PROTOPAM SUMMARY
PROTOPAM Chloride (pralidoxime chloride) for Injection
Rx only
Pralidoxime chloride is a cholinesterase reactivator.
PROTOPAM is indicated as an antidote: (1) in the treatment of poisoning due to those pesticides and chemicals of the organophosphate class which have anticholinesterase activity and (2) in the control of overdosage by anticholinesterase drugs used in the treatment of myasthenia gravis.
The principal indications for the use of pralidoxime are muscle weakness and respiratory depression. In severe poisoning, respiratory depression may be due to muscle weakness.
|
NEWS HIGHLIGHTS
Published Studies Related to Protopam (Pralidoxime)
Pralidoxime in acute organophosphorus insecticide poisoning--a randomised controlled trial. [2009.06.30]
CONCLUSIONS: Despite clear reactivation of red cell acetylcholinesterase in diethyl organophosphorus pesticide poisoned patients, we found no evidence that this regimen improves survival or reduces need for intubation in patients with organophosphorus insecticide poisoning. The reason for this failure to benefit patients was not apparent. Further studies of different dose regimens or different oximes are required.
Continuous pralidoxime infusion versus repeated bolus injection to treat organophosphorus pesticide poisoning: a randomised controlled trial. [2006.12.16]
BACKGROUND: The role of oximes for the treatment of organophosphorus pesticide poisoning has not been conclusively established. We aimed to assess the effectiveness of a constant pralidoxime infusion compared with repeated bolus doses to treat patients with moderately severe poisoning from organophosphorus pesticides... INTERPRETATION: A high-dose regimen of pralidoxime, consisting of a constant infusion of 1 g/h for 48 h after a 2 g loading dose, reduces morbidity and mortality in moderately severe cases of acute organophosphorus-pesticide poisoning.
Biochemical and clinical profile after organophosphorus poisoning--a placebo-controlled trial using pralidoxime. [2005.05]
BACKGROUND: Organophosphorus (OP) compounds are the most common suicidal poison in developing countries and mortality continues to be high... CONCLUSIONS: Treatment with P2AM does not make any difference in BuChE reactivation or complications of moderate and severe OP poisoning. We have not been using P2AM for OP poisoning in our medical ICU with good patient outcomes.
Acute renal failure enhances the antidotal activity of pralidoxime towards paraoxon-induced respiratory toxicity. [2009.08.25]
We recently showed in a rat model of dichromate-induced acute renal failure (ARF) that the elimination but not the distribution of pralidoxime was altered resulting in sustained plasma pralidoxime concentrations. The aim of this study was to compare the efficiency of pralidoxime in normal and acute renal failure rats against paraoxon-induced respiratory toxicity...
Bioavailability of diazepam after intramuscular injection of its water-soluble prodrug alone or with atropine-pralidoxime in healthy volunteers. [2009.08]
BACKGROUND AND PURPOSE: The aim of this study was to assess the relative bioavailability of diazepam after administration of diazepam itself or as a water-soluble prodrug, avizafone, in humans. EXPERIMENTAL APPROACH: The study was conducted in an open, randomized, single-dose, three-way, cross-over design...
Clinical Trials Related to Protopam (Pralidoxime)
Study to Know the Efficacy of Higher Doses of Pralidoxime in Patients of Organophpsphorus Poisoning. [Completed]
The purpose of this study is to determine whether high doses of pralidoxime(PAM) are
effective as compare to lower doses of PAM in the management of moderately sever
organophosphorus poisoning patients.
|
