Qualaquin Related Published Studies
Well-designed clinical trials related to Qualaquin (Quinine)
Quinine-induced thrombocytopenia: drug-dependent GPIb/IX antibodies inhibit megakaryocyte and proplatelet production in vitro. [2011.06.02]
Limited ability of Plasmodium falciparum pfcrt, pfmdr1, and pfnhe1 polymorphisms to predict quinine in vitro sensitivity or clinical effectiveness in Uganda. [2011.02]
Artesunate versus quinine in the treatment of severe falciparum malaria in African children (AQUAMAT): an open-label, randomised trial. [2010.11.13]
Efficacy and safety of artemether-lumefantrine compared with quinine in pregnant women with uncomplicated Plasmodium falciparum malaria: an open-label, randomised, non-inferiority trial. [2010.11]
Comparison of quinine and rabeprazole with quinine monotherapy in the treatment of uncomplicated falciparum malaria. [2010.09]
A controlled trial to assess the effect of quinine, chloroquine, amodiaquine, and artesunate on Loa loa microfilaremia. [2010.03]
Artemisinin derivatives versus quinine for cerebral malaria in African children: a systematic review. [2009.12]
Effectiveness of quinine versus artemether-lumefantrine for treating uncomplicated falciparum malaria in Ugandan children: randomised trial. [2009.07.21]
Effects of concurrent administration of nevirapine on the disposition of quinine in healthy volunteers. [2009.04]
Intrarectal quinine versus intravenous or intramuscular quinine for treating Plasmodium falciparum malaria. [2009.01.21]
Artemisinin derivatives versus quinine in treating severe malaria in children: a systematic review. [2008.10.17]
Taste-masked quinine sulphate pellets: bio-availability in adults and steady-state plasma concentrations in children with uncomplicated Plasmodium falciparum malaria. [2008.06]
Rectal versus intravenous quinine for the treatment of childhood cerebral malaria in Kampala, Uganda: a randomized, double-blind clinical trial. [2007.12.01]
Artesunate versus quinine for treating severe malaria. [2007.10.17]
Azithromycin combination therapy with artesunate or quinine for the treatment of uncomplicated Plasmodium falciparum malaria in adults: a randomized, phase 2 clinical trial in Thailand. [2006.11.15]
Safety and efficacy of rectal compared with intramuscular quinine for the early treatment of moderately severe malaria in children: randomised clinical trial. [2006.05.06]
Clinical-parasitological response and in-vitro sensitivity of Plasmodium vivax to chloroquine and quinine on the western border of Thailand. [2006.05]
Effective treatment of uncomplicated Plasmodium falciparum malaria with azithromycin-quinine combinations: a randomized, dose-ranging study. [2006.03]
Successful treatment of Plasmodium falciparum malaria with a six-dose regimen of artemether-lumefantrine versus quinine-doxycycline in the Western Amazon region of Brazil. [2006.01]
A randomized comparison of artesunate-atovaquone-proguanil versus quinine in treatment for uncomplicated falciparum malaria during pregnancy. [2005.09.01]
Artesunate versus quinine for treatment of severe falciparum malaria: a randomised trial. [2005.08.27]
Artesunate-clindamycin versus quinine-clindamycin in the treatment of Plasmodium falciparum malaria: a randomized controlled trial. [2005.06.15]
Intrarectal quinine for treating Plasmodium falciparum malaria: a systematic review. [2005.05.18]
Managing nocturnal leg cramps--calf-stretching exercises and cessation of quinine treatment: a factorial randomised controlled trial. [2005.03]
N-of-1 trials of quinine efficacy in skeletal muscle cramps of the leg. [2005.03]
Rectal artemether versus intravenous quinine for the treatment of cerebral malaria in children in Uganda: randomised clinical trial. [2005.02.12]
Mefloquine versus quinine plus sulphalene-pyrimethamine (metakelfin) for treatment of uncomplicated imported falciparum malaria acquired in Africa. [2005.02]
A randomized open label clinical trial to compare the efficacy and safety of intravenous quinine followed by oral malarone vs. intravenous quinine followed by oral quinine in the treatment of severe malaria. [2005.02]
Intrarectal quinine for treating Plasmodium falciparum malaria. [2005.01.25]
Dose-dependent resorption of quinine after intrarectal administration to children with moderate Plasmodium falciparum malaria. [2004.11]
Efficacies of chloroquine, sulfadoxine-pyrimethamine and quinine in the treatment of uncomplicated, Plasmodium falciparum malaria in eastern Sudan. [2004.10]
Absolute bioavailability of quinine formulations in Nigeria. [2004.09]
Low-dose quinine for treatment of chloroquine-resistant falciparum malaria in Sudanese pregnant women. [2004.07]
Low-dose quinine is effective in the treatment of chloroquine-resistant Plasmodium falciparum malaria in eastern Sudan. [2004.07]
Efficacy of rectal artesunate compared with parenteral quinine in initial treatment of moderately severe malaria in African children and adults: a randomised study. [2004.05.15]
Randomized control trial of quinine and artesunate in complicated malaria. [2004.04]
A comparative clinical trial of artemether and quinine in children with severe malaria. [2003.10]
Metabolism and elimination of quinine in healthy volunteers. [2003.09]
Quinine as a multidrug resistance inhibitor: a phase 3 multicentric randomized study in adult de novo acute myelogenous leukemia. [2003.08.15]
Randomized comparison of artesunate and quinine in the treatment of severe falciparum malaria. [2003.07.01]
Quinine 3-hydroxylation as a biomarker reaction for the activity of CYP3A4 in man. [2003.05]
Adverse effect of rifampin on quinine efficacy in uncomplicated falciparum malaria. [2003.05]
Intrarectal pharmacokinetics of two formulations of quinine in children with falciparum malaria. [2003.02]
Comparison of intramuscular artemether and intravenous quinine in the treatment of Sudanese children with severe falciparum malaria. [2002.12]
Is quinine a suitable probe to assess the hepatic drug-metabolizing enzyme CYP3A4? [2002.12]
Interaction trial between artemether-lumefantrine (Riamet) and quinine in healthy subjects. [2002.10]
The efficacy of artemether versus quinine in the treatment of cerebral malaria. [2002.08]
[Treatment of cerebral malaria in African children by intravenous quinine: comparison of a loading dose regimen to a regimen without a loading dose] [2002.06]
Treatment of uncomplicated malaria in children in Guinea-Bissau with chloroquine, quinine, and sulfadoxine-pyrimethamine. [2002.05]
Effectiveness of quinine in treating muscle cramps: a double-blind, placebo-controlled, parallel-group, multicentre trial. [2002.05]
[Diluted injectable quinine in the intramuscular and intrarectal route: comparative efficacity and tolerance in malaria treatment for children ] [2002]
Randomized comparison of quinine-clindamycin versus artesunate in the treatment of falciparum malaria in pregnancy. [2001.11]
Randomized trial of artesunate and mefloquine in comparison with quinine sulfate to treat P. falciparum malaria pregnant women. [2001.09]
A comparison of artesunate alone with combined artesunate and quinine in the parenteral treatment of acute falciparum malaria. [2001.09]
[Intrarectal administration of quinine: an early treatment for severe malaria in children?] [2001.07]
Artemether vs quinine therapy in Plasmodium falciparum malaria in Manipur--a preliminary report. [2001.06]
Population pharmacokinetics of intramuscular quinine in children with severe malaria. [2001.06]
Clinical trial of beta-arteether versus quinine for the treatment of cerebral malaria in children in Yaounde, Cameroon. [2001.05]
Oral quinine pharmacokinetics and dietary salt intake. [2001.05]
A randomized controlled trial comparing artemether and quinine in the treatment of cerebral malaria in Bangladesh. [2001.03]
Controlled trial of 3-day quinine-clindamycin treatment versus 7-day quinine treatment for adult travelers with uncomplicated falciparum malaria imported from the tropics. [2001.03]
Randomized comparison of mefloquine-artesunate versus quinine in the treatment of multidrug-resistant falciparum malaria in pregnancy. [2000.11]
Therapeutic responses to quinine and clindamycin in multidrug-resistant falciparum malaria. [2000.09]
Rectal dihydroartemisinin versus intravenous quinine in the treatment of severe malaria: a randomised clinical trial. [2000.05]
Combinations of artemisinin and quinine for uncomplicated falciparum malaria: efficacy and pharmacodynamics. [2000.05]
The roles of cytochrome P450 3A4 and 1A2 in the 3-hydroxylation of quinine in vivo. [1999.11]
Comparative efficacy of intramuscular artemether and intravenous quinine in Nigerian children with cerebral malaria. [1999.10.15]
[Muscle cramps: reevaluation of the effectiveness of quinine salts] [1999.07.03]
Grapefruit juice has no effect on quinine pharmacokinetics. [1999.07]
The effects of quinine and artesunate treatment on plasma tumor necrosis factor levels in malaria-infected patients. [1999.03]
Comparison of rectal artemisinin with intravenous quinine in the treatment of severe malaria in Ethiopia. [1999.03]
Pharmacokinetic and pharmacodynamic interactions of mefloquine and quinine. [1999]
[Comparative study of artemether and quinine in severe Plasmodium falciparum malaria in adults and older children in Cameroon] [1999]
Quinine improves results of intensive chemotherapy (IC) in myelodysplastic syndromes (MDS) expressing P-glycoprotein (PGP). Updated results of a randomized study. Groupe Francais des Myelodysplasies (GFM) and Groupe GOELAMS. [1999]
Cost-effectiveness analysis of artesunate and quinine + tetracycline for the treatment of uncomplicated falciparum malaria in Chanthaburi, Thailand. [1999]
Halofantrine versus quinine-Fansidar combination in the treatment of post-chloroquine falciparum parasitaemia. [1998.09]
Quinine for nocturnal leg cramps: a meta-analysis including unpublished data. [1998.09]
Quinine improves the results of intensive chemotherapy in myelodysplastic syndromes expressing P glycoprotein: results of a randomized study. [1998.09]
Response of uncomplicated falciparum malaria to oral chloroquine and quinine in Burundi highlands. [1998.06.15]
Loading dose of quinine in African children with cerebral malaria. [1998.05]
Allopurinol as an additive to quinine in the treatment of acute complicated falciparum malaria. [1998.04]
Randomized comparison of intramuscular artemether and intravenous quinine in adult, Melanesian patients with severe or complicated, Plasmodium falciparum malaria in Papua New Guinea. [1998.03]
Intramuscular artemether vs intravenous quinine: an open, randomized trial in Malawian children with cerebral malaria. [1998.01]
Compliance with artesunate and quinine + tetracycline treatment of uncomplicated falciparum malaria in Thailand. [1998]
Differential response to intraoral sucrose, quinine and corn oil in crying human newborns. [1997.08]
Comparison of artemisinin suppositories, intramuscular artesunate and intravenous quinine for the treatment of severe childhood malaria. [1997.05]
Randomised controlled trial of hydroquinine in muscle cramps. [1997.02.22]
Combination of quinine as a potential reversing agent with mitoxantrone and cytarabine for the treatment of acute leukemias: a randomized multicenter study. [1996.08.15]
A controlled trial of artemether or quinine in Vietnamese adults with severe falciparum malaria. [1996.07.11]
A trial of artemether or quinine in children with cerebral malaria. [1996.07.11]
A comparative study of parenteral chloroquine, quinine and pyrimethamine-sulfadoxine in the treatment of Gambian children with complicated, non-cerebral malaria. [1996.06]
Therapeutic effects of chloroquine in combination with quinine in uncomplicated falciparum malaria. [1996.06]
An open randomized trial of artemether versus quinine in the treatment of cerebral malaria in African children. [1996.05]
Efficacy and pharmacokinetics of a new intrarectal quinine formulation in children with Plasmodium falciparum malaria. [1996.05]
Quinine-tetracycline for multidrug resistant falciparum malaria. [1996.03]
Reducing the oral quinine-quinidine-cinchonin (Quinimax) treatment of uncomplicated malaria to three days does not increase the recurrence of attacks among children living in a highly endemic area of Senegal. [1996.03]
Disposition of quinine in plasma after a single oral and intramuscular dose in healthy adult Africans. [1996.02]
Randomized controlled trial of artesunate plus tetracycline versus standard treatment (quinine plus tetracycline) for uncomplicated Plasmodium falciparum malaria in Brazil. [1996.02]
Effect of dose size on the pharmacokinetics of orally administered quinine. [1996]
Comparison of artemether and quinine in the treatment of severe falciparum malaria in south-east Thailand. [1995.11]
Marked enhancement by rifampicin and lack of effect of isoniazid on the elimination of quinine in man. [1995.07]
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