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Qualaquin (Quinine Sulfate) - Side Effects and Adverse Reactions




Quinine can adversely affect almost every body system. The most common adverse events associated with quinine use are a cluster of symptoms called "cinchonism", which occurs to some degree in almost all patients taking quinine. Symptoms of mild cinchonism include headache, vasodilation and sweating, nausea, tinnitus, hearing impairment, vertigo or dizziness, blurred vision, and disturbance in color perception. More severe symptoms of cinchonism are vomiting, diarrhea, abdominal pain, deafness, blindness, and disturbances in cardiac rhythm or conduction. Most symptoms of cinchonism are reversible and resolve with discontinuation of quinine.

The following ADVERSE REACTIONS have been reported with quinine sulfate. Most of these reactions are thought to be uncommon, but the actual incidence is unknown:

General: fever, chills, sweating, flushing, asthenia, lupus-like syndrome, and hypersensitivity reactions.

Hematologic: agranulocytosis, hypoprothrombinemia, thrombocytopenia, disseminated intravascular coagulation, hemolytic anemia; hemolytic uremic syndrome, thrombotic thrombocytopenic purpura, idiopathic thrombocytopenic purpura, petechiae, ecchymosis, hemorrhage, coagulopathy, blackwater fever, leukopenia, neutropenia, pancytopenia, aplastic anemia, and lupus anticoagulant.

Neuropsychiatric: headache, diplopia, confusion, altered mental status, seizures, coma, disorientation, tremors, restlessness, ataxia, acute dystonic reaction, aphasia, and suicide.

Dermatologic: cutaneous rashes, including urticarial, papular, or scarlatinal rashes, pruritus, bullous dermatitis, exfoliative dermatitis, erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis, fixed drug eruption, photosensitivity reactions, allergic contact dermatitis, acral necrosis, and cutaneous vasculitis.

Respiratory: asthma, dyspnea, pulmonary edema.

Cardiovascular: chest pain, vasodilatation, hypotension, postural hypotension, tachycardia, bradycardia, palpitations, syncope, atrioventricular block, atrial fibrillation, irregular rhythm, unifocal premature ventricular contractions, nodal escape beats, U waves, QT prolongation, ventricular fibrillation, ventricular tachycardia, torsades de pointes, and cardiac arrest.

Gastrointestinal: nausea, vomiting, diarrhea, abdominal pain, gastric irritation, and esophagitis.

Hepatobiliary: granulomatous hepatitis, hepatitis, jaundice, and abnormal liver function tests.

Metabolic: hypoglycemia and anorexia.

Musculoskeletal: myalgias and muscle weakness.

Renal: hemoglobinuria, renal failure, renal impairment, and acute interstitial nephritis.

Special Senses: visual disturbances, including blurred vision with scotomata, sudden loss of vision, photophobia, diplopia, night blindness, diminished visual fields, fixed pupillary dilatation, disturbed color vision, optic neuritis, blindness, vertigo, tinnitus, hearing impairment, and deafness.


Below is a sample of reports where side effects / adverse reactions may be related to Qualaquin. The information is not vetted and should not be considered as verified clinical evidence.

Possible Qualaquin side effects / adverse reactions in 67 year old male

Reported by a consumer/non-health professional from United States on 2011-10-07

Patient: 67 year old male weighing 70.4 kg (154.8 pounds)

Reactions: OFF Label USE, Diarrhoea

Suspect drug(s):

Other drugs received by patient: Simvastatin; Vitamin D; Allegra

Possible Qualaquin side effects / adverse reactions in 49 year old female

Reported by a pharmacist from United States on 2011-12-30

Patient: 49 year old female weighing 56.7 kg (124.7 pounds)

Reactions: Hypoacusis, Tinnitus, Deafness

Suspect drug(s):
    Dosage: 250 mg (250 mg, 1 in 1 d), oral
    Administration route: Oral
    Indication: Infection Parasitic
    Start date: 2011-08-29
    End date: 2011-09-06

    Dosage: 1800 mg (300 mg, 2 in 8 hr), oral
    Administration route: Oral
    Indication: Infection Parasitic
    Start date: 2011-09-02

    Dosage: 1944 mg (324 mg, 2 in 8 hr)
    Indication: Infection Parasitic
    Start date: 2011-09-07
    End date: 2011-09-08

Other drugs received by patient: Levothyroxine Sodium; Atenolol

See index of all Qualaquin side effect reports >>

Drug label data at the top of this Page last updated: 2013-04-23

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