ProSom (estazolam), a triazolobenzodiazepine derivative, is an oral hypnotic agent. Estazolam occurs as a fine, white, odorless powder that is soluble in alcohol and practically insoluble in water. The chemical name for estazolam is 8-chloro-6-phenyl-4H-s-triazolo[4,3-(alpha)] [1,4]benzodiazepine. The empirical formula is C16H11ClN4.
ProSom (estazolam) is indicated for the short-term management of insomnia characterized by difficulty in falling asleep, frequent nocturnal awakenings, and/or early morning awakenings. Both outpatient studies and a sleep laboratory study have shown that ProSom administered at bedtime improved sleep induction and sleep maintenance (see CLINICAL PHARMACOLOGY).
Because insomnia is often transient and intermittent, the prolonged administration of ProSom is generally neither necessary nor recommended. Since insomnia may be a symptom of several other disorders, the possibility that the complaint may be related to a condition for which there is a more specific treatment should be considered.
There is evidence to support the ability of ProSom to enhance the duration and quality of sleep for intervals up to 12 weeks (see CLINICAL PHARMACOLOGY).
Media Articles Related to Prosom (Estazolam)
Insomniacs' Brains May Work Differently
Source: Yahoo Health News [2014.03.01]
FRIDAY, Feb. 28, 2014 (HealthDay News) -- The brains of insomniacs buzz with more activity during the day, preliminary new research suggests, offering possible insight into why people with sleep problems complain that their minds won't shut down a...
Clinical Benefits of Ramelteon for Insomnia Small
Source: Medscape Medical News Headlines [2014.02.28]
Short-term use of the selective melatonin receptor agonist ramelteon (Rozerem) is associated with improvement in some sleep parameters in adults with insomnia but its clinical impact is 'small.'
Reuters Health Information
As few as 3 cognitive behavioral therapy sessions for insomnia can reduce health care utilization and costs
Source: Sleep / Sleep Disorders / Insomnia News From Medical News Today [2014.02.18]
A new study is the first to show decreases in health care utilization and costs following brief treatment with cognitive behavioral therapy for insomnia (CBTI).Results show that sleep improved in 86 percent of insomnia patients who completed at least three sessions of CBTI.
Insomnia Cure Boosts Success of Depression Treatment, Study Finds
Source: MedicineNet Sleep Aids And Stimulants Specialty [2013.11.20]
Title: Insomnia Cure Boosts Success of Depression Treatment, Study Finds
Category: Health News
Created: 11/19/2013 4:36:00 PM
Last Editorial Review: 11/20/2013 12:00:00 AM
Prescription Sleep Aids a Common Choice for American Insomnia
Source: MedicineNet temazepam Specialty [2013.08.29]
Title: Prescription Sleep Aids a Common Choice for American Insomnia
Category: Health News
Created: 8/29/2013 9:35:00 AM
Last Editorial Review: 8/29/2013 12:00:00 AM
Published Studies Related to Prosom (Estazolam)
[Analysis on somnipathy related factors in elderly patients with stroke and comparative study on the efficacy of treatment by traditional Chinese medicine and by estazolam] [2009.03]
OBJECTIVE: To analyze the somnipathy related factors in elderly patients with stroke and to compare effects of traditional Chinese medicine and estazolam on sleep and the followed nervous function... CONCLUSION: The occurrence of somnipathy in stroke patients was closely related with the property and site of lesion, and the neurological deficit degree of patients. Better sleep is surely favorable for recovery of the nervous function, and TCM shows a favorable efficacy on somnipathy.
Comparative bioavailability of two estazolam tablet formulations in Indonesian healthy volunteers. 
AIM: To compare the bioavailability of two estazolam (CAS 29975-16-4) tablet formulations (Estalin 2 mg tablets as test formulation and 2 mg tablets of the originator product as reference formulation)... CONCLUSION: These results indicate that two formulations of estazolam are bioequivalent and, thus, may be prescribed interchangeably.
No effect of itraconazole on the single oral dose pharmacokinetics and pharmacodynamics of estazolam. [2002.06]
To examine the involvement of cytochrome P450 3A4 in the metabolism of estazolam, the effect of itraconazole, a potent inhibitor of this enzyme, on the single oral dose pharmacokinetics and pharmacodynamics of estazolam was studied in a double-blind randomized crossover manner... The current study showed no significant effect of itraconazole on the single oral dose pharmacokinetics and pharmacodynamics of estazolam, suggesting that cytochrome P450 3A4 is not involved in the metabolism of estazolam to a major extent.
Gas chromatographic assay for estazolam in human plasma and results of a bioequivalence study. [1997.04]
This paper describes a new sensitive gas chromatographic method with electron capture detector to assay estazolam in human plasma, which has been developed and validated for pharmacokinetic purposes. The drug and the internal standard (triazolam) were extracted from plasma buffered at pH 9.0 into toluene and analysed on a widebore DB 17 column...
Effects of estazolam and flurazepam on cardiopulmonary function in patients with chronic obstructive pulmonary disease. [1992.03]
Benzodiazepine drugs have been shown to suppress respiratory function in patients with chronic obstructive pulmonary disease (COPD). We designed a placebo-controlled crossover study to compare the effects of a new benzodiazepine, estazolam ('ProSom'), with those of flurazepam ('Dalmane') on cardiopulmonary function in COPD patients...
Clinical Trials Related to Prosom (Estazolam)
Randomised, Double-Blind Study to Investigate the Safety and Efficacy of Brotizolam in Insomnia Outpatients. [Completed]
To investigate the efficacy and safety of Brotizolam in the treatment of patients with
insomnia in comparison with that of Estazolam
A Study to Evaluate Efficacy and Safety of Zolpidem Modified Release Formulation in Insomnia Patients [Recruiting]
The purpose of the study is to investigate the efficacy and safety of zolpidem modified
release (MR) tablet using estazolam (Eurodin) as a comparative drug in patients with primary