PROZAC SUMMARY
Prozac® (fluoxetine hydrochloride) is a psychotropic drug for oral administration. It is also marketed for the treatment of premenstrual dysphoric disorder (Sarafem®, fluoxetine hydrochloride).
Prozac is indicated for the following:
MAJOR DEPRESSIVE DISORDER
Prozac is indicated for the treatment of major depressive disorder.
OBSESSIVE-COMPULSIVE DISORDER
Prozac is indicated for the treatment of obsessions and compulsions in patients with obsessive-compulsive disorder (OCD), as defined in the DSM-III-R; i.e., the obsessions or compulsions cause marked distress, are time-consuming, or significantly interfere with social or occupational functioning.
BULIMIA NERVOSA
Prozac is indicated for the treatment of binge-eating and vomiting behaviors in patients with moderate to severe bulimia nervosa.
PANIC DISORDER
Prozac is indicated for the treatment of panic disorder, with or without agoraphobia, as defined in DSM-IV. Panic disorder is characterized by the occurrence of unexpected panic attacks, and associated concern about having additional attacks, worry about the implications or consequences of the attacks, and/or a significant change in behavior related to the attacks.
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NEWS HIGHLIGHTSMedia Articles Related to Prozac (Fluoxetine)
TAU Seeks Genetic "Prozac Markers" To Find A Simple Test For Treating Depression
Source: Depression News From Medical News Today [2009.10.28]
Prozac works wonders for some depressed people, but not for others. In some cases, patients derive little benefit and at worst, it can lead to bizarre hallucinations and fits of rage. Researchers and doctors remain puzzled as to what causes the wide range of reaction to Prozac and similar antidepressants. The answer, Tel Aviv University researchers believe, can be found in a patient's genes.
Prozac improves learning and memory in Huntington's disease
Source: The Doctors Lounge - Neurology
Scientists in Melbourne found that fluoxetine improves depression, learning and memory in Huntington's disease.
Published Studies Related to Prozac (Fluoxetine)
Randomized, controlled clinical trial of the efficacy of fluoxetine for treatment of compulsive disorders in dogs. [2009.09.15]
OBJECTIVE: To evaluate efficacy of fluoxetine hydrochloride for treatment of compulsive disorders in dogs... The present study did not examine whether fluoxetine was more efficacious than or synergistic with behavioral and environment modifications.
A randomized double-blind clinical trial on analgesic efficacy of fluoxetine for persistent somatoform pain disorder. [2009.09.04]
OBJECTIVES: To verify the efficacy and safety of fluoxetine in treating patients with persistent somatoform pain disorder (PSPD)... CONCLUSIONS: Fluoxetine has a better analgesic effect than a placebo in treating persistent somatoform pain disorder, and is considered a safe treatment; its analgesic effect may be related to an antidepressant effect.
Homeopathic Individualized Q-potencies versus Fluoxetine for Moderate to Severe Depression: Double-blind, Randomized Non-inferiority Trial. [2009.08.17]
Homeopathy is a complementary and integrative medicine used in depression, The aim of this study is to investigate the non-inferiority and tolerability of individualized homeopathic medicines [Quinquagintamillesmial (Q-potencies)] in acute depression, using fluoxetine as active control... This study illustrates the feasibility of randomized controlled double-blind trials of homeopathy in depression and indicates the non-inferiority of individualized homeopathic Q-potencies as compared to fluoxetine in acute treatment of outpatients with moderate to severe depression.
Combination of acupuncture and fluoxetine for depression: a randomized, double-blind, sham-controlled trial. [2009.08]
BACKGROUND AND OBJECTIVE: The current pharmacological management of depression remains limited. The aim of this study was to assess the efficacy and safety of acupuncture in combination with fluoxetine as an intervention for major depressive disorder (MDD). SUBJECTS AND INTERVENTIONS: A total of 80 patients with MDD (DSM-IV) were randomized to two groups: VA group received verum acupuncture, 10 mg/day fluoxetine and placebo; SA group received sham acupuncture and 20-30 mg/day fluoxetine. Acupuncture was applied 5 times a week over a period of 6 weeks... CONCLUSIONS: Additionally applied standardized acupuncture to low-dose fluoxetine for depression is as effective as a recommended dose of fluoxetine treatment. Depressive patients with severe anxious symptoms and/or intolerable side-effects of antidepressants can benefit from it.
Effectiveness and safety of the combination of fluoxetine and olanzapine in outpatients with bipolar depression: an open-label, randomized, flexible-dose study in Puerto Rico. [2009.08]
We studied the effectiveness of olanzapine/fluoxetine combination (OFC) treatment of bipolar depressive episode (7 weeks, study period 1 [SP1]). Study period 1 responders (mean modal daily OFC dosage, 10.8/27.8 mg) were randomized to OFC continuation treatment or olanzapine (OLZ) monotherapy starting at 10 mg (12 weeks, SP2)...
Clinical Trials Related to Prozac (Fluoxetine)
Fasting Study of Fluoxetine Capsules 40 mg and Prozac Pulvules 40 mg [Completed]
The objective of this study is to investigate the bioequivalence of Mylan's fluoxetine
hydrochloride 40 mg capsules to Dista's Prozac 40 mg pulvules following a single, oral 40 mg
(1 x 40 mg) dose administration under fasting conditions.
Open Label Trial of Fluoxetine for the Treatment of Depression in Patients With End Stage Renal Disease [Active, not recruiting]
The purpose of this study is to test whether once-weekly prozac therapy leads to reduction in
depression in patients requiring kidney dialysis.
The Study of Olanzapine Plus Fluoxetine in Combination for Treatment of Treatment Resistant Depression [Completed]
The purposes of this study are to determine:
- Whether olanzapine plus fluoxetine in combination will help patients with
treatment-resistant major depression.
- The safety of olanzapine plus fluoxetine in combination, plus and any side effects that
might be associated with the combination.
- The effectiveness of olanzapine plus fluoxetine compared to olanzapine and fluoxetine
alone.
Effectiveness of Early Intervention With Fluoxetine in Enhancing Developmental Processes in Children With Autism (STAART Study 2) [Completed]
Danish Carvedilol Study in Portal Hypertension [Recruiting]
Patients with large esophageal varices who have not yet experienced bleeding, are normally
treated with propranolol, a beta blocking agent that reduces the portal pressure and thereby
diminish the risk of bleeding. 20-40% of the patients do not respond to this treatment or
have to discontinue the treatment because of side effects. The aim of this study is to
evaluate if carvedilol (a combined alfa - beta blocker) has better efficacy and safety than
propranolol in lowering the portal pressure in patients with cirrhosis.
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PATIENT REVIEWS / RATINGS / COMMENTSBased on a total of 49 ratings/reviews, Prozac has an overall score of 7.22. The effectiveness score is 7.88 and the side effect score is 7.18. The scores are on ten point scale: 10 - best, 1 - worst. Below are selected reviews: the highest, the median and the lowest rated.
| | Prozac review by 35 year old female patient | | | Rating |
| Overall rating: | |  |
| Effectiveness: | | Highly Effective |
| Side effects: | | No Side Effects | | |
Treatment Info |
| Condition / reason: | | Depression |
| Dosage & duration: | | 20mg. taken once a day for the period of past 3 years |
| Other conditions: | | High cholesterol |
| Other drugs taken: | | Lovastatin | | |
Reported Results |
| Benefits: | | Within a few days, my mood, self-esteem, attitude and over-all well-being improved tremendously! I went from feeling suicidal and not being able to funtion properly in order to take care of myself or my family, to feeling better than I had since I was in my teens. I began to lose some of the weight I had gained from being depressed. I was in a wonderful mood and I had so much more energy than I had in years. My overall experience with Prozac has been perfect! |
| Side effects: | | I have had no known side effects to this date. I do watch out for muscle cramps that last more than a week and I have blood work done once a year to ensure that my kidneys are not being affected. |
| Comments: | | I started on 10 mgs. once a day and when that was tolerated well I went up to 40 mgs. This caused some insomnia and nervousness so my Dr. lowered it to 20 mgs. a day. There are still times I get depressed for a few days but that only happens once or twice a year and it is mild. I am looking at being on Prozac as long as my body toleates it, due to once being taken off I went into a fast downward spiral and had to begin again. |
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| | Prozac review by 17 year old female patient | | | Rating |
| Overall rating: | |  |
| Effectiveness: | | Moderately Effective |
| Side effects: | | Mild Side Effects | | |
Treatment Info |
| Condition / reason: | | depression |
| Dosage & duration: | | 80mg taken trice a day for the period of 3 years |
| Other conditions: | | anorexia |
| Other drugs taken: | | zyprexa, motilium, pharmaton, letter, etc. | | |
Reported Results |
| Benefits: | | I felt better mood, optimism towards life in general, greater control of portion sizes. My recovery from anorexia was not easy, so I had a few months of moderate bulimia. It was then that my dosage grew bigger: 3 pills of 20 mg per day, though some days I would have 4 pills. |
| Side effects: | | don't recall |
| Comments: | | it takes very long, and requires a very large amount of patience. |
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| | Prozac review by 31 year old female patient | | | Rating |
| Overall rating: | | |
| Effectiveness: | | Ineffective |
| Side effects: | | Extremely Severe Side Effects | | |
Treatment Info |
| Condition / reason: | | Severe Anxiety |
| Dosage & duration: | | 20 mg per day taken once per day for the period of one week |
| Other conditions: | | none |
| Other drugs taken: | | Diazepam | | |
Reported Results |
| Benefits: | | This medication did not make me sedated or cause constipation like the last one I tried and I had no trouble getting to sleep at night. |
| Side effects: | | On the first day of taking this medication, I became extremely high and anxious within an hour of taking it. I then went on a major shopping spree, had major increased energy and talked a lot more then I usually do. By the second night, I started crying and could not stop and my teeth would not stop chattering. Over the next few days I became like a zombie during the day, but by night I would be a crying shaking mess. On the last day of taking this medication I was truly suicidal and I was not even depressed when I started this medication a week earlier. This medication was to treat severe anxiety only, and it did help for this, but made me severely depressed as a consequence. This medication may be very beneficial for some people, but it did not work for me. |
| Comments: | | I started taking one 10mg tablet of Fluoxetine in the morning for three days and then changed to one 20mg tablet in the morning |
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Page last updated: 2009-10-28
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