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Purinethol (Mercaptopurine) - Published Studies

 
 



Purinethol Related Published Studies

Well-designed clinical trials related to Purinethol (Mercaptopurine)

Randomized trial to compare LSA2L2-type maintenance therapy to daily 6-mercaptopurine and weekly methotrexate with vincristine and dexamethasone pulse for children with acute lymphoblastic leukemia. [2010.08]

Azathioprine or 6-mercaptopurine for induction of remission in Crohn's disease. [2010.06.16]

Benefits of the intermittent use of 6-mercaptopurine and methotrexate in maintenance treatment for low-risk acute lymphoblastic leukemia in children: randomized trial from the Brazilian Childhood Cooperative Group--protocol ALL-99. [2010.04.10]

Oral 6-mercaptopurine versus oral 6-thioguanine and veno-occlusive disease in children with standard-risk acute lymphoblastic leukemia: report of the Children's Oncology Group CCG-1952 clinical trial. [2010.04.08]

Azathioprine or 6-mercaptopurine for induction of remission in Crohn's disease. [2010]

Azathioprine or 6-mercaptopurine for induction of remission in Crohn's disease. [2009.10.07]

Toxicity and efficacy of 6-thioguanine versus 6-mercaptopurine in childhood lymphoblastic leukaemia: a randomised trial. [2006.10.14]

Intravenous 6-mercaptopurine decreases salvage after relapse in childhood acute lymphoblastic leukemia: a report from the Children's Cancer Group study CCG 1922. [2005.07]

Value of intravenous 6-mercaptopurine during continuation treatment in childhood acute lymphoblastic leukemia and non-Hodgkin's lymphoma: final results of a randomized phase III trial (58881) of the EORTC CLG. [2005.05]

Postoperative maintenance of Crohn's disease remission with 6-mercaptopurine, mesalamine, or placebo: a 2-year trial. [2004.09]

A comparison of red blood cell thiopurine metabolites in children with acute lymphoblastic leukemia who received oral mercaptopurine twice daily or once daily: a Pediatric Oncology Group study (now The Children's Oncology Group). [2004.08]

High-performance liquid chromatographic assay of metabolites of thioguanine and mercaptopurine in capillary blood. [2003.10.25]

Thioguanine offers no advantage over mercaptopurine in maintenance treatment of childhood ALL: results of the randomized trial COALL-92. [2003.10.15]

Antagonism by methotrexate on mercaptopurine disposition in lymphoblasts during up-front treatment of acute lymphoblastic leukemia. [2003.06]

Dexamethasone versus prednisone and daily oral versus weekly intravenous mercaptopurine for patients with standard-risk acute lymphoblastic leukemia: a report from the Children's Cancer Group. [2003.05.15]

Intensification of mercaptopurine/methotrexate maintenance chemotherapy may increase the risk of relapse for some children with acute lymphoblastic leukemia. [2003.04.01]

De novo purine synthesis inhibition and antileukemic effects of mercaptopurine alone or in combination with methotrexate in vivo. [2002.08.15]

A comparison of early intensive methotrexate/mercaptopurine with early intensive alternating combination chemotherapy for high-risk B-precursor acute lymphoblastic leukemia: a Pediatric Oncology Group phase III randomized trial. [2001.07]

6-mercaptopurine or methotrexate added to prednisone induces and maintains remission in steroid-dependent inflammatory bowel disease. [2000.11]

A multicenter trial of 6-mercaptopurine and prednisone in children with newly diagnosed Crohn's disease. [2000.10]

Pharmacotherapy for inducing and maintaining remission in pouchitis. [2000]

Mercaptopurine therapy intolerance and heterozygosity at the thiopurine S-methyltransferase gene locus. [1999.12.01]

No beneficial effect from addition of etoposide to daunorubicin, cytarabine, and 6-mercaptopurine in individualized induction therapy of adult acute myeloid leukemia: the JALSG-AML92 study. Japan Adult Leukemia Study Group. [1999.08]

Methotrexate compared with mercaptopurine for early induced abortion. [1999.06]

Intermediate-dose intravenous methotrexate with intravenous mercaptopurine is superior to repetitive low-dose oral methotrexate with intravenous mercaptopurine for children with lower-risk B-lineage acute lymphoblastic leukemia: a Pediatric Oncology Group phase III trial. [1998.01]

Pharmacokinetics and metabolism of thiopurines in children with acute lymphoblastic leukemia receiving 6-thioguanine versus 6-mercaptopurine. [1998]

Pharmacokinetics and distribution of 6-mercaptopurine administered intravenously in children with lymphoblastic leukaemia. [1997]

A phase III randomized prospective trial of external beam radiotherapy, mitomycin C, carmustine, and 6-mercaptopurine for the treatment of adults with anaplastic glioma of the brain. CNS Cancer Consortium. [1996.03.01]

Azathioprine and 6-mercaptopurine in Crohn disease. A meta-analysis. [1995.07.15]

Nationwide randomized comparative study of daunorubicin and aclarubicin in combination with behenoyl cytosine arabinoside, 6-mercaptopurine, and prednisolone for previously untreated acute myeloid leukemia. [1994]

Oral mercaptopurine in childhood leukemia: influence of food intake on bioavailability. [1989]

Comparison of intermittent or continuous methotrexate plus 6-mercaptopurine in regimens for standard-risk acute lymphoblastic leukemia in childhood (JCCLSG-S811). The Japanese Children's Cancer and Leukemia Study Group. [1988.04.01]

Well-designed clinical trials possibly related to Purinethol (Mercaptopurine)

Interferon, azathioprine and corticosteroids in multiple sclerosis: 6-year follow-up of the ASA cohort. [2012]

Individually tailored treatment of medication nonadherence. [2011.10]

Impact of de novo everolimus-based immunosuppression on incisional complications in heart transplantation. [2011.09.15]

A randomized trial of methotrexate versus azathioprine for severe atopic eczema. [2011.08]

Effect of everolimus introduction on cardiac allograft vasculopathy--results of a randomized, multicenter trial. [2011.07.27]

Escalating intravenous methotrexate improves event-free survival in children with standard-risk acute lymphoblastic leukemia: a report from the Children's Oncology Group. [2011.07.14]

Assessment of thiopurine S-methyltransferase activity in patients prescribed thiopurines: a systematic review. [2011.06.21]

Long-term results of a randomized controlled trial in childhood IgA nephropathy. [2011.06]

Impact of maintenance immunosuppressive regimens--balance between graft protective suppression of immune functions and a near physiological immune response. [2011.06]

Steroids and azathioprine in the treatment of IgA nephropathy. [2011.06]

AIDA 0493 protocol for newly diagnosed acute promyelocytic leukemia: very long-term results and role of maintenance. [2011.05.05]

The influence of immunosuppression switching in liver function in adult hepatic transplantation. [2011.03]

[Bullous pemphigoid: a review]. [2011.03]

Cyclosporine versus azathioprine therapy in high-risk idiopathic membranous nephropathy patients: A 3-year prospective study. [2011.03]

Comparison of sirolimus with azathioprine in a tacrolimus-based immunosuppressive regimen in lung transplantation. [2011.02.01]

Increased risk of venous thromboembolism with a sirolimus-based immunosuppression regimen in lung transplantation. [2011.02]

The 6-MP versus placebo clinical trial in acute leukemia. [2011]

Effect of mitoxantrone on outcome of children with first relapse of acute lymphoblastic leukaemia (ALL R3): an open-label randomised trial. [2010.12.11]

Mycophenolate mofetil vs azathioprine for remission maintenance in antineutrophil cytoplasmic antibody-associated vasculitis: a randomized controlled trial. [2010.12.01]

Infliximab, azathioprine or combination therapy in the treatment of active Crohn's disease. [2010.12]

Azathioprine versus mycophenolate mofetil for long-term immunosuppression in lupus nephritis: results from the MAINTAIN Nephritis Trial. [2010.12]

Cytomegalovirus risk factors in renal transplantation with modern immunosuppression. [2010.12]

Arsenic trioxide improves event-free and overall survival for adults with acute promyelocytic leukemia: North American Leukemia Intergroup Study C9710. [2010.11.11]

Addition of azathioprine to corticosteroids does not benefit patients with IgA nephropathy. [2010.10]

Treatment of relapsing mild-to-moderate ulcerative colitis with the probiotic VSL#3 as adjunctive to a standard pharmaceutical treatment: a double-blind, randomized, placebo-controlled study. [2010.10]

Rituximab in intractable ocular lesions of Behcet's disease; randomized single-blind control study (pilot study). [2010.08]

Immunosuppressive effects via human intestinal dendritic cells of probiotic bacteria and steroids in the treatment of acute ulcerative colitis. [2010.08]

Thiopurine maintenance therapy for ulcerative colitis: the clinical significance of monitoring 6-thioguanine nucleotide. [2010.08]

Azathioprine versus mesalazine for prevention of postoperative clinical recurrence in patients with Crohn's disease with endoscopic recurrence: efficacy and safety results of a randomised, double-blind, double-dummy, multicentre trial. [2010.06]

Comparison of the clinical efficacy of two different immunosuppressive regimens in patients with chronic vogt-koyanagi-harada disease. [2010.06]

Infliximab, azathioprine, or combination therapy for Crohn's disease. [2010.04.15]

Treatment of polyarteritis nodosa and microscopic polyangiitis without poor-prognosis factors: A prospective randomized study of one hundred twenty-four patients. [2010.04]

Determination of 6-thioguanosine diphosphate and triphosphate and nucleoside diphosphate kinase activity in erythrocytes: novel targets for thiopurine therapy? [2010.04]

The BILAG multi-centre open randomized controlled trial comparing ciclosporin vs azathioprine in patients with severe SLE. [2010.04]

Very long-term outcome of acute promyelocytic leukemia after treatment with all-trans retinoic acid and chemotherapy: the European APL Group experience. [2010.03.04]

The 10-year follow-up data of the Euro-Lupus Nephritis Trial comparing low-dose and high-dose intravenous cyclophosphamide. [2010.01]

Outcome of recurrent hepatitis C virus after liver transplantation in a randomized trial of tacrolimus monotherapy versus triple therapy. [2009.12]

Lung function in idiopathic pulmonary fibrosis--extended analyses of the IFIGENIA trial. [2009.10.27]

A pilot study comparing hydrocortisone premedication to concomitant azathioprine treatment in preventing loss of response to infliximab. [2009.09]

Randomized study of interferon beta-1a, low-dose azathioprine, and low-dose corticosteroids in multiple sclerosis. [2009.08]

Randomized study on the efficacy of immunosuppressive therapy in patients with virus-negative inflammatory cardiomyopathy: the TIMIC study. [2009.08]

Gray matter atrophy and disability progression in patients with early relapsing-remitting multiple sclerosis: a 5-year longitudinal study. [2009.07.15]

Intravenous immunoglobulin as adjuvant therapy for Wegener's granulomatosis. [2009.07.08]

Cyclosporine withdrawal improves long-term graft survival in renal transplantation. [2009.06.27]

Treating childhood acute lymphoblastic leukemia without cranial irradiation. [2009.06.25]

Recurrence of Crohn's disease after ileocolic resection is not affected by anastomotic type: results of a multicenter, randomized, controlled trial. [2009.05]

Safe conversion of mycophenolate mofetil to azathioprine in kidney transplant recipients with sirolimus-based immunosuppression. [2009.04]

Azathioprine is superior to budesonide in achieving and maintaining mucosal healing and histologic remission in steroid-dependent Crohn's disease. [2009.03]

Thiopurine methyltransferase activity is related to the risk of relapse of childhood acute lymphoblastic leukemia: results from the NOPHO ALL-92 study. [2009.03]

Efficacy of infliximab in pediatric Crohn's disease: a randomized multicenter open-label trial comparing scheduled to on demand maintenance therapy. [2009.03]

Review article: Progress of treatment in ANCA-associated vasculitis. [2009.02]

Azathioprine withdrawal in patients with Crohn's disease maintained on prolonged remission: a high risk of relapse. [2009.01]

Multicentre prospective randomised trial of tacrolimus, azathioprine and prednisolone with or without basiliximab: two-year follow-up data. [2009.01]

20-year follow-up results of a randomized controlled trial comparing antilymphocyte globulin induction to no induction in renal transplant patients. [2008.12.27]

Azathioprine or methotrexate maintenance for ANCA-associated vasculitis. [2008.12.25]

Usefulness of immunosuppression for giant cell myocarditis. [2008.12.01]

A randomized prospective trial of endoscopic ultrasound to guide combination medical and surgical treatment for Crohn's perianal fistulas. [2008.10]

Therapy of metronidazole with azathioprine to prevent postoperative recurrence of Crohn's disease: a controlled randomized trial. [2008.10]

Basiliximab induction therapy for live donor kidney transplantation: a long-term follow-up of prospective randomized controlled study. [2008.10]

A multicenter, randomized, double-blind trial of everolimus versus azathioprine and placebo to maintain steroid-induced remission in patients with moderate-to-severe active Crohn's disease. [2008.09]

Azathioprine versus betamethasone for the treatment of parthenium dermatitis: a randomized controlled study. [2008.09]

Withdrawal of immunosuppression in Crohn's disease treated with scheduled infliximab maintenance: a randomized trial. [2008.06]

Supportive Versus Immunosuppressive Therapy of Progressive IgA Nephropathy (STOP) IgAN trial: rationale and study protocol. [2008.05]

Evolution of different MRI measures in patients with active relapsing-remitting multiple sclerosis over 2 and 5 years: a case-control study. [2008.04]

Improved outcome in multisystem Langerhans cell histiocytosis is associated with therapy intensification. [2008.03.01]

Rescue immunosuppressive therapies in living-related renal allotransplant: a long-term prospective randomized evaluation. [2008.03]

Early combined immunosuppression or conventional management in patients with newly diagnosed Crohn's disease: an open randomised trial. [2008.02.23]

Treatment of Churg-Strauss syndrome without poor-prognosis factors: a multicenter, prospective, randomized, open-label study of seventy-two patients. [2008.02]

Long-term results of the AIEOP-ALL-95 Trial for Childhood Acute Lymphoblastic Leukemia: insight on the prognostic value of DNA index in the framework of Berlin-Frankfurt-Muenster based chemotherapy. [2008.01.10]

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