Each teaspoon (5 mL) of Promethazine HCl and Dextromethorphan Hydrobromide Oral Solution contains 6.25 mg promethazine HCl and 15 mg dextromethorphan hydrobromide. Promethazine HCl is a phenothiazine derivative. Dextromethorphan hydrobromide is a salt of the methyl ether of the dextrorotatory isomer of levorphanol, a narcotic analgesic.
Promethazine HCl and Dextromethorphan Hydrobromide Oral Solution is indicated for the temporary relief of coughs and upper respiratory symptoms associated with allergy or the common cold.
Clinical Trials Related to Promethazine and Dextromethorphan (Promethazine / Dextromethorphan)
Study of Promethazine for Treatment of Diabetic Gastroparesis [Recruiting]
Adult diabetic patients (ages 18-65) with gastric emptying scintigraphy-confirmed delayed
gastric emptying will be recruited to participate in the study. Using double-blinded
methodology, study participants will be randomly assigned to one of two treatment arms:
promethazine 12. 5 mg three times daily for 28 days or placebo three times daily for 28 days.
The primary outcome will be the change in gastroparesis symptom severity, as measured by
the Gastroparesis Cardinal Symptom Index (GCSI) at four weeks compared to baseline.
Participants will be seen for a clinic evaluation at weeks 0, 2 and 4, during which symptom
scores, adverse events and treatment compliance will be assessed. It is hypothesized
promethazine treatment will be superior to placebo in improving symptoms of gastroparesis.
Morphine Versus Morphine-promethazine Combination for Acute Low Back Pain Relief in the Adult Emergency Department [Not yet recruiting]
Acute low back pain is a common cause for emergency department visits. Controversy remains
regarding the optimal medication for acute low back pain relief. The investigators
hypothesized that administration of pharmacological anxiolysis in addition to analgesia will
improve pain relief and patient management in the emergency department.
Effect of Hyoscine and Promethazine on Labor Pain [Completed]
It is always considered to shorten the duration of delivery without compromising the mother
and fetus by obstetrics. Hyoscine and Promethazine are used widely in hospital and research
is very limited, with conflicting results regarding the efficacy of these two drugs. So the
investigators decided to compare of effect of hyoscine N-butyl bromide and Promethazine on
length of active phase of the first stage of labor.
Pharmacogenetic Factors and Side Effects of Metoclopramide and Diphenhydramine [Active, not recruiting]
Promethazine vs. Lorazepam for Treatment of Vertigo [Completed]
This study was a prospective, randomized, double-blind, parallel group clinical trial
designed to compare the efficacy of intravenous (IV) promethazine and lorazepam for the
treatment of peripheral vertigo in Emergency Department setting.
Page last updated: 2008-10-10