Media Articles Related to Qualaquin (Quinine)
Genes that protect African children from developing malaria identified
Source: Genetics News From Medical News Today [2015.10.01]
Published in Nature, the findings detail a new gene locus that can explain why, in communities where everyone is constantly exposed to malaria, some children develop severe malaria and others don't.
Humans and monkeys affected by the same malaria parasite in the Amazon region
Source: Infectious Diseases / Bacteria / Viruses News From Medical News Today [2015.09.29]
Research scientists in Tübingen discover indications that two types of parasites are actually one with several host species - this has consequences for the global battle against the...
Latest study looks at alternative therapies to prevent malaria in pregnancy
Source: Pregnancy / Obstetrics News From Medical News Today [2015.09.29]
Researchers at LSTM, working with colleagues of the Centres for Disease Control and Prevention (CDC) in Kenya and USA, and from the Kenya Medical Research Institution have found that a new drug may...
Malaria in pregnancy leads to cognitive defects in offspring
Source: Pregnancy / Obstetrics News From Medical News Today [2015.09.25]
New research on malaria in pregnancy, based on a study of fetus development in mice, shows a causal link between malaria in pregnancy and cognitive impairment.
Researchers find novel signature in the brains of children with cerebral malaria - disease exacerbated by HIV
Source: HIV / AIDS News From Medical News Today [2015.09.22]
Cells associated with inflammation and blood clotting accumulate in the brain blood vessels of children affected by a potentially fatal form of malaria called cerebral malaria (CM), potentially...
Published Studies Related to Qualaquin (Quinine)
Quinine-induced thrombocytopenia: drug-dependent GPIb/IX antibodies inhibit megakaryocyte and proplatelet production in vitro. [2011.06.02]
The development of immune cytopenias is a well-recognized side effect of many drugs...
Limited ability of Plasmodium falciparum pfcrt, pfmdr1, and pfnhe1 polymorphisms to predict quinine in vitro sensitivity or clinical effectiveness in Uganda. [2011.02]
Quinine is a standard drug for treating severe malaria in Africa, and it is also increasingly used to treat uncomplicated disease. However, failures of quinine therapy are common, and it is unknown if failures in Africa are due to drug resistance... Our data suggest that quinine sensitivity is a complex trait and that known polymorphisms in pfcrt, pfmdr1, and pfnhe1, while associated with quinine sensitivity, are not robust markers for quinine resistance.
Artesunate versus quinine in the treatment of severe falciparum malaria in African children (AQUAMAT): an open-label, randomised trial. [2010.11.13]
BACKGROUND: Severe malaria is a major cause of childhood death and often the main reason for paediatric hospital admission in sub-Saharan Africa. Quinine is still the established treatment of choice, although evidence from Asia suggests that artesunate is associated with a lower mortality. We compared parenteral treatment with either artesunate or quinine in African children with severe malaria... INTERPRETATION: Artesunate substantially reduces mortality in African children with severe malaria. These data, together with a meta-analysis of all trials comparing artesunate and quinine, strongly suggest that parenteral artesunate should replace quinine as the treatment of choice for severe falciparum malaria worldwide. FUNDING: The Wellcome Trust. Copyright (c) 2010 Elsevier Ltd. All rights reserved.
Efficacy and safety of artemether-lumefantrine compared with quinine in pregnant women with uncomplicated Plasmodium falciparum malaria: an open-label, randomised, non-inferiority trial. [2010.11]
BACKGROUND: Malaria in pregnancy is associated with maternal and fetal morbidity and mortality. In 2006, WHO recommended use of artemisinin-based combination treatments during the second or third trimesters, but data on efficacy and safety in Africa were scarce. We aimed to assess whether artemether-lumefantrine was at least as efficacious as oral quinine for the treatment of uncomplicated falciparum malaria during the second and third trimesters of pregnancy in Mbarara, Uganda... INTERPRETATION: Artemisinin derivatives are not inferior to oral quinine for the treatment of uncomplicated malaria in pregnancy and might be preferable on the basis of safety and efficacy. FUNDING: Medecins Sans Frontieres and the European Commission. Copyright (c) 2010 Elsevier Ltd. All rights reserved.
Comparison of quinine and rabeprazole with quinine monotherapy in the treatment of uncomplicated falciparum malaria. [2010.09]
OBJECTIVE: This study was conducted to assess the effect of combination treatment of quinine and rabeprazole in the treatment of uncomplicated Plasmodium falciparum malaria... CONCLUSION: The study results suggest that addition of rabeprazole to quinine regimen resulted in an increase in the parasite elimination rate, which may be helpful in reducing the duration of treatment and increasing patient compliance.
Clinical Trials Related to Qualaquin (Quinine)
Drug-Drug Interaction Study of Qualaquin and Midazolam [Completed]
This is an open label non-randomized single sequence, single group two way drug interaction
study in healthy adult volunteers to determine the extent to which quinine, an inducer of
cytochrome p450 CYP 3A4, affects the pharmacokinetics of midazolam, an accepted probe drug
for CYP 3A4. The study will also determine the extent to which midazolam affects the
pharmacokinetics of quinine.
Drug - Drug Interaction Study of Quinine Sulfate and Ciprofloxacin [Completed]
Ciprofloxacin is moderate inhibitor of cytochrome P450 1A2 (CYP1A2), one of the enzymes
responsible for the metabolism of quinine. This study will evaluate the effect of
ciprofloxacin-related inhibition of CYP1A2 on the pharmacokinetics of quinine sulfate.
Comparative Study of Quinine Sulfate in Healthy Patients and in Patients With Renal Impairment [Terminated]
The effects of mild or moderate renal impairment (creatinine clearance 30 to 50 ml/min or
>50 to 80 ml/min, respectively) on the pharmacokinetic profile of quinine and its active
metabolite, 3'-hydroxyquinine, will be investigated. Safety and tolerability in healthy
subjects versus those with mild to moderate renal impairment will be compared, as well.
Drug - Drug Interaction Study Between Quinine Sulfate and Theophylline [Completed]
In a prior in vitro study using human hepatocytes quinine was shown to induce the activity
of Cytochrome p450 CYP 1A2. The present study will evaluate the extent to which quinine
sulfate-related induction of this enzyme effects the pharmacokinetics of theophylline, a
sensitive probe drug for the activity of CYP 1A2. It will also evaluate the effect of
single-dose theophylline on the pharmacokinetics of steady-state quinine sulfate.
Drug-Drug Interaction Study Between Quinine Sulfate and Rosiglitazone [Completed]
Rosiglitazone is predominantly metabolized by cytochrome P450 (CYP) 2C8. Quinine sulfate is
an inhibitor of CYP 2C8. This study will evaluate the effect of multiple doses of quinine
sulfate at steady-state on the pharmacokinetics of single-dose rosiglitazone in healthy
Reports of Suspected Qualaquin (Quinine) Side Effects
OFF Label USE (7),
Hearing Impaired (2),
Pruritus Generalised (1),
Oedema Peripheral (1),
Nervousness (1), more >>