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Psoriatec (Anthralin) - Summary

 
 



PSORIATEC SUMMARY

Psoriatec (anthralin cream 1.0%, USP) is a smooth, yellow cream containing 1% anthralin USP in an aqueous cream base of glyceryl monolaurate, glyceryl monomyristate, citric acid, sodium hydroxide and purified water. For topical dermatological use only.

For the topical treatment of psoriasis.


See all Psoriatec indications & dosage >>

NEWS HIGHLIGHTS

Media Articles Related to Psoriatec (Anthralin)

Several Treatment Options May Improve Nail Psoriasis
Source: Medscape Dermatology Headlines [2014.12.10]
Treatment of nail psoriasis poses a clinical challenge and may ultimately require more than one approach, according to new best practice recommendations.
Reuters Health Information

Picture of Psoriasis 1
Source: MedicineNet Psoriasis Specialty [2014.12.09]
Title: Picture of Psoriasis 1
Category: Images
Created: 11/11/2009 4:29:00 PM
Last Editorial Review: 12/9/2014 12:00:00 AM

Positive results from third and final pivotal Phase 3 study of brodalumab in patients with moderate-to-severe plaque psoriasis announced
Source: Dermatology News From Medical News Today [2014.11.28]
Amgen and AstraZeneca have announced that AMAGINE-2(TM), a pivotal, multi-arm Phase 3 trial evaluating two doses of brodalumab in more than 1,800 patients with moderate-to-severe plaque psoriasis...

Positive results from second pivotal Phase 3 study of Brodalumab in patients with moderate-to-severe plaque psoriasis announced
Source: Dermatology News From Medical News Today [2014.11.13]
Amgen and AstraZeneca has announced that AMAGINE-3(TM), a pivotal, multi-arm Phase 3 trial evaluating two doses of brodalumab in more than 1,800 patients with moderate-to-severe plaque psoriasis...

Brodalumab Beats Stelara in Psoriasis Trial, Sponsors Say
Source: MedPage Today Dermatology [2014.11.11]
(MedPage Today) -- More patients achieve total plaque clearance in topline results.

more news >>

Published Studies Related to Psoriatec (Anthralin)

Comparison of azelaic acid and anthralin for the therapy of patchy alopecia areata: a pilot study. [2005]
CONCLUSION: The present pilot study showed that the use of azelaic acid gave similar results to anthralin with regard to hair regrowth, and that it can be an effective topical therapy for patchy AA. More extensive trials are necessary, however, to reach a definitive conclusion.

Effect of H1-receptor blockade on anthralin inflammation. [1992]
The effect of terfenadine, an H1-receptor antagonist, on anthralin inflammation was studied in 12 subjects. Subjects were randomised to receive terfenadine 60 mg or placebo b.d... This study shows that H1-receptor blockade does not inhibit anthralin inflammation.

Anthralin-corticosteroid combination therapy in the treatment of chronic plaque psoriasis. [1988.04]
A prospective randomized trial of anthralin in Lassar's paste compared with anthralin in 0.0125% clobetasol propionate in the treatment of chronic plaque psoriasis was undertaken. The psoriatic skin of patients treated with the corticosteroid-anthralin combination cleared significantly more quickly than those treated with anthralin alone, with a mean time to clearance of 14.9 days compared with 18.5 days, and with lower concentrations of anthralin...

An EPR method for estimating activity of antioxidants in mouse skin using an anthralin-derived radical model. [2010.03]
Inhibitory effects of intravenously or orally administered antioxidants on the anthralin-derived radical generated in skin (mainly in the epidermis) of living mice by ultraviolet-A (UVA) irradiation were estimated. Anthralin was applied to the dorsal skin of living mice and the mice were then exposed to UVA.

Fluorescence remission spectroscopy of psoriatic lesions and the effect of topical anthralin therapy. [2009.12]
BACKGROUND: Psoriatic lesions are characterized by induration, scaling and erythema. Erythema is a result of inflammation and increased microvascular blood flow. Anthralin is the strongest topical antipsoriatic drug that causes clearing of psoriatic lesions and temporary remission. OBJECTIVE: The objective evaluation of skin perfusion might be a suitable way to gain a better insight in the pathophysiological process of this disease and to evaluate the response to antipsoriatic anthralin therapy... CONCLUSIONS: Vascular perfusion is increased in psoriatic lesions as demonstrated by remission spectroscopy. NADH-fluorescence is reduced in lesional psoriatic skin and in anthralin-induced erythema. FRIS is a suitable tool for objective evaluation of the cutaneous response to antipsoriatic treatment.

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Clinical Trials Related to Psoriatec (Anthralin)

Steroids Added to Dithranol and Narrow Band UVB(Ultraviolet B) (UVBnb) in Psoriasis [Recruiting]
Objective(s): (i) To assess the effect of adjunctive topical steroids in the combined treatment with UVBnb and dithranol on the remission time after therapy till a relapse of psoriasis defined as 50% loss of PASI (Psoriasis Area and Severity Index) improvement obtained through the antecedent treatment. (ii) To assess the impact of adjuvant topical steroids in the combined treatment with UVBnb and dithranol on the clearing time of psoriasis lesions under therapy (PASI 75).

- Trial with medicinal product

A Study of Topical Indigo Naturalis Treatment in Patients With Mild to Moderate Plaque-type Psoriasis [Recruiting]
Psoriasis is a distressing, chronic dermatitis. Plague-type psoriasis is the most common form of the disease, occurring in more than 80% of the cases. This type of psoriasis is characterised by sharply dermatcated, erythematous, scaling plagues that typically affect the elbows, knees, scalp, and intergluteal cleft. Estimates of the prevalence of psoriasis is vary from 0. 5% to 4. 6%, with rate varying between countries and races. The prevalence of psoriasis was about 2% in Taiwan. The cause of psoriasis remains unknown; however, it has been linked to complex interactions between predisposing genes and the environment. Current treatment of psoriasis included topical therapy (eg. topical corticosteroids, tars, anthralin, vitamin D analogues, Retinodes), phototherapy and systemic therapy (eg. Methotrexate, cyclosporine, Retinoids, Biologics). Although beneficial, all have undesirable adverse effects.

Effect of Adalimumab on Vascular Inflammation in Patients With Moderate to Severe Plaque Psoriasis [Recruiting]
This study is to determine the effect of adalimumab on inflammation of blood vessels that could lead to heart attack in patients with psoriasis. Changes to the carotid artery and ascending aorta will be evaluated in patients treated with adalimumab (systemic treatment) and compared against patients treated with a topical treatment that does not affect the entire body.

Evaluation of Vitamin D Levels in Psoriasis Patients [Recruiting]
The purpose of this research study is to find out more about the relationship between vitamin D and psoriasis.

more trials >>


Page last updated: 2014-12-10

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