Proquin XR (Ciprofloxacin Hydrochloride) - Drug Interactions, Contraindications, Overdosage

DRUG INTERACTIONS

Drug Interactions

Antacids: The interaction of ProQuin XR (administered as a single 1000 mg [2 x 500 mg] dose) and magnesium/aluminum-containing antacids (900 mg aluminum hydroxide and 600 mg magnesium hydroxide administered as a single oral dose) was evaluated in healthy volunteers. When ProQuin XR was given 2 hours after antacids and 6 hours before antacids, the C_max values were similar to those when ProQuin XR was given alone and AUC values were reduced by approximately 10%. When ProQuin XR was given 4 hours before antacids, C_max was reduced by approximately 11% and AUC was reduced by approximately 22%. Thus, to minimize the effect of antacids on the absorption of ciprofloxacin, ProQuin XR should be given either 2 hours after or at least 4 hours before antacids (see PRECAUTIONS, Drug Interactions, and Information for Patients).

OVERDOSAGE

In the event of an acute overdosage, the stomach should be emptied by inducing vomiting or by gastric lavage. The patient should be carefully observed and given supportive treatment. Adequate hydration must be maintained. Only a small amount of ciprofloxacin (<10%) is removed from the body after hemodialysis or peritoneal dialysis. Serious adverse effects were not observed in rats receiving single oral doses of ciprofloxacin as high as 2,000 mg/kg.

CONTRAINDICATIONS

ProQuin XR is contraindicated in persons with a history of hypersensitivity to ciprofloxacin or any member of the quinolone class of antimicrobial agents, or any of the product components.