Prostascint (Capromab Pendetide) - Drug Interactions, Contraindications, Overdosage

DRUG INTERACTIONS

Drug Interactions

The effect of surgical and/or medical androgen ablation on the imaging performance of Indium In 111 ProstaScint^® has not been studied. Preliminary data suggest hormone ablation may increase PSMA expression, with concurrent decrease in tumor expression of PSA.³ The use of ProstaScint^® in this patient population cannot be recommended at this time.

OVERDOSAGE

The maximum amount of Indium In 111 ProstaScint^® (Capromab Pendetide) that can be safely administered has not been determined. In clinical studies, single doses of 10 mg of Indium In 111 ProstaScint^® were administered to 20 patients with prostate cancer; the type and frequency of adverse reactions at this dose were similar to those observed with lower doses. The maximum Indium In 111 dose administered with ProstaScint^®in a clinical study was 6.5 mCi.

CONTRAINDICATIONS

Indium In 111 ProstaScint^® (Capromab Pendetide) should not be used in patients who are hypersensitive to this or any other product of murine origin or to Indium In 111 chloride.