Dinoprostone, as with other potent oxytocic agents, should be used only with strict adherence to recommended dosages. Dinoprostone should be used by medically trained personnel in a hospital which can provide immediate intensive care and acute surgical facilities.
Media Articles Related to Prostin E2 (Dinoprostone Vaginal)
Drug/catheter combo for labor induction could save 2.4 million hours of labor annually, Penn study shows
Source: Nursing / Midwifery News From Medical News Today [2016.12.07]
Labor induction is one of the most common medical procedures in the world, with nearly one-quarter of women who deliver in the U.S. undergoing the procedure each year (totaling roughly 1 million).
Labor induction: No association with autism
Source: Nursing / Midwifery News From Medical News Today [2016.07.25]
Contrary to a previous study, new research from more than 1.3 million births concludes that there is no association between labor induction and autism.
Published Studies Related to Prostin E2 (Dinoprostone Vaginal)
A randomized clinical trial to compare the efficacy of different doses of intravaginal misoprostol with intracervical dinoprostone for cervical ripening and labor induction. [2011.07]
OBJECTIVES: To compare the efficacy of 25 vs. 50 microg of intravaginal misoprostol vs. intracervical dinoprostone for cervical ripening and labor induction... CONCLUSION: Intravaginal misoprostol 50 microg administered 6 hourly appears to be most effective as it has least induction to delivery time, has maximum improvement in Bishop's score, least oxytocin requirement without any increase in complication rate.
Cardiotocographic abnormalities associated with misoprostol and dinoprostone cervical ripening and labor induction. [2011.06]
OBJECTIVE: To characterize the incidence and timing of cardiotocographic (CTG) abnormalities associated with misoprostol and dinoprostone vaginal inserts during labor induction... CONCLUSION: Cardiotocographic abnormalities were less frequent and occurred after longer exposure with MVI 50 than MVI 100 or dinoprostone. Clinical outcomes were similar among the groups. Copyright (c) 2011 Elsevier Ireland Ltd. All rights reserved.
[Comparison of isosorbide dinitrate and dinoprostone for induction of labor in term pregnancy]. [2011.05]
CONCLUSIONS: the isosorbide dinitrate is associated with lower duration of labor compared with dinoprostone. There was no difference in the maternal-fetal outcome by using whatever drug.
Induction of labor and pain: a randomized trial between two vaginal preparations of dinoprostone in nulliparous women with an unfavorable cervix. [2011.05]
OBJECTIVE: To compare pain associated with vaginal dinoprostone pessary vs. gel for induction of labor in women with an unfavorable cervix... CONCLUSIONS: The two induction procedures should be considered equivalent as far as ripening the cervix and initiating labor. In view of this finding, the low Bishop score should be considered an indication to prefer the controlled-release device, since it reduces pain thereby improving the physical and emotional wellbeing of the parturient.
Sustained-release dinoprostone vaginal pessary with concurrent high-dose oxytocin infusion compared to sustained-release dinoprostone vaginal pessary followed 6 h later by high-dose oxytocin infusion for labor induction in women at term with unfavorable cervix: a randomized controlled trial. 
OBJECTIVE: To compare the efficacy and safety of sustained-release dinoprostone vaginal pessary and concurrent high-dose oxytocin infusion with sustained-release dinoprostone vaginal pessary followed 6 h later by high-dose oxytocin infusion for cervical ripening and labor induction... CONCLUSION: Sustained-release dinoprostone followed 6 h later by high-dose oxytocin infusion appears to be safer and more effective than sustained-release dinoprostone with concurrent high-dose oxytocin infusion in achieving cervical ripening and successful vaginal delivery. Copyright (c) 2010 S. Karger AG, Basel.
Clinical Trials Related to Prostin E2 (Dinoprostone Vaginal)
Prostin and Propess in Induction of Labor [Completed]
The purpose of the study was to compare the safety and efficacy of two agents used in
induction of labor Propess (Controlled release dinoprostone, PGE2, pessary) and Prostin E2
(Dinoprostone vaginal Tablet).
Prostaglandin E2 in Migraine Suffers Without Aura. [Completed]
The hypothesis of this study is that Prostaglandin E2 (PGE2) induces headache and dilatation
of brain vessels in migraine patients without aura.
A Trial of Prostaglandin E2 Tablets Versus Foley Catheter for Labor Induction [Recruiting]
A randomized controlled trial comparing labor induction with vaginal PGE2 tablets and foley
catheter for cervical ripening.
Cervical Ripening Before Induction of Labour at Term: a Randomised Comparison of Prostin vs Propess [Completed]
The aim of this study is to compare two different preparation