NEWS HIGHLIGHTSMedia Articles Related to Quibron T / SR (Theophylline)
Health Tip: Exercise With Allergies and Asthma
Source: MedicineNet Allergy Specialty [2013.05.15]
Title: Health Tip: Exercise With Allergies and Asthma
Category: Health News
Created: 5/15/2013 8:35:00 AM
Last Editorial Review: 5/15/2013 12:00:00 AM
Immunotherapy Effective in Pediatric Asthma and Rhinitis
Source: Medscape Allergy & Clinical Immunology Headlines [2013.05.13]
Subcutaneous and sublingual immunotherapy are both helpful for kids with asthma and rhinitis - and the sublingual approach has some advantages, although it doesn't have regulatory approval.
Reuters Health Information
Antifungal Therapy Could Benefit Nearly 5 Million Asthmatics Worldwide
Source: Allergy News From Medical News Today [2013.05.11]
An estimated 4,837,000 asthmatics with allergic bronchopulmonary aspergillosis (ABPA) could benefit substantially from antifungal treatment, say researchers from the University of Toronto and Manchester University. Their work, published in the journal Medical Mycology, has also re-estimated the total number of asthmatics worldwide - to reveal a staggering 193 million sufferers...
Needle-Free Relief For Children From Asthma And Allergies
Source: Allergy News From Medical News Today [2013.05.09]
Allergy shots are commonly used to treat children with severe environmental allergies and asthma, but under-the-tongue drops may offer yet another beneficial - and stick-free - option for pediatric allergy sufferers, according to a Johns Hopkins Children's Center review of existing scientific evidence...
How A Text Message A Day Can Keep The Asthma Attack Away
Source: Respiratory / Asthma News From Medical News Today [2013.05.02]
Simply sending children with asthma a text message each day asking about their symptoms and providing knowledge about their condition can lead to improved health outcomes...
Published Studies Related to Quibron T / SR (Theophylline)
Beneficial effects of theophylline infusions in surgical patients with intra-abdominal hypertension. [2011.08]
BACKGROUND: Intra-abdominal hypertension (IAH) can cause high mortality. Recently, we found that IAH was associated with increased serum levels of adenosine and interleukin 10. Our present "hypothesis-generated study" was based on the above mentioned results... CONCLUSIONS: Adenosine receptor antagonism with T following IAH diagnosis resulted in markedly reduced mortality in patients with moderated IAH (<20 mmHg). Theophylline-associated mortality reduction may be related to improved renal perfusion and improved MAP, presumably caused by adenosine receptor blockade. Because this study was not a randomized controlled study, these compelling observations require further multicentric clinical confirmation.
Study investigating pharmacokinetic interaction between theophylline and roflumilast in healthy adults. [2011.07]
OBJECTIVE: To investigate whether a pharmacokinetic drug-drug interaction exists between theophylline (THEO), a CYP1A2 substrate with a narrow therapeutic index, and the concomitant substrate roflumilast (ROF), a novel selective PDE4 inhibitor partially metabolized by CYP1A2... CONCLUSIONS: Neither ROF nor its main metabolite had any impact on the metabolism of the concomitant CYP1A2 substrate THEO in humans. Though co-administration of THEO resulted in a minor increase (28%) in total ROF exposure, no safety or tolerability concerns and no altered total PDE4 inhibition of both ROF and R-NO, were observed.
Prevention of contrast-induced acute kidney injury by theophylline in elderly patients with chronic kidney disease. [2010.11]
Although the optimal strategy for preventing contrast-induced acute kidney injury (CI-AKI) has not yet been established, the current strategy focuses on adequate periprocedural hydration, the use of a low amount of low or iso-osmolar contrast medium, and the application of adjunctive therapies, including hemofiltration, hemodialysis and drugs...
Prevention of contrast-induced acute kidney injury by theophylline in elderly patients with chronic kidney disease. [2010.09.29]
Although the optimal strategy for preventing contrast-induced acute kidney injury (CI-AKI) has not yet been established, the current strategy focuses on adequate periprocedural hydration, the use of a low amount of low or iso-osmolar contrast medium, and the application of adjunctive therapies, including hemofiltration, hemodialysis and drugs...
Adenosine receptor inhibition with theophylline attenuates the skin blood flow response to local heating in humans. [2010.09]
Mechanisms underlying the robust cutaneous vasodilatation in response to local heating of human skin remain unresolved. Adenosine receptor activation has been shown to induce vasodilatation via nitric oxide, and a substantial portion of the plateau phase to local heating of human skin has been shown to be dependent on nitric oxide...
Clinical Trials Related to Quibron T / SR (Theophylline)
Rosiglitazone Versus Theophylline in Asthmatic Smokers [Completed]
Asthmatic smokers display a blunted response to both inhaled and oral corticosteroid
treatments and are at increased risk for exacerbations and near fatal asthma. The prevalence
of smoking in asthmatics runs between 20-30%. Therefore, new, more efficacious treatments are
required.
Recent work has demonstrated a mechanism which may explain steroid resistance. A commonly
used drug called theophylline can reverse this steroid resistance in laboratory studies.
Another commonly used drug, rosiglitazone can reverse smoking induced lung inflammation in
laboratory studies.
The investigators aim to study the effects of these drugs on smoking asthmatics' lung
function and other parameters including quality of life and asthma control.
The Effect of Theophylline in the Treatment of Bronchiectasis [Recruiting]
Theophylline was well recommended in the treatment of COPD and asthma. However, there is no
supporting evidence for their efficacy in the treatment of bronchiectasis. Our hypothesis is
that theophylline will play a role in bronchiectasis. Our purpose is to examine the efficacy
and safety of 24 weeks treatment with theophylline in subjects with non-cystic fibrosis
bronchiectasis.
The Role of Theophylline Plus Low-dose Formoterol-budesonide in Treatment of Bronchiectasis [Not yet recruiting]
The purpose of this study is to examine the efficacy and safety of 24 weeks treatment with
theophylline plus low-dose formoterol-budesonide in subjects with bronchiectasis.
Theophylline in Chronic Obstructive Pulmonary Disease [Recruiting]
This will be a prospective randomized double-blinded parallel group clinical trial
evaluating the short-term effects of theophylline therapy on exercise duration and lung
function in patients with chronic obstructive pulmonary disease already receiving both
tiotropium and a long-acting beta-agonist (salmeterol or formoterol).
Acetylcysteine, Theophylline, and a Combination of Both in the Prophylaxis of Contrast-Induced Nephropathy [Completed]
Several studies demonstrated a significant reduction of contrast-induced nephropathy (CIN;
definition: increase in serum creatinine of >=0. 5mg/dl and/or >=25% increase within 48h after
contrast-medium) by acetylcysteine (A) or theophylline (T). However, the results are
contradictory. Therefore, it was the aim of our double-blind study to compare the effects of
A, T, a combination of A and T (A+T), and placebo (P).
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