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Propecia (Finasteride) - Summary

 
 



PROPECIA SUMMARY

What is PROPECIA used for?

PROPECIA (finasteride), a synthetic 4-azasteroid compound, is a specific inhibitor of steroid Type II 5(alpha)-reductase, an intracellular enzyme that converts the androgen testosterone into 5(alpha)-dihydrotestosterone (DHT).

PROPECIA is indicated for the treatment of male pattern hair loss (androgenetic alopecia) in MEN ONLY. Safety and efficacy were demonstrated in men between 18 to 41 years of age with mild to moderate hair loss of the vertex and anterior mid-scalp area (see CLINICAL PHARMACOLOGY, Clinical Studies).

Efficacy in bitemporal recession has not been established.

PROPECIA is not indicated in women (see CLINICAL PHARMACOLOGY, Clinical Studies and CONTRAINDICATIONS).

PROPECIA is not indicated in children (see PRECAUTIONS, Pediatric Use).


See all Propecia indications & dosage >>

NEWS HIGHLIGHTS

Published Studies Related to Propecia (Finasteride)

Change in sexual function in men with lower urinary tract symptoms/benign prostatic hyperplasia associated with long-term treatment with doxazosin, finasteride and combined therapy. [2014]
Inventory during 4 years... CONCLUSIONS: This study significantly extends understanding of the effects of

Long-term effects of doxazosin, finasteride, and combination therapy on quality of life in men with benign prostatic hyperplasia. [2013]
International Prostate Symptom Score [IPSS]-QoL) over 4 years... CONCLUSIONS: QoL of men treated with doxazosin, finasteride, and

Long-term effects of doxazosin, finasteride and combination therapy on quality of life in men with benign prostatic hyperplasia. [2013]
International Prostate Symptom Score-QoL) during 4 years... CONCLUSIONS: The quality of life of men treated with doxazosin, finasteride, and

A randomized phase IIb presurgical study of finasteride vs. low-dose flutamide vs. placebo in men with prostate cancer. Efficacy monitored by karyometry. [2013]
preventive agents in patients with CaP... CONCLUSION: This exploratory study establishes that karyometric monitoring can

Comparison of dutasteride and finasteride for treating benign prostatic hyperplasia: the Enlarged Prostate International Comparator Study (EPICS). [2011.08]
OBJECTIVE: * To assess the efficacy and safety of dutasteride compared with finasteride in treating men with symptomatic benign prostatic hyperplasia (BPH) for 12 months... CONCLUSION: * Dutasteride and finasteride, when administered for 12 months, were similarly effective in reducing prostate volume and improving Q(max) and urinary symptoms associated with BPH in men with an enlarged prostate. (c) 2011 THE AUTHORS. BJU INTERNATIONAL (c) 2011 BJU INTERNATIONAL.

more studies >>

Clinical Trials Related to Propecia (Finasteride)

A Phase III, Randomized, Double-Blind, Placebo-Controlled Trial of Proscar in Men With Initial Negative Prostate Biopsies [Not yet recruiting]
Twenty percent of men with an initial negative prostate biopsy are found to have cancer on a repeat biopsy. finasteride (a 5-ARI) reduces prostate volume and improves the utility of PSA and DRE. thus, six months of finasteride may improve the detection rate of prostate cancer in men with an initial negative biopsy.

Randomized, Double-Blind, Placebo-Controlled Trial of Preoperative Finasteride in Patients Undergoing Transurethral Resection of The Prostate [Not yet recruiting]
Transurethral resection of the prostate (TURP) is a common treatment for benign prostatic hyperplasia (BPH). a common complication of TURP is blood loss. preliminary data suggest that preoperative finasteride, a 5a-reductase inhibitor, may reduce blood loss during TURP. however, no study has examined the effect of preoperative finasteride on clinical outcomes.

A Trial of PROSCAR (Finasteride) Versus Placebo in Men With an Initial Negative Prostate Biopsy [Recruiting]
The purpose of this study is to assess whether six months of daily finasteride (PROSCAR), following an initial negative prostate biopsy, will improve the detection of prostate cancer on repeat biopsy.

144 subjects with an initial negative prostate biopsy will be randomized to receive either finasteride or placebo for 6 months. The subjects will undergo a second prostate biopsy following drug intervention. PSA (prostate specific antigen) measurements, testosterone levels, and quality of life questionnaires will also be assessed during the study. The two groups will then be compared.

Comparison of Finasteride and Tamsulosin for Treatment of Benign Prostatic Hyperplasia (BPH) (MK-0906A-149 AM1) [Not yet recruiting]
This study is designed to compare safety and efficacy of monotherapy finasteride to combination therapy (finasteride and tamsulosin) in Asian men with benign prostatic hyperplasia (BPH) who are at least 50 years of age or older.

On Label, Randomized, Double-Blind, Placebo-Controlled Trial of Preoperative Finasteride in Patients Undergoing Transurethral Resection of the Prostate (TURP) [Active, not recruiting]
Transurethral resection of the prostate (TURP) is a common treatment for benign prostatic hyperplasia (BPH). A common complication of TURP is blood loss. Preliminary data suggest that preoperative Finasteride, a 5 alpha-reductase inhibitor, may reduce blood loss during TURP. However, no study has examined the effect of preoperative Finasteride on clinical outcomes.

The study is a randomized, double-blind, placebo-controlled trial of preoperative Finasteride versus placebo in BPH patients undergoing TURP. Participants will be stratified by prostate volume (30 to 65 grams versus 66 to 100 grams) and randomly assigned to preoperative Finasteride or placebo. The primary end point is incidence of RBCT. Secondary end points are standard units of red blood cells transfused, variables related to perioperative bleeding (incidence of readmission, incidence of return to hospital, length of hospital stay), blood loss, change in serum hemoglobin, change in serum hematocrit, blood loss per gram of resected prostate tissue, operating time, change in AUA-SS, and change in HRQOL.

more trials >>

Reports of Suspected Propecia (Finasteride) Side Effects

Erectile Dysfunction (310)Anxiety (260)Sexual Dysfunction (247)Depression (231)Libido Decreased (228)Cognitive Disorder (167)Ejaculation Failure (124)Ejaculation Disorder (123)Loss of Libido (81)Emotional Distress (71)more >>


PATIENT REVIEWS / RATINGS / COMMENTS

Based on a total of 43 ratings/reviews, Propecia has an overall score of 6.70. The effectiveness score is 7.30 and the side effect score is 7.21. The scores are on ten point scale: 10 - best, 1 - worst. Below are selected reviews: the highest, the median and the lowest rated.
 

Propecia review by 49 year old male patient

  Rating
Overall rating:  
Effectiveness:   Highly Effective
Side effects:   No Side Effects
  
Treatment Info
Condition / reason:   hair loss
Dosage & duration:   standard (dosage frequency: once a day) for the period of 3 years
Other conditions:   none
Other drugs taken:   none
  
Reported Results
Benefits:   Hair regrowth in crown area
Side effects:   there were none
Comments:   One pill taken orally daily

 

Propecia review by 46 year old male patient

  Rating
Overall rating:  
Effectiveness:   Highly Effective
Side effects:   Moderate Side Effects
  
Treatment Info
Condition / reason:   Hairloss
Dosage & duration:   .8mg taken 4 days on, 1 day off for the period of 8-9 years
Other conditions:   None
Other drugs taken:   None
  
Reported Results
Benefits:   With using generic finasteride there's no doubt that further hairloss has been prevented in my case. Before beginning on this, my hairloss was rapidly escalating, both at the front and back, and this ceased and slightly reversed once started, and hasn't progressed since.
Side effects:   Definitely loss of libido, tiredness, some fogginess of thought, loss of muscle tone, occasional testicular pain, lowered blood pressure, increased floaters in vision, some gynecomastia when cycling down (minimised by taking Zinc on those days, but I would say not to discontinue this medication suddenly if taking a break or quitting).
Comments:   Mostly generic Proscar - 5mg tablets cut into six equal pieces - 4 days on and one day off in a continuing cycle.

 

Propecia review by 21 year old male patient

  Rating
Overall rating:  
Effectiveness:   Ineffective
Side effects:   Severe Side Effects
  
Treatment Info
Condition / reason:   Hair Loss
Dosage & duration:   1 pill a day taken once a day for the period of 15 months
Other conditions:   none
Other drugs taken:   none
  
Reported Results
Benefits:   after taking propecia for over a year, starting when i was 20 years of age my hair continued to thin, and i noticed no significant benefits
Side effects:   Low sex drive, before i started taking this drug i was 19 years of age and full of "enthousiasm". Now engaged and 21 years old, my sex drive is very low, my wife and I are very unsatisfied. I am also very tired even during peak hours throughout the day, and its hard to concentrate on mundain tasks
Comments:   one pill once daily

See all Propecia reviews / ratings >>

Page last updated: 2014-11-30

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