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Quinaretic (Quinapril Hydrochloride / Hydrochlorothiazide) - Summary

 
 



BOXED WARNING

USE IN PREGNANCY

When used in pregnancy during the second and third trimesters, ACE inhibitors can cause injury and even death to the developing fetus. When pregnancy is detected, QUINARETIC should be discontinued as soon as possible. See WARNINGS: Fetal/Neonatal Morbidity and Mortality.

 

QUINARETIC SUMMARY

QUINARETIC is a fixed-combination tablet that combines an angiotensin-converting enzyme (ACE) inhibitor, quinapril hydrochloride, and a thiazide diuretic, hydrochlorothiazide.

QUINARETIC is indicated for the treatment of hypertension. This fixed combination is not indicated for the initial therapy of hypertension (see DOSAGE AND ADMINISTRATION).

In using QUINARETIC, consideration should be given to the fact that another angiotensin-converting enzyme inhibitor, captopril, has caused agranulocytosis, particularly in patients with renal impairment or collagen-vascular disease. Available data are insufficient to show that quinapril does not have a similar risk (see WARNINGS: Neutropenia/Agranulocytosis).

Angioedema in Black Patients:

Black patients receiving ACE inhibitor monotherapy have been reported to have a higher incidence of angioedema compared to non-blacks. It should also be noted that in controlled clinical trials, ACE inhibitors have an effect on blood pressure that is less in black patients than in non-blacks.


See all Quinaretic indications & dosage >>

NEWS HIGHLIGHTS

Media Articles Related to Quinaretic (Quinapril / Hydrochlorothiazide)

Isolated Systolic Hypertension in Young Adults Ups CVD Risk
Source: theheart.org | Medscape Cardiology Headlines [2015.01.30]
In younger and middle-aged adults, isolated systolic hypertension is not "benign," as many may have thought until now, new research shows.
Heartwire

New hypertension guidelines could save lives and money
Source: Hypertension News From Medical News Today [2015.01.30]
Increased treatment of severe hypertension particularly cost-effectiveFull implementation of new hypertension guidelines could prevent 56,000 cardiovascular disease events (mostly heart attacks...

Looser Hypertension Guidelines Could Still Save Lives, $$ (CME/CE)
Source: MedPage Today Cardiovascular [2015.01.30]
(MedPage Today) -- Even the less aggressive 2014 targets would be better than the status quo, study shows.

Alcohol Boosts Stroke Risk More Than Do Hypertension, Diabetes
Source: Medscape NeurologyHeadlines [2015.01.29]
Consuming more than two alcoholic drinks a day was a stronger predictor of stroke in early old age than were the traditional risk factors of hypertension or diabetes.
Medscape Medical News

Insomnia With Daytime Hyperarousal Linked to Hypertension
Source: Medscape NeurologyHeadlines [2015.01.29]
Researchers report further evidence that insomnia itself, without sleep apnea, is associated with the development of hypertension.
Medscape Medical News

more news >>

Clinical Trials Related to Quinaretic (Quinapril / Hydrochlorothiazide)

Atrial Substrate Modification With Aggressive Blood Pressure Lowering to Prevent AF [Recruiting]
Atrial fibrillation (AF) is a very common arrhythmia causing many symptoms resulting in numerous hospitalizations. Catheter ablation is a technique that has evolved significantly to improve symptomatic recurrences, but does not offer a 100% cure rate. We hypothesize that the use of aggressive BP lowering will reduce the rate of recurrent AF after catheter ablation for AF. We plan a randomized clinical trial of aggressive BP lowering versus standard BP control to investigate this. The primary outcome will be time to recurrent AF.

more trials >>


Page last updated: 2015-01-30

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