NEWS HIGHLIGHTSMedia Articles Related to Quibron-T (Theophylline)
Mom's Worrying Linked to Kid's Asthma (CME/CE)
Source: MedPageToday.com - medical news plus CME for physicians [2013.06.15]
(MedPage Today) -- Adolescents with asthma reported worse symptoms of breathlessness when they had anxious mothers, and the link may have more to do with genes than environment, researchers suggested.
Sleep May Ease Asthma in Teens (CME/CE)
Source: MedPage Today Allergy & Immunology [2013.06.03]
BALTIMORE (MedPage Today) -- A pilot sleep extension program for teens with asthma was associated with improved daytime lung function and fewer nighttime symptoms, researchers reported here.
Health Tip: Is Your Asthma Getting Worse?
Source: MedicineNet Asthma Specialty [2013.06.03]
Title: Health Tip: Is Your Asthma Getting Worse?
Category: Health News
Created: 6/3/2013 8:35:00 AM
Last Editorial Review: 6/3/2013 12:00:00 AM
Exercise-Induced Asthma Symptoms Reduced By Unique Omega-3 Supplement
Source: Respiratory / Asthma News From Medical News Today [2013.05.30]
An Indiana University study has found that a unique omega-3 supplement derived from the New Zealand green-lipped mussel significantly improved lung function and reduced airway inflammation in asthmatics who experience exercise-induced bronchoconstriction, also called exercise-induced asthma...
Common Childhood Asthma Unconnected To Allergens Or Inflammation
Source: Respiratory / Asthma News From Medical News Today [2013.05.27]
Little is known about why asthma develops, how it constricts the airway or why response to treatments varies between patients. Now, a team of researchers at Weill Cornell Medical College, Columbia University Medical Center and SUNY Downstate Medical Center has revealed the roots of a common type of childhood asthma, showing that it is very different from other asthma cases...
Published Studies Related to Quibron-T (Theophylline)
Beneficial effects of theophylline infusions in surgical patients with intra-abdominal hypertension. [2011.08]
BACKGROUND: Intra-abdominal hypertension (IAH) can cause high mortality. Recently, we found that IAH was associated with increased serum levels of adenosine and interleukin 10. Our present "hypothesis-generated study" was based on the above mentioned results... CONCLUSIONS: Adenosine receptor antagonism with T following IAH diagnosis resulted in markedly reduced mortality in patients with moderated IAH (<20 mmHg). Theophylline-associated mortality reduction may be related to improved renal perfusion and improved MAP, presumably caused by adenosine receptor blockade. Because this study was not a randomized controlled study, these compelling observations require further multicentric clinical confirmation.
Study investigating pharmacokinetic interaction between theophylline and roflumilast in healthy adults. [2011.07]
OBJECTIVE: To investigate whether a pharmacokinetic drug-drug interaction exists between theophylline (THEO), a CYP1A2 substrate with a narrow therapeutic index, and the concomitant substrate roflumilast (ROF), a novel selective PDE4 inhibitor partially metabolized by CYP1A2... CONCLUSIONS: Neither ROF nor its main metabolite had any impact on the metabolism of the concomitant CYP1A2 substrate THEO in humans. Though co-administration of THEO resulted in a minor increase (28%) in total ROF exposure, no safety or tolerability concerns and no altered total PDE4 inhibition of both ROF and R-NO, were observed.
Prevention of contrast-induced acute kidney injury by theophylline in elderly patients with chronic kidney disease. [2010.11]
Although the optimal strategy for preventing contrast-induced acute kidney injury (CI-AKI) has not yet been established, the current strategy focuses on adequate periprocedural hydration, the use of a low amount of low or iso-osmolar contrast medium, and the application of adjunctive therapies, including hemofiltration, hemodialysis and drugs...
Prevention of contrast-induced acute kidney injury by theophylline in elderly patients with chronic kidney disease. [2010.09.29]
Although the optimal strategy for preventing contrast-induced acute kidney injury (CI-AKI) has not yet been established, the current strategy focuses on adequate periprocedural hydration, the use of a low amount of low or iso-osmolar contrast medium, and the application of adjunctive therapies, including hemofiltration, hemodialysis and drugs...
Adenosine receptor inhibition with theophylline attenuates the skin blood flow response to local heating in humans. [2010.09]
Mechanisms underlying the robust cutaneous vasodilatation in response to local heating of human skin remain unresolved. Adenosine receptor activation has been shown to induce vasodilatation via nitric oxide, and a substantial portion of the plateau phase to local heating of human skin has been shown to be dependent on nitric oxide...
Clinical Trials Related to Quibron-T (Theophylline)
Rosiglitazone Versus Theophylline in Asthmatic Smokers [Completed]
Asthmatic smokers display a blunted response to both inhaled and oral corticosteroid
treatments and are at increased risk for exacerbations and near fatal asthma. The prevalence
of smoking in asthmatics runs between 20-30%. Therefore, new, more efficacious treatments are
required.
Recent work has demonstrated a mechanism which may explain steroid resistance. A commonly
used drug called theophylline can reverse this steroid resistance in laboratory studies.
Another commonly used drug, rosiglitazone can reverse smoking induced lung inflammation in
laboratory studies.
The investigators aim to study the effects of these drugs on smoking asthmatics' lung
function and other parameters including quality of life and asthma control.
All-trans Retinoic Acid, and Arsenic +/- Gemtuzumab [Recruiting]
The goal of this clinical research study is to learn if the combination of arsenic trioxide
(ATO) with ATRA and possibly idarubicin is effective in treating patients with
newly-diagnosed APL.
Theophylline in Chronic Obstructive Pulmonary Disease [Recruiting]
This will be a prospective randomized double-blinded parallel group clinical trial
evaluating the short-term effects of theophylline therapy on exercise duration and lung
function in patients with chronic obstructive pulmonary disease already receiving both
tiotropium and a long-acting beta-agonist (salmeterol or formoterol).
Theophylline in Treating Cancer Patients With Shortness of Breath [Active, not recruiting]
RATIONALE: Theophylline may help to relieve shortness of breath in patients who have cancer.
It is not yet known whether theophylline is more effective than no further treatment for
shortness of breath.
PURPOSE: Randomized phase III trial to determine the effectiveness of theophylline in
treating shortness of breath in patients who have cancer.
Theophylline in Treating Patients With In Situ, Stage I, or Stage II Chronic Lymphocytic Leukemia [Completed]
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing
so they stop growing or die.
PURPOSE: Phase II trial to study the effectiveness of theophylline in treating patients who
have in situ, stage I, or stage II chronic lymphocytic leukemia.
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