Promethazine is a neuroleptic drug and a first-generation antihistamine of the phenothiazine family.
PROMETHAZINE is indicated for the following:
Promethazine hydrochloride tablets are useful for:
Perennial and seasonal allergic rhinitis.
Allergic conjunctivitis due to inhalant allergens and foods.
Mild, uncomplicated allergic skin manifestations of urticaria and angioedema.
Amelioration of allergic reactions to blood or plasma.
Anaphylactic reactions, as adjunctive therapy to epinephrine and other standard measures, after the acute manifestations have been controlled.
Preoperative, postoperative, or obstetric sedation.
Prevention and control of nausea and vomiting associated with certain types of anesthesia and surgery.
Therapy adjunctive to meperidine or other analgesics for control of post-operative pain.
Sedation in both children and adults, as well as relief of apprehension and production of light sleep from which the patient can be easily aroused.
Active and prophylactic treatment of motion sickness.
Antiemetic therapy in postoperative patients.
Published Studies Related to Promethazine
Intravenous promethazine versus lorazepam for the treatment of peripheral vertigo
in the emergency department: A double blind, randomized clinical trial of
efficacy and safety. 
vertigo reduction compared with lorazepam in ED patients... CONCLUSION: Our study demonstrated the evidence that promethazine is superior to
Effects of single therapeutic doses of promethazine, fexofenadine and olopatadine
on psychomotor function and histamine-induced wheal- and flare-responses: a
randomized double-blind, placebo-controlled study in healthy volunteers. 
Since most first-generation antihistamines have undesirable sedative effects on
the central nervous systems (CNS), newer (second-generation) antihistamines have
been developed to improve patients' quality of life. However, there are few
reports that directly compare the antihistaminic efficacy and impairment of
Low-dose adrenaline, promethazine, and hydrocortisone in the prevention of acute adverse reactions to antivenom following snakebite: a randomised, double-blind, placebo-controlled trial. [2011.05]
CONCLUSIONS: Pretreatment with low-dose adrenaline was safe and reduced the risk of acute severe reactions to snake antivenom. This may be of particular importance in countries where adverse reactions to antivenom are common, although the need to improve the quality of available antivenom cannot be overemphasized.
A randomized, placebo-controlled trial of ondansetron, metoclopramide, and promethazine in adults. [2011.03]
OBJECTIVES: The objective of the study was to assess whether ondansetron has superior nausea reduction compared with metoclopramide, promethazine, or saline placebo in emergency department (ED) adults... CONCLUSIONS: Our study shows no evidence that ondansetron is superior to metoclopramide and promethazine in reducing nausea in ED adults. Early study termination may have limited detection of ondansetron's superior nausea reduction over saline. Copyright (c) 2011 Elsevier Inc. All rights reserved.
Promethazine compared with metoclopramide for hyperemesis gravidarum: a randomized controlled trial. [2010.05]
OBJECTIVE: To compare the effects of promethazine with those of metoclopramide for hyperemesis gravidarum... CONCLUSION: Promethazine and metoclopramide have similar therapeutic effects in patients who are hospitalized for hyperemesis gravidarum. The adverse effects profile was better with metoclopramide.
Clinical Trials Related to Promethazine
Study of Promethazine for Treatment of Diabetic Gastroparesis [Recruiting]
Adult diabetic patients (ages 18-65) with gastric emptying scintigraphy-confirmed delayed
gastric emptying will be recruited to participate in the study. Using double-blinded
methodology, study participants will be randomly assigned to one of two treatment arms:
promethazine 12. 5 mg three times daily for 28 days or placebo three times daily for 28 days.
The primary outcome will be the change in gastroparesis symptom severity, as measured by
the Gastroparesis Cardinal Symptom Index (GCSI) at four weeks compared to baseline.
Participants will be seen for a clinic evaluation at weeks 0, 2 and 4, during which symptom
scores, adverse events and treatment compliance will be assessed. It is hypothesized
promethazine treatment will be superior to placebo in improving symptoms of gastroparesis.
Morphine Versus Morphine-promethazine Combination for Acute Low Back Pain Relief in the Adult Emergency Department [Not yet recruiting]
Acute low back pain is a common cause for emergency department visits. Controversy remains
regarding the optimal medication for acute low back pain relief. The investigators
hypothesized that administration of pharmacological anxiolysis in addition to analgesia will
improve pain relief and patient management in the emergency department.
Effect of Hyoscine and Promethazine on Labor Pain [Completed]
It is always considered to shorten the duration of delivery without compromising the mother
and fetus by obstetrics. Hyoscine and Promethazine are used widely in hospital and research
is very limited, with conflicting results regarding the efficacy of these two drugs. So the
investigators decided to compare of effect of hyoscine N-butyl bromide and Promethazine on
length of active phase of the first stage of labor.
Pharmacogenetic Factors and Side Effects of Metoclopramide and Diphenhydramine [Active, not recruiting]
Promethazine vs. Lorazepam for Treatment of Vertigo [Completed]
This study was a prospective, randomized, double-blind, parallel group clinical trial
designed to compare the efficacy of intravenous (IV) promethazine and lorazepam for the
treatment of peripheral vertigo in Emergency Department setting.
Reports of Suspected Promethazine Side Effects
Completed Suicide (42),
Toxicity TO Various Agents (33),
Respiratory Arrest (17),
Cardiac Arrest (17),
Drug Ineffective (9), more >>
Page last updated: 2014-11-30