DOSAGE AND ADMINISTRATION
The recommended dose for use in most cystic fibrosis patients is one 2.5 mg single-use ampule inhaled once daily using a recommended nebulizer. Some patients may benefit from twice daily administration (see Clinical Experience, Table 1). Clinical trial results and laboratory information are only available to support use of the following nebulizer/compressor systems (see Table 3).
Table 3: Recommended Nebulizer/Compressor Systems
Jet Nebulizer |
|
Compressor |
Hudson T Up-draft II® with |
|
Pulmo-Aide®
|
Marquest Acorn II® with |
|
Pulmo-Aide®
|
PARI LC Jet+ with |
|
PARI PRONEB®
|
PARI BABY™ with |
|
PARI PRONEB®
|
Durable Sidestream® with |
|
MOBILAIRE™
|
Durable Sidestream® with |
|
Porta-Neb®
|
Patients who use the Sidestream® Nebulizer with the MOBILAIRE™ compressor should turn the compressor control knob fully to the right and then turn on the compressor. At this setting, the needle on the pressure gauge should vibrate between 35 and 45 pounds per square inch (highest pressure output).
No data are currently available that support the administration of Pulmozyme with other nebulizer systems. The patient should follow the manufacturer's instructions on the use and maintenance of the equipment.
Pulmozyme should not be diluted or mixed with other drugs in the nebulizer. Mixing of Pulmozyme with other drugs could lead to adverse physicochemical and/or functional changes in Pulmozyme or the admixed compound. Patients should be advised to squeeze each ampule prior to use in order to check for leaks.
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