinine, and its molecular weight is 324.43. Quinidine sulfate is the sulfate salt of quinidine; its chemical name is cinchonan-9-ol, 6’-methoxy-, (9S)-, sulfate (2:1) (salt) dihydrate; its molecular weight is 782.94, of which 82.9% is quinidine base; and it has the following structural formula:

(C₂₀H₂₄N₂O₂)₂•H₂SO₄•2H₂O M.W. 782.94

Each Quinidine Sulfate Extended-release Tablet contains 300 mg of quinidine sulfate (249 mg of quinidine base) in a formulation to provide extended release; the inactive ingredients are: fumaric acid, hypromellose, lactose monohydrate, magnesium stearate, polydextrose, polyethylene glycol, povidone, triacetin and titanium dioxide.

These tablets comply with USP Drug Release Test 1.