Pyrazinamide (Pyrazinamide) - Drug Interactions, Contraindications, Overdosage

DRUG INTERACTIONS

Drug/Laboratory Test Interactions:

Pyrazinamide has been reported to interfere with ACETEST^® and KETOSTIX^® urine tests to produce a pink-brown color.⁵

OVERDOSAGE:

Overdosage experience is limited. In one case report of overdose, abnormal liver function tests developed. These spontaneously reverted to normal when the drug was stopped. Clinical monitoring and supportive therapy should be employed. Pyrazinamide is dialyzable.¹³

CONTRAINDICATIONS:

Pyrazinamide is contraindicated in persons:

• with severe hepatic damage.
• who have shown hypersensitivity to it.
• with acute gout.